Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02547:Psg27'

297855

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg27

Ensembl Gene

ENSMUSG00000070797

Gene Name

pregnancy-specific glycoprotein 27

Synonyms

EG545925, cea15

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02547

Quality Score

Status

Chromosome

Chromosomal Location

18556514-18567305 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 18560628 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 285 (T285A)

Ref Sequence

ENSEMBL: ENSMUSP00000092388 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094794]

AlphaFold

Q497W2

Predicted Effect

probably benign
Transcript: ENSMUST00000094794
AA Change: T285A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000092388
Gene: ENSMUSG00000070797
AA Change: T285A

Domain	Start	End	E-Value	Type
IG	39	140	4.13e-5	SMART
IG	159	260	5.89e-1	SMART
IG	279	380	1.39e-2	SMART
IGc2	396	460	3.62e-10	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5430403G16Rik	C	T	5: 109,678,762		probably null	Het
Akap6	T	A	12: 53,140,696	L1631H	probably damaging	Het
Atf7ip	T	A	6: 136,603,276		probably benign	Het
Atp5o	A	T	16: 91,928,961	Y48N	probably damaging	Het
Birc6	T	G	17: 74,579,645	M656R	probably benign	Het
Camkk1	A	G	11: 73,038,433	R455G	probably benign	Het
Casr	A	T	16: 36,515,674	M91K	probably benign	Het
Ccdc28a	A	T	10: 18,214,146	V124D	possibly damaging	Het
Ccnh	T	C	13: 85,202,504		probably benign	Het
Cdc37	G	T	9: 21,139,966		probably benign	Het
Cdon	A	G	9: 35,478,654	D868G	probably damaging	Het
Cyp4f15	A	G	17: 32,700,255	R351G	probably benign	Het
Dclk3	T	C	9: 111,469,023	I545T	probably damaging	Het
Dock4	A	G	12: 40,737,479	M798V	probably benign	Het
Gas7	A	T	11: 67,665,435	Q200L	probably damaging	Het
Gm15448	T	C	7: 3,821,661	D573G	probably damaging	Het
Gm4758	A	T	16: 36,312,526		probably benign	Het
Gm6614	A	T	6: 141,990,390	L323Q	probably damaging	Het
Ica1	T	C	6: 8,670,691		probably null	Het
Idh3a	T	A	9: 54,592,395	V31D	probably benign	Het
Il3ra	A	T	14: 14,351,970	T247S	probably benign	Het
Itgb7	A	G	15: 102,218,510	C497R	probably damaging	Het
Itm2c	T	C	1: 85,906,461	Y166H	probably damaging	Het
Mphosph8	A	G	14: 56,672,484	D98G	probably damaging	Het
Mstn	A	T	1: 53,064,125	I207F	probably benign	Het
Muc15	A	G	2: 110,731,305	R29G	probably damaging	Het
Neb	T	A	2: 52,188,730	T142S	probably damaging	Het
Nipbl	G	A	15: 8,351,598	T570I	probably benign	Het
Nr5a2	T	A	1: 136,940,927	M196L	probably benign	Het
Nrp1	C	A	8: 128,493,031	F643L	probably benign	Het
Olfr1098	A	G	2: 86,923,028	F168S	probably damaging	Het
Olfr1441	A	T	19: 12,422,311	M1L	probably benign	Het
Olfr600	A	G	7: 103,346,244	F228S	probably damaging	Het
Olfr625-ps1	T	C	7: 103,682,766	I16T	probably benign	Het
Osbpl9	C	T	4: 109,068,483	W446*	probably null	Het
Pced1a	T	C	2: 130,419,707	D342G	possibly damaging	Het
Prkcd	C	A	14: 30,599,469	W555L	probably damaging	Het
Prpf31	T	C	7: 3,630,899	S78P	probably benign	Het
Retreg3	A	T	11: 101,106,378	L92*	probably null	Het
Rmdn1	A	G	4: 19,605,501	K282E	possibly damaging	Het
Sept8	G	T	11: 53,537,265	R302L	probably damaging	Het
Serpina3a	A	G	12: 104,116,543	I192V	probably damaging	Het
Sgce	T	C	6: 4,711,301		probably benign	Het
Spats1	A	T	17: 45,474,817		probably benign	Het
Tcerg1l	C	T	7: 138,248,371		probably null	Het
Ttn	A	G	2: 76,729,386	V21230A	probably damaging	Het
Ubxn11	A	C	4: 134,109,584	D41A	possibly damaging	Het
Vps13c	T	G	9: 67,908,019	I979S	possibly damaging	Het
Zc3h6	T	A	2: 129,015,611	H683Q	probably benign	Het
Zfp518a	G	A	19: 40,914,617	G997R	probably damaging	Het
Zfp629	T	C	7: 127,611,674		probably null	Het

Other mutations in Psg27

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00337:Psg27	APN	7	18561804	missense	probably damaging	1.00
IGL00417:Psg27	APN	7	18561917	missense	probably benign	0.22
IGL01344:Psg27	APN	7	18560417	missense	probably damaging	1.00
IGL01781:Psg27	APN	7	18565064	missense	probably damaging	1.00
IGL02926:Psg27	APN	7	18557129	missense	probably damaging	0.99
IGL03074:Psg27	APN	7	18560529	missense	probably benign	0.02
IGL03237:Psg27	APN	7	18560492	missense	probably benign	0.00
IGL02796:Psg27	UTSW	7	18561950	missense	probably benign	0.08
R0437:Psg27	UTSW	7	18560711	splice site	probably benign
R0604:Psg27	UTSW	7	18557072	missense	probably damaging	0.98
R1163:Psg27	UTSW	7	18565309	missense	probably damaging	0.99
R2072:Psg27	UTSW	7	18560417	missense	probably damaging	1.00
R2072:Psg27	UTSW	7	18565009	missense	probably benign	0.16
R2073:Psg27	UTSW	7	18560417	missense	probably damaging	1.00
R2074:Psg27	UTSW	7	18560417	missense	probably damaging	1.00
R2081:Psg27	UTSW	7	18556958	missense	probably damaging	1.00
R2206:Psg27	UTSW	7	18567111	nonsense	probably null
R2866:Psg27	UTSW	7	18561893	missense	probably benign
R3783:Psg27	UTSW	7	18560354	missense	probably damaging	1.00
R3784:Psg27	UTSW	7	18560354	missense	probably damaging	1.00
R4463:Psg27	UTSW	7	18557085	missense	possibly damaging	0.46
R5312:Psg27	UTSW	7	18557033	missense	probably benign	0.43
R5885:Psg27	UTSW	7	18561786	missense	probably damaging	0.96
R6087:Psg27	UTSW	7	18556944	missense	probably benign	0.05
R7011:Psg27	UTSW	7	18556873	missense	probably benign	0.00
R7198:Psg27	UTSW	7	18561801	missense	probably damaging	1.00
R7381:Psg27	UTSW	7	18567083	missense	probably benign	0.20
R7964:Psg27	UTSW	7	18565199	missense	probably damaging	1.00
R8398:Psg27	UTSW	7	18561912	missense	probably benign	0.29
R8472:Psg27	UTSW	7	18562090	missense	probably benign	0.18
R8818:Psg27	UTSW	7	18560412	missense	probably damaging	1.00
R9345:Psg27	UTSW	7	18565156	missense	probably benign	0.02
X0064:Psg27	UTSW	7	18561795	nonsense	probably null

Posted On

2015-04-16