Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02547:Or52z15'

297868

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or52z15

Ensembl Gene

ENSMUSG00000073943

Gene Name

olfactory receptor family 52 subfamily Z member 15

Synonyms

MOR31-15P, GA_x6K02T2PBJ9-6416276-6417237, Olfr625

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02547

Quality Score

Status

Chromosome

Chromosomal Location

103331936-103332889 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 103331973 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 16 (I16T)

Ref Sequence

ENSEMBL: ENSMUSP00000095797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098195] [ENSMUST00000190218]

AlphaFold

A0A140T8L4

Predicted Effect

probably benign
Transcript: ENSMUST00000098195
AA Change: I16T

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000095797
Gene: ENSMUSG00000073943
AA Change: I16T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	317	8.1e-110	PFAM
Pfam:7TM_GPCR_Srsx	41	225	3.6e-9	PFAM
Pfam:7tm_1	47	299	1.6e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000190218
AA Change: I6T

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000140044
Gene: ENSMUSG00000073943
AA Change: I6T

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	31	214	7e-8	PFAM
Pfam:7tm_1	37	289	2.8e-26	PFAM
Pfam:7tm_4	136	282	2.7e-28	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap6	T	A	12: 53,187,479 (GRCm39)	L1631H	probably damaging	Het
Atf7ip	T	A	6: 136,580,274 (GRCm39)		probably benign	Het
Atp5po	A	T	16: 91,725,849 (GRCm39)	Y48N	probably damaging	Het
Birc6	T	G	17: 74,886,640 (GRCm39)	M656R	probably benign	Het
Camkk1	A	G	11: 72,929,259 (GRCm39)	R455G	probably benign	Het
Casr	A	T	16: 36,336,036 (GRCm39)	M91K	probably benign	Het
Ccdc28a	A	T	10: 18,089,894 (GRCm39)	V124D	possibly damaging	Het
Ccnh	T	C	13: 85,350,623 (GRCm39)		probably benign	Het
Cdc37	G	T	9: 21,051,262 (GRCm39)		probably benign	Het
Cdon	A	G	9: 35,389,950 (GRCm39)	D868G	probably damaging	Het
Cstdc3	A	T	16: 36,132,888 (GRCm39)		probably benign	Het
Cyp4f15	A	G	17: 32,919,229 (GRCm39)	R351G	probably benign	Het
Dclk3	T	C	9: 111,298,091 (GRCm39)	I545T	probably damaging	Het
Dock4	A	G	12: 40,787,478 (GRCm39)	M798V	probably benign	Het
Gas7	A	T	11: 67,556,261 (GRCm39)	Q200L	probably damaging	Het
Ica1	T	C	6: 8,670,691 (GRCm39)		probably null	Het
Idh3a	T	A	9: 54,499,679 (GRCm39)	V31D	probably benign	Het
Il3ra	A	T	14: 14,351,970 (GRCm38)	T247S	probably benign	Het
Itgb7	A	G	15: 102,126,945 (GRCm39)	C497R	probably damaging	Het
Itm2c	T	C	1: 85,834,182 (GRCm39)	Y166H	probably damaging	Het
Mphosph8	A	G	14: 56,909,941 (GRCm39)	D98G	probably damaging	Het
Mstn	A	T	1: 53,103,284 (GRCm39)	I207F	probably benign	Het
Muc15	A	G	2: 110,561,650 (GRCm39)	R29G	probably damaging	Het
Neb	T	A	2: 52,078,742 (GRCm39)	T142S	probably damaging	Het
Nipbl	G	A	15: 8,381,082 (GRCm39)	T570I	probably benign	Het
Nr5a2	T	A	1: 136,868,665 (GRCm39)	M196L	probably benign	Het
Nrp1	C	A	8: 129,219,512 (GRCm39)	F643L	probably benign	Het
Or52ad1	A	G	7: 102,995,451 (GRCm39)	F228S	probably damaging	Het
Or5a3	A	T	19: 12,399,675 (GRCm39)	M1L	probably benign	Het
Or8h8	A	G	2: 86,753,372 (GRCm39)	F168S	probably damaging	Het
Osbpl9	C	T	4: 108,925,680 (GRCm39)	W446*	probably null	Het
Pced1a	T	C	2: 130,261,627 (GRCm39)	D342G	possibly damaging	Het
Pira13	T	C	7: 3,824,660 (GRCm39)	D573G	probably damaging	Het
Prkcd	C	A	14: 30,321,426 (GRCm39)	W555L	probably damaging	Het
Prpf31	T	C	7: 3,633,898 (GRCm39)	S78P	probably benign	Het
Psg27	T	C	7: 18,294,553 (GRCm39)	T285A	probably benign	Het
Retreg3	A	T	11: 100,997,204 (GRCm39)	L92*	probably null	Het
Rmdn1	A	G	4: 19,605,501 (GRCm39)	K282E	possibly damaging	Het
Septin8	G	T	11: 53,428,092 (GRCm39)	R302L	probably damaging	Het
Serpina3a	A	G	12: 104,082,802 (GRCm39)	I192V	probably damaging	Het
Sgce	T	C	6: 4,711,301 (GRCm39)		probably benign	Het
Slco1a8	A	T	6: 141,936,116 (GRCm39)	L323Q	probably damaging	Het
Spats1	A	T	17: 45,785,743 (GRCm39)		probably benign	Het
Tcerg1l	C	T	7: 137,850,100 (GRCm39)		probably null	Het
Ttn	A	G	2: 76,559,730 (GRCm39)	V21230A	probably damaging	Het
Ubxn11	A	C	4: 133,836,895 (GRCm39)	D41A	possibly damaging	Het
Vps13c	T	G	9: 67,815,301 (GRCm39)	I979S	possibly damaging	Het
Zc3h6	T	A	2: 128,857,531 (GRCm39)	H683Q	probably benign	Het
Zfp1007	C	T	5: 109,826,628 (GRCm39)		probably null	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het
Zfp629	T	C	7: 127,210,846 (GRCm39)		probably null	Het

Other mutations in Or52z15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1160:Or52z15	UTSW	7	103,332,068 (GRCm39)	missense	possibly damaging	0.50
R1508:Or52z15	UTSW	7	103,332,678 (GRCm39)	missense	possibly damaging	0.50
R1766:Or52z15	UTSW	7	103,332,068 (GRCm39)	missense	possibly damaging	0.50
R1901:Or52z15	UTSW	7	103,332,750 (GRCm39)	missense	probably damaging	0.98
R2116:Or52z15	UTSW	7	103,332,519 (GRCm39)	missense	probably damaging	1.00
R4701:Or52z15	UTSW	7	103,332,269 (GRCm39)	missense	probably damaging	1.00
R4995:Or52z15	UTSW	7	103,332,574 (GRCm39)	missense	probably damaging	1.00
R5198:Or52z15	UTSW	7	103,331,936 (GRCm39)	missense	probably benign	0.40
R5750:Or52z15	UTSW	7	103,332,362 (GRCm39)	missense	possibly damaging	0.95
R5776:Or52z15	UTSW	7	103,332,246 (GRCm39)	missense	probably damaging	1.00
R5905:Or52z15	UTSW	7	103,332,781 (GRCm39)	missense	probably damaging	1.00
R5933:Or52z15	UTSW	7	103,332,680 (GRCm39)	missense	probably damaging	1.00
R6488:Or52z15	UTSW	7	103,332,285 (GRCm39)	missense	probably damaging	0.98
R7846:Or52z15	UTSW	7	103,332,407 (GRCm39)	missense	probably benign	0.03
R7878:Or52z15	UTSW	7	103,332,471 (GRCm39)	missense	probably damaging	1.00
R9170:Or52z15	UTSW	7	103,332,404 (GRCm39)	missense	probably benign	0.00
R9347:Or52z15	UTSW	7	103,332,464 (GRCm39)	missense	probably damaging	0.97
R9474:Or52z15	UTSW	7	103,332,477 (GRCm39)	missense	probably damaging	1.00
R9781:Or52z15	UTSW	7	103,332,246 (GRCm39)	missense	probably damaging	1.00
RF040:Or52z15	UTSW	7	103,332,145 (GRCm39)	frame shift	probably null
Z1088:Or52z15	UTSW	7	103,332,393 (GRCm39)	missense	probably benign	0.01
Z1176:Or52z15	UTSW	7	103,332,312 (GRCm39)	missense	probably benign	0.09

Posted On

2015-04-16