Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02547:Psg27'

297855

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Psg27

Ensembl Gene

ENSMUSG00000070797

Gene Name

pregnancy-specific beta-1-glycoprotein 27

Synonyms

cea15, EG545925

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02547

Quality Score

Status

Chromosome

Chromosomal Location

18290439-18301230 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 18294553 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 285 (T285A)

Ref Sequence

ENSEMBL: ENSMUSP00000092388 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094794]

AlphaFold

Q497W2

Predicted Effect

probably benign
Transcript: ENSMUST00000094794
AA Change: T285A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000092388
Gene: ENSMUSG00000070797
AA Change: T285A

Domain	Start	End	E-Value	Type
IG	39	140	4.13e-5	SMART
IG	159	260	5.89e-1	SMART
IG	279	380	1.39e-2	SMART
IGc2	396	460	3.62e-10	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap6	T	A	12: 53,187,479 (GRCm39)	L1631H	probably damaging	Het
Atf7ip	T	A	6: 136,580,274 (GRCm39)		probably benign	Het
Atp5po	A	T	16: 91,725,849 (GRCm39)	Y48N	probably damaging	Het
Birc6	T	G	17: 74,886,640 (GRCm39)	M656R	probably benign	Het
Camkk1	A	G	11: 72,929,259 (GRCm39)	R455G	probably benign	Het
Casr	A	T	16: 36,336,036 (GRCm39)	M91K	probably benign	Het
Ccdc28a	A	T	10: 18,089,894 (GRCm39)	V124D	possibly damaging	Het
Ccnh	T	C	13: 85,350,623 (GRCm39)		probably benign	Het
Cdc37	G	T	9: 21,051,262 (GRCm39)		probably benign	Het
Cdon	A	G	9: 35,389,950 (GRCm39)	D868G	probably damaging	Het
Cstdc3	A	T	16: 36,132,888 (GRCm39)		probably benign	Het
Cyp4f15	A	G	17: 32,919,229 (GRCm39)	R351G	probably benign	Het
Dclk3	T	C	9: 111,298,091 (GRCm39)	I545T	probably damaging	Het
Dock4	A	G	12: 40,787,478 (GRCm39)	M798V	probably benign	Het
Gas7	A	T	11: 67,556,261 (GRCm39)	Q200L	probably damaging	Het
Ica1	T	C	6: 8,670,691 (GRCm39)		probably null	Het
Idh3a	T	A	9: 54,499,679 (GRCm39)	V31D	probably benign	Het
Il3ra	A	T	14: 14,351,970 (GRCm38)	T247S	probably benign	Het
Itgb7	A	G	15: 102,126,945 (GRCm39)	C497R	probably damaging	Het
Itm2c	T	C	1: 85,834,182 (GRCm39)	Y166H	probably damaging	Het
Mphosph8	A	G	14: 56,909,941 (GRCm39)	D98G	probably damaging	Het
Mstn	A	T	1: 53,103,284 (GRCm39)	I207F	probably benign	Het
Muc15	A	G	2: 110,561,650 (GRCm39)	R29G	probably damaging	Het
Neb	T	A	2: 52,078,742 (GRCm39)	T142S	probably damaging	Het
Nipbl	G	A	15: 8,381,082 (GRCm39)	T570I	probably benign	Het
Nr5a2	T	A	1: 136,868,665 (GRCm39)	M196L	probably benign	Het
Nrp1	C	A	8: 129,219,512 (GRCm39)	F643L	probably benign	Het
Or52ad1	A	G	7: 102,995,451 (GRCm39)	F228S	probably damaging	Het
Or52z15	T	C	7: 103,331,973 (GRCm39)	I16T	probably benign	Het
Or5a3	A	T	19: 12,399,675 (GRCm39)	M1L	probably benign	Het
Or8h8	A	G	2: 86,753,372 (GRCm39)	F168S	probably damaging	Het
Osbpl9	C	T	4: 108,925,680 (GRCm39)	W446*	probably null	Het
Pced1a	T	C	2: 130,261,627 (GRCm39)	D342G	possibly damaging	Het
Pira13	T	C	7: 3,824,660 (GRCm39)	D573G	probably damaging	Het
Prkcd	C	A	14: 30,321,426 (GRCm39)	W555L	probably damaging	Het
Prpf31	T	C	7: 3,633,898 (GRCm39)	S78P	probably benign	Het
Retreg3	A	T	11: 100,997,204 (GRCm39)	L92*	probably null	Het
Rmdn1	A	G	4: 19,605,501 (GRCm39)	K282E	possibly damaging	Het
Septin8	G	T	11: 53,428,092 (GRCm39)	R302L	probably damaging	Het
Serpina3a	A	G	12: 104,082,802 (GRCm39)	I192V	probably damaging	Het
Sgce	T	C	6: 4,711,301 (GRCm39)		probably benign	Het
Slco1a8	A	T	6: 141,936,116 (GRCm39)	L323Q	probably damaging	Het
Spats1	A	T	17: 45,785,743 (GRCm39)		probably benign	Het
Tcerg1l	C	T	7: 137,850,100 (GRCm39)		probably null	Het
Ttn	A	G	2: 76,559,730 (GRCm39)	V21230A	probably damaging	Het
Ubxn11	A	C	4: 133,836,895 (GRCm39)	D41A	possibly damaging	Het
Vps13c	T	G	9: 67,815,301 (GRCm39)	I979S	possibly damaging	Het
Zc3h6	T	A	2: 128,857,531 (GRCm39)	H683Q	probably benign	Het
Zfp1007	C	T	5: 109,826,628 (GRCm39)		probably null	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het
Zfp629	T	C	7: 127,210,846 (GRCm39)		probably null	Het

Other mutations in Psg27

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00337:Psg27	APN	7	18,295,729 (GRCm39)	missense	probably damaging	1.00
IGL00417:Psg27	APN	7	18,295,842 (GRCm39)	missense	probably benign	0.22
IGL01344:Psg27	APN	7	18,294,342 (GRCm39)	missense	probably damaging	1.00
IGL01781:Psg27	APN	7	18,298,989 (GRCm39)	missense	probably damaging	1.00
IGL02926:Psg27	APN	7	18,291,054 (GRCm39)	missense	probably damaging	0.99
IGL03074:Psg27	APN	7	18,294,454 (GRCm39)	missense	probably benign	0.02
IGL03237:Psg27	APN	7	18,294,417 (GRCm39)	missense	probably benign	0.00
IGL02796:Psg27	UTSW	7	18,295,875 (GRCm39)	missense	probably benign	0.08
R0437:Psg27	UTSW	7	18,294,636 (GRCm39)	splice site	probably benign
R0604:Psg27	UTSW	7	18,290,997 (GRCm39)	missense	probably damaging	0.98
R1163:Psg27	UTSW	7	18,299,234 (GRCm39)	missense	probably damaging	0.99
R2072:Psg27	UTSW	7	18,298,934 (GRCm39)	missense	probably benign	0.16
R2072:Psg27	UTSW	7	18,294,342 (GRCm39)	missense	probably damaging	1.00
R2073:Psg27	UTSW	7	18,294,342 (GRCm39)	missense	probably damaging	1.00
R2074:Psg27	UTSW	7	18,294,342 (GRCm39)	missense	probably damaging	1.00
R2081:Psg27	UTSW	7	18,290,883 (GRCm39)	missense	probably damaging	1.00
R2206:Psg27	UTSW	7	18,301,036 (GRCm39)	nonsense	probably null
R2866:Psg27	UTSW	7	18,295,818 (GRCm39)	missense	probably benign
R3783:Psg27	UTSW	7	18,294,279 (GRCm39)	missense	probably damaging	1.00
R3784:Psg27	UTSW	7	18,294,279 (GRCm39)	missense	probably damaging	1.00
R4463:Psg27	UTSW	7	18,291,010 (GRCm39)	missense	possibly damaging	0.46
R5312:Psg27	UTSW	7	18,290,958 (GRCm39)	missense	probably benign	0.43
R5885:Psg27	UTSW	7	18,295,711 (GRCm39)	missense	probably damaging	0.96
R6087:Psg27	UTSW	7	18,290,869 (GRCm39)	missense	probably benign	0.05
R7011:Psg27	UTSW	7	18,290,798 (GRCm39)	missense	probably benign	0.00
R7198:Psg27	UTSW	7	18,295,726 (GRCm39)	missense	probably damaging	1.00
R7381:Psg27	UTSW	7	18,301,008 (GRCm39)	missense	probably benign	0.20
R7964:Psg27	UTSW	7	18,299,124 (GRCm39)	missense	probably damaging	1.00
R8398:Psg27	UTSW	7	18,295,837 (GRCm39)	missense	probably benign	0.29
R8472:Psg27	UTSW	7	18,296,015 (GRCm39)	missense	probably benign	0.18
R8818:Psg27	UTSW	7	18,294,337 (GRCm39)	missense	probably damaging	1.00
R9345:Psg27	UTSW	7	18,299,081 (GRCm39)	missense	probably benign	0.02
X0064:Psg27	UTSW	7	18,295,720 (GRCm39)	nonsense	probably null

Posted On

2015-04-16