Incidental Mutation 'IGL02547:Cdc37'
ID 297903
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdc37
Ensembl Gene ENSMUSG00000019471
Gene Name cell division cycle 37
Synonyms p50Cdc37
Accession Numbers
Essential gene? Probably essential (E-score: 0.947) question?
Stock # IGL02547
Quality Score
Status
Chromosome 9
Chromosomal Location 21050727-21061230 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to T at 21051262 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150265 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019615] [ENSMUST00000215296]
AlphaFold Q61081
Predicted Effect probably benign
Transcript: ENSMUST00000019615
SMART Domains Protein: ENSMUSP00000019615
Gene: ENSMUSG00000019471

DomainStartEndE-ValueType
CDC37_N 1 128 1.07e-69 SMART
CDC37_M 121 283 4.37e-84 SMART
CDC37_C 287 379 1.25e-43 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000215296
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215866
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 T A 12: 53,187,479 (GRCm39) L1631H probably damaging Het
Atf7ip T A 6: 136,580,274 (GRCm39) probably benign Het
Atp5po A T 16: 91,725,849 (GRCm39) Y48N probably damaging Het
Birc6 T G 17: 74,886,640 (GRCm39) M656R probably benign Het
Camkk1 A G 11: 72,929,259 (GRCm39) R455G probably benign Het
Casr A T 16: 36,336,036 (GRCm39) M91K probably benign Het
Ccdc28a A T 10: 18,089,894 (GRCm39) V124D possibly damaging Het
Ccnh T C 13: 85,350,623 (GRCm39) probably benign Het
Cdon A G 9: 35,389,950 (GRCm39) D868G probably damaging Het
Cstdc3 A T 16: 36,132,888 (GRCm39) probably benign Het
Cyp4f15 A G 17: 32,919,229 (GRCm39) R351G probably benign Het
Dclk3 T C 9: 111,298,091 (GRCm39) I545T probably damaging Het
Dock4 A G 12: 40,787,478 (GRCm39) M798V probably benign Het
Gas7 A T 11: 67,556,261 (GRCm39) Q200L probably damaging Het
Ica1 T C 6: 8,670,691 (GRCm39) probably null Het
Idh3a T A 9: 54,499,679 (GRCm39) V31D probably benign Het
Il3ra A T 14: 14,351,970 (GRCm38) T247S probably benign Het
Itgb7 A G 15: 102,126,945 (GRCm39) C497R probably damaging Het
Itm2c T C 1: 85,834,182 (GRCm39) Y166H probably damaging Het
Mphosph8 A G 14: 56,909,941 (GRCm39) D98G probably damaging Het
Mstn A T 1: 53,103,284 (GRCm39) I207F probably benign Het
Muc15 A G 2: 110,561,650 (GRCm39) R29G probably damaging Het
Neb T A 2: 52,078,742 (GRCm39) T142S probably damaging Het
Nipbl G A 15: 8,381,082 (GRCm39) T570I probably benign Het
Nr5a2 T A 1: 136,868,665 (GRCm39) M196L probably benign Het
Nrp1 C A 8: 129,219,512 (GRCm39) F643L probably benign Het
Or52ad1 A G 7: 102,995,451 (GRCm39) F228S probably damaging Het
Or52z15 T C 7: 103,331,973 (GRCm39) I16T probably benign Het
Or5a3 A T 19: 12,399,675 (GRCm39) M1L probably benign Het
Or8h8 A G 2: 86,753,372 (GRCm39) F168S probably damaging Het
Osbpl9 C T 4: 108,925,680 (GRCm39) W446* probably null Het
Pced1a T C 2: 130,261,627 (GRCm39) D342G possibly damaging Het
Pira13 T C 7: 3,824,660 (GRCm39) D573G probably damaging Het
Prkcd C A 14: 30,321,426 (GRCm39) W555L probably damaging Het
Prpf31 T C 7: 3,633,898 (GRCm39) S78P probably benign Het
Psg27 T C 7: 18,294,553 (GRCm39) T285A probably benign Het
Retreg3 A T 11: 100,997,204 (GRCm39) L92* probably null Het
Rmdn1 A G 4: 19,605,501 (GRCm39) K282E possibly damaging Het
Septin8 G T 11: 53,428,092 (GRCm39) R302L probably damaging Het
Serpina3a A G 12: 104,082,802 (GRCm39) I192V probably damaging Het
Sgce T C 6: 4,711,301 (GRCm39) probably benign Het
Slco1a8 A T 6: 141,936,116 (GRCm39) L323Q probably damaging Het
Spats1 A T 17: 45,785,743 (GRCm39) probably benign Het
Tcerg1l C T 7: 137,850,100 (GRCm39) probably null Het
Ttn A G 2: 76,559,730 (GRCm39) V21230A probably damaging Het
Ubxn11 A C 4: 133,836,895 (GRCm39) D41A possibly damaging Het
Vps13c T G 9: 67,815,301 (GRCm39) I979S possibly damaging Het
Zc3h6 T A 2: 128,857,531 (GRCm39) H683Q probably benign Het
Zfp1007 C T 5: 109,826,628 (GRCm39) probably null Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Zfp629 T C 7: 127,210,846 (GRCm39) probably null Het
Other mutations in Cdc37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01943:Cdc37 APN 9 21,054,409 (GRCm39) missense probably benign 0.00
IGL02448:Cdc37 APN 9 21,051,147 (GRCm39) missense possibly damaging 0.55
R0137:Cdc37 UTSW 9 21,053,426 (GRCm39) missense possibly damaging 0.74
R0195:Cdc37 UTSW 9 21,053,576 (GRCm39) missense probably benign 0.01
R0523:Cdc37 UTSW 9 21,054,292 (GRCm39) missense probably damaging 1.00
R0611:Cdc37 UTSW 9 21,053,537 (GRCm39) missense probably damaging 1.00
R0629:Cdc37 UTSW 9 21,052,064 (GRCm39) missense possibly damaging 0.72
R0755:Cdc37 UTSW 9 21,051,160 (GRCm39) missense probably damaging 1.00
R1512:Cdc37 UTSW 9 21,053,712 (GRCm39) splice site probably benign
R2127:Cdc37 UTSW 9 21,061,143 (GRCm39) missense probably damaging 1.00
R2238:Cdc37 UTSW 9 21,053,829 (GRCm39) nonsense probably null
R2239:Cdc37 UTSW 9 21,053,829 (GRCm39) nonsense probably null
R3031:Cdc37 UTSW 9 21,054,487 (GRCm39) missense possibly damaging 0.88
R5068:Cdc37 UTSW 9 21,061,099 (GRCm39) missense probably damaging 0.98
R5169:Cdc37 UTSW 9 21,052,413 (GRCm39) missense probably benign 0.00
R5308:Cdc37 UTSW 9 21,052,060 (GRCm39) missense probably benign 0.00
R5333:Cdc37 UTSW 9 21,054,457 (GRCm39) missense possibly damaging 0.69
R5595:Cdc37 UTSW 9 21,054,509 (GRCm39) missense probably damaging 1.00
R7040:Cdc37 UTSW 9 21,053,519 (GRCm39) missense probably damaging 1.00
R7819:Cdc37 UTSW 9 21,052,260 (GRCm39) missense probably damaging 0.97
R8066:Cdc37 UTSW 9 21,054,437 (GRCm39) missense probably benign 0.01
R8500:Cdc37 UTSW 9 21,052,097 (GRCm39) missense probably damaging 0.99
Posted On 2015-04-16