Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02545:Vmn2r66'

297774

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r66

Ensembl Gene

ENSMUSG00000094950

Gene Name

vomeronasal 2, receptor 66

Synonyms

F830104D24Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL02545

Quality Score

Status

Chromosome

Chromosomal Location

84643853-84661228 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 84655798 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 406 (M406K)

Ref Sequence

ENSEMBL: ENSMUSP00000122645 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000124773]

AlphaFold

A0A3B2W842

Predicted Effect

possibly damaging
Transcript: ENSMUST00000124773
AA Change: M406K

PolyPhen 2 Score 0.495 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000122645
Gene: ENSMUSG00000094950
AA Change: M406K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	77	463	5e-31	PFAM
Pfam:NCD3G	507	559	6e-21	PFAM
Pfam:7tm_3	589	827	3.8e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930523C07Rik	T	C	1: 159,902,994 (GRCm39)	L88P	probably damaging	Het
Adamtsl4	G	A	3: 95,590,684 (GRCm39)	Q354*	probably null	Het
Aox3	A	C	1: 58,222,645 (GRCm39)	D1146A	probably damaging	Het
Ap2a1	T	A	7: 44,555,850 (GRCm39)	H340L	probably damaging	Het
Ccni	G	T	5: 93,335,636 (GRCm39)	F167L	probably benign	Het
Ctcf	A	G	8: 106,391,013 (GRCm39)	T207A	probably benign	Het
D930020B18Rik	A	G	10: 121,525,838 (GRCm39)	H580R	possibly damaging	Het
Dnaaf6rt	A	G	1: 31,262,177 (GRCm39)	D53G	probably damaging	Het
Dock3	A	T	9: 106,939,271 (GRCm39)	L159Q	probably damaging	Het
Dync1i2	T	C	2: 71,093,095 (GRCm39)	I630T	possibly damaging	Het
Fchsd2	A	G	7: 100,847,715 (GRCm39)	T202A	probably benign	Het
Gdi2	A	G	13: 3,607,009 (GRCm39)	Y214C	probably damaging	Het
Gna14	T	A	19: 16,511,090 (GRCm39)	S46R	probably damaging	Het
Hfm1	A	G	5: 107,043,153 (GRCm39)	I627T	probably damaging	Het
Ighv1-19	G	A	12: 114,672,359 (GRCm39)	A87V	probably damaging	Het
Itch	G	A	2: 155,014,506 (GRCm39)		probably null	Het
Klrb1b	T	C	6: 128,797,272 (GRCm39)	Q72R	possibly damaging	Het
Lrpprc	A	G	17: 85,082,853 (GRCm39)	F144L	probably benign	Het
Lrrc7	A	G	3: 157,891,011 (GRCm39)		probably benign	Het
Ndufa11	T	A	17: 57,028,338 (GRCm39)	F72L	probably damaging	Het
Neu1	T	A	17: 35,150,477 (GRCm39)	V32E	probably benign	Het
Or5k17	T	A	16: 58,746,833 (GRCm39)	I34F	possibly damaging	Het
Osmr	T	C	15: 6,853,060 (GRCm39)	K611E	probably damaging	Het
Pcdh20	A	G	14: 88,706,280 (GRCm39)	V340A	possibly damaging	Het
Plxna2	T	A	1: 194,468,998 (GRCm39)		probably benign	Het
Pou6f1	C	T	15: 100,481,306 (GRCm39)	W210*	probably null	Het
Ppat	A	G	5: 77,063,079 (GRCm39)	Y511H	probably damaging	Het
Psme4	T	G	11: 30,791,586 (GRCm39)	V1147G	possibly damaging	Het
Scap	C	T	9: 110,207,758 (GRCm39)	T489I	probably benign	Het
Sptb	A	G	12: 76,654,754 (GRCm39)		probably null	Het
Tcl1b5	T	A	12: 105,146,296 (GRCm39)		probably benign	Het
Trim54	T	A	5: 31,289,509 (GRCm39)		probably benign	Het
Unc13c	C	T	9: 73,388,357 (GRCm39)	R2143Q	probably damaging	Het
Vmn1r56	A	T	7: 5,199,113 (GRCm39)	V168D	probably benign	Het

Other mutations in Vmn2r66

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00321:Vmn2r66	APN	7	84,656,299 (GRCm39)	missense	probably benign
IGL01562:Vmn2r66	APN	7	84,656,495 (GRCm39)	missense	probably benign	0.03
IGL01689:Vmn2r66	APN	7	84,657,033 (GRCm39)	missense	probably damaging	1.00
IGL02237:Vmn2r66	APN	7	84,643,908 (GRCm39)	missense	probably benign
IGL02415:Vmn2r66	APN	7	84,656,020 (GRCm39)	missense	probably damaging	0.97
IGL02439:Vmn2r66	APN	7	84,654,455 (GRCm39)	splice site	probably benign
IGL02708:Vmn2r66	APN	7	84,655,796 (GRCm39)	missense	probably benign	0.00
IGL02794:Vmn2r66	APN	7	84,644,623 (GRCm39)	missense	probably benign	0.00
IGL02885:Vmn2r66	APN	7	84,644,723 (GRCm39)	missense	probably benign	0.00
IGL02975:Vmn2r66	APN	7	84,656,182 (GRCm39)	missense	probably damaging	0.98
IGL03027:Vmn2r66	APN	7	84,644,777 (GRCm39)	splice site	probably benign
IGL03081:Vmn2r66	APN	7	84,657,138 (GRCm39)	missense	probably benign
PIT4131001:Vmn2r66	UTSW	7	84,644,301 (GRCm39)	missense	probably damaging	1.00
R0098:Vmn2r66	UTSW	7	84,654,965 (GRCm39)	missense	probably damaging	1.00
R0504:Vmn2r66	UTSW	7	84,656,023 (GRCm39)	missense	probably damaging	0.99
R0557:Vmn2r66	UTSW	7	84,643,972 (GRCm39)	missense	probably damaging	1.00
R0617:Vmn2r66	UTSW	7	84,644,484 (GRCm39)	missense	probably benign	0.02
R0883:Vmn2r66	UTSW	7	84,657,070 (GRCm39)	missense	probably benign
R1159:Vmn2r66	UTSW	7	84,644,613 (GRCm39)	missense	probably benign	0.44
R1168:Vmn2r66	UTSW	7	84,656,062 (GRCm39)	missense	possibly damaging	0.46
R1172:Vmn2r66	UTSW	7	84,654,799 (GRCm39)	missense	probably benign	0.04
R1175:Vmn2r66	UTSW	7	84,654,799 (GRCm39)	missense	probably benign	0.04
R1538:Vmn2r66	UTSW	7	84,644,166 (GRCm39)	missense	possibly damaging	0.84
R1658:Vmn2r66	UTSW	7	84,656,955 (GRCm39)	missense	probably benign	0.07
R1937:Vmn2r66	UTSW	7	84,644,344 (GRCm39)	missense	probably damaging	0.99
R1989:Vmn2r66	UTSW	7	84,661,201 (GRCm39)	missense	probably benign	0.01
R2698:Vmn2r66	UTSW	7	84,644,607 (GRCm39)	missense	probably damaging	1.00
R2890:Vmn2r66	UTSW	7	84,661,027 (GRCm39)	splice site	probably null
R3686:Vmn2r66	UTSW	7	84,644,397 (GRCm39)	missense	probably damaging	0.96
R4152:Vmn2r66	UTSW	7	84,654,800 (GRCm39)	missense	probably benign	0.08
R4500:Vmn2r66	UTSW	7	84,657,162 (GRCm39)	missense	probably damaging	1.00
R4618:Vmn2r66	UTSW	7	84,644,296 (GRCm39)	missense	possibly damaging	0.62
R4656:Vmn2r66	UTSW	7	84,661,204 (GRCm39)	missense	possibly damaging	0.87
R4668:Vmn2r66	UTSW	7	84,643,905 (GRCm39)	missense	probably damaging	1.00
R4942:Vmn2r66	UTSW	7	84,656,980 (GRCm39)	missense	probably damaging	1.00
R5163:Vmn2r66	UTSW	7	84,656,017 (GRCm39)	missense	probably benign	0.01
R5223:Vmn2r66	UTSW	7	84,657,093 (GRCm39)	missense	probably benign
R5377:Vmn2r66	UTSW	7	84,656,026 (GRCm39)	missense	probably damaging	0.99
R5512:Vmn2r66	UTSW	7	84,657,149 (GRCm39)	missense	probably damaging	1.00
R5611:Vmn2r66	UTSW	7	84,654,951 (GRCm39)	nonsense	probably null
R5749:Vmn2r66	UTSW	7	84,655,979 (GRCm39)	nonsense	probably null
R6131:Vmn2r66	UTSW	7	84,644,224 (GRCm39)	missense	probably damaging	1.00
R6183:Vmn2r66	UTSW	7	84,644,766 (GRCm39)	missense	possibly damaging	0.81
R6509:Vmn2r66	UTSW	7	84,656,054 (GRCm39)	missense	probably benign	0.12
R6930:Vmn2r66	UTSW	7	84,661,216 (GRCm39)	missense	possibly damaging	0.80
R6992:Vmn2r66	UTSW	7	84,654,436 (GRCm39)	missense	possibly damaging	0.90
R7015:Vmn2r66	UTSW	7	84,644,766 (GRCm39)	missense	possibly damaging	0.81
R7302:Vmn2r66	UTSW	7	84,654,423 (GRCm39)	missense	probably benign	0.00
R7516:Vmn2r66	UTSW	7	84,661,176 (GRCm39)	missense	possibly damaging	0.51
R7763:Vmn2r66	UTSW	7	84,654,909 (GRCm39)	missense	probably benign	0.01
R7814:Vmn2r66	UTSW	7	84,656,472 (GRCm39)	missense	probably benign	0.02
R8077:Vmn2r66	UTSW	7	84,656,093 (GRCm39)	missense	probably benign
R8307:Vmn2r66	UTSW	7	84,656,270 (GRCm39)	missense	probably benign
R8315:Vmn2r66	UTSW	7	84,643,932 (GRCm39)	missense	possibly damaging	0.90
R8490:Vmn2r66	UTSW	7	84,654,794 (GRCm39)	critical splice donor site	probably null
R8511:Vmn2r66	UTSW	7	84,656,026 (GRCm39)	missense	probably damaging	0.99
R8781:Vmn2r66	UTSW	7	84,644,355 (GRCm39)	nonsense	probably null
R8812:Vmn2r66	UTSW	7	84,654,893 (GRCm39)	missense	probably damaging	0.99
R9203:Vmn2r66	UTSW	7	84,654,950 (GRCm39)	missense	probably benign	0.01
R9277:Vmn2r66	UTSW	7	84,661,164 (GRCm39)	missense	probably benign	0.00

Posted On

2015-04-16