Incidental Mutation 'IGL02547:Olfr1441'
ID 297862
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1441
Ensembl Gene ENSMUSG00000050815
Gene Name olfactory receptor 1441
Synonyms GA_x6K02T2RE5P-2753221-2754177, MOR215-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.121) question?
Stock # IGL02547
Quality Score
Status
Chromosome 19
Chromosomal Location 12417433-12423569 bp(+) (GRCm38)
Type of Mutation start codon destroyed
DNA Base Change (assembly) A to T at 12422311 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 1 (M1L)
Ref Sequence ENSEMBL: ENSMUSP00000150739 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059033] [ENSMUST00000214153] [ENSMUST00000216506]
AlphaFold Q8VFV3
Predicted Effect probably benign
Transcript: ENSMUST00000059033
AA Change: M1L

PolyPhen 2 Score 0.383 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000061963
Gene: ENSMUSG00000050815
AA Change: M1L

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 2.7e-52 PFAM
Pfam:7tm_1 42 313 5e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214153
AA Change: M1L

PolyPhen 2 Score 0.383 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000216506
AA Change: M1L

PolyPhen 2 Score 0.383 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5430403G16Rik C T 5: 109,678,762 probably null Het
Akap6 T A 12: 53,140,696 L1631H probably damaging Het
Atf7ip T A 6: 136,603,276 probably benign Het
Atp5o A T 16: 91,928,961 Y48N probably damaging Het
Birc6 T G 17: 74,579,645 M656R probably benign Het
Camkk1 A G 11: 73,038,433 R455G probably benign Het
Casr A T 16: 36,515,674 M91K probably benign Het
Ccdc28a A T 10: 18,214,146 V124D possibly damaging Het
Ccnh T C 13: 85,202,504 probably benign Het
Cdc37 G T 9: 21,139,966 probably benign Het
Cdon A G 9: 35,478,654 D868G probably damaging Het
Cyp4f15 A G 17: 32,700,255 R351G probably benign Het
Dclk3 T C 9: 111,469,023 I545T probably damaging Het
Dock4 A G 12: 40,737,479 M798V probably benign Het
Gas7 A T 11: 67,665,435 Q200L probably damaging Het
Gm15448 T C 7: 3,821,661 D573G probably damaging Het
Gm4758 A T 16: 36,312,526 probably benign Het
Gm6614 A T 6: 141,990,390 L323Q probably damaging Het
Ica1 T C 6: 8,670,691 probably null Het
Idh3a T A 9: 54,592,395 V31D probably benign Het
Il3ra A T 14: 14,351,970 T247S probably benign Het
Itgb7 A G 15: 102,218,510 C497R probably damaging Het
Itm2c T C 1: 85,906,461 Y166H probably damaging Het
Mphosph8 A G 14: 56,672,484 D98G probably damaging Het
Mstn A T 1: 53,064,125 I207F probably benign Het
Muc15 A G 2: 110,731,305 R29G probably damaging Het
Neb T A 2: 52,188,730 T142S probably damaging Het
Nipbl G A 15: 8,351,598 T570I probably benign Het
Nr5a2 T A 1: 136,940,927 M196L probably benign Het
Nrp1 C A 8: 128,493,031 F643L probably benign Het
Olfr1098 A G 2: 86,923,028 F168S probably damaging Het
Olfr600 A G 7: 103,346,244 F228S probably damaging Het
Olfr625-ps1 T C 7: 103,682,766 I16T probably benign Het
Osbpl9 C T 4: 109,068,483 W446* probably null Het
Pced1a T C 2: 130,419,707 D342G possibly damaging Het
Prkcd C A 14: 30,599,469 W555L probably damaging Het
Prpf31 T C 7: 3,630,899 S78P probably benign Het
Psg27 T C 7: 18,560,628 T285A probably benign Het
Retreg3 A T 11: 101,106,378 L92* probably null Het
Rmdn1 A G 4: 19,605,501 K282E possibly damaging Het
Sept8 G T 11: 53,537,265 R302L probably damaging Het
Serpina3a A G 12: 104,116,543 I192V probably damaging Het
Sgce T C 6: 4,711,301 probably benign Het
Spats1 A T 17: 45,474,817 probably benign Het
Tcerg1l C T 7: 138,248,371 probably null Het
Ttn A G 2: 76,729,386 V21230A probably damaging Het
Ubxn11 A C 4: 134,109,584 D41A possibly damaging Het
Vps13c T G 9: 67,908,019 I979S possibly damaging Het
Zc3h6 T A 2: 129,015,611 H683Q probably benign Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Zfp629 T C 7: 127,611,674 probably null Het
Other mutations in Olfr1441
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01446:Olfr1441 APN 19 12422801 missense possibly damaging 0.91
IGL01653:Olfr1441 APN 19 12422372 missense probably benign
IGL01667:Olfr1441 APN 19 12422756 missense probably benign
IGL01903:Olfr1441 APN 19 12422683 missense probably benign 0.00
IGL02571:Olfr1441 APN 19 12422886 missense possibly damaging 0.79
IGL03310:Olfr1441 APN 19 12422927 missense probably benign
R0539:Olfr1441 UTSW 19 12422809 missense probably damaging 0.97
R0918:Olfr1441 UTSW 19 12423235 missense probably benign 0.25
R1463:Olfr1441 UTSW 19 12422888 missense probably benign 0.41
R4301:Olfr1441 UTSW 19 12422717 missense probably damaging 0.98
R4785:Olfr1441 UTSW 19 12422977 missense probably damaging 0.99
R5513:Olfr1441 UTSW 19 12422683 missense probably benign 0.00
R6188:Olfr1441 UTSW 19 12422610 missense probably benign 0.01
R6411:Olfr1441 UTSW 19 12422986 missense probably benign 0.08
R6625:Olfr1441 UTSW 19 12422841 missense probably damaging 1.00
R6944:Olfr1441 UTSW 19 12423264 missense probably benign
R7425:Olfr1441 UTSW 19 12422840 missense probably damaging 1.00
R7465:Olfr1441 UTSW 19 12423145 missense probably damaging 1.00
R9400:Olfr1441 UTSW 19 12422910 missense possibly damaging 0.62
R9427:Olfr1441 UTSW 19 12422525 missense
Posted On 2015-04-16