Incidental Mutation 'IGL02548:Cyp2c29'
ID297924
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2c29
Ensembl Gene ENSMUSG00000003053
Gene Namecytochrome P450, family 2, subfamily c, polypeptide 29
SynonymsAh-2, Cyp2c, P450-2C, Ahh-1, AHOHase, AHOH
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.106) question?
Stock #IGL02548
Quality Score
Status
Chromosome19
Chromosomal Location39269405-39330713 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 39290847 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Aspartic acid at position 96 (G96D)
Ref Sequence ENSEMBL: ENSMUSP00000003137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003137] [ENSMUST00000176624] [ENSMUST00000177087]
Predicted Effect possibly damaging
Transcript: ENSMUST00000003137
AA Change: G96D

PolyPhen 2 Score 0.657 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000003137
Gene: ENSMUSG00000003053
AA Change: G96D

DomainStartEndE-ValueType
low complexity region 7 19 N/A INTRINSIC
Pfam:p450 30 487 5.4e-165 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000176624
AA Change: G57D

PolyPhen 2 Score 0.598 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000135863
Gene: ENSMUSG00000003053
AA Change: G57D

DomainStartEndE-ValueType
Pfam:p450 12 448 2.7e-156 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000177087
AA Change: G96D

PolyPhen 2 Score 0.594 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000135839
Gene: ENSMUSG00000003053
AA Change: G96D

DomainStartEndE-ValueType
low complexity region 7 19 N/A INTRINSIC
Pfam:p450 30 118 8.4e-22 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 G A 7: 46,005,262 A545V probably damaging Het
Adam29 A T 8: 55,872,867 L184* probably null Het
Ap1g1 C T 8: 109,849,622 A432V probably damaging Het
Atrn C T 2: 130,972,282 T716I probably damaging Het
B020004J07Rik T A 4: 101,835,573 Y410F probably damaging Het
Bahd1 C A 2: 118,917,045 Q382K possibly damaging Het
Barhl2 A G 5: 106,455,525 V256A probably benign Het
Camta2 A G 11: 70,670,685 F1113L probably damaging Het
Cdh23 G T 10: 60,650,122 T38K probably benign Het
Cmtm3 T C 8: 104,344,805 L111P probably damaging Het
Col27a1 T C 4: 63,318,255 probably benign Het
Flt1 C A 5: 147,639,248 R650L probably benign Het
Fpr1 T A 17: 17,876,653 E358V probably benign Het
Ggnbp2 A T 11: 84,862,286 N42K possibly damaging Het
Gldc T C 19: 30,099,899 T958A probably benign Het
Gm3573 A G 14: 42,187,495 probably null Het
Hspbp1 T C 7: 4,681,841 probably benign Het
Jhy G T 9: 40,917,175 Y478* probably null Het
Kiz A G 2: 146,870,770 E118G probably damaging Het
Klhdc1 A G 12: 69,253,718 Y144C probably benign Het
Lamc3 A T 2: 31,920,662 Y848F probably benign Het
Mixl1 T C 1: 180,694,704 E204G probably benign Het
Muc2 T A 7: 141,751,857 C202S probably damaging Het
Nfatc1 T C 18: 80,697,898 S282G probably damaging Het
Olfr1465 T C 19: 13,313,938 M116V probably damaging Het
Olfr175-ps1 C A 16: 58,824,328 C127F probably benign Het
Olfr531 T A 7: 140,400,662 Y128F probably damaging Het
Orc2 A T 1: 58,466,122 probably benign Het
Pcdhb10 T C 18: 37,412,690 I273T probably benign Het
Pdzph1 G A 17: 58,973,391 T632I probably benign Het
Phf1 A G 17: 26,935,626 Y225C probably damaging Het
Prcp T C 7: 92,901,174 F60L probably damaging Het
Psg21 C T 7: 18,655,036 V44I possibly damaging Het
Ptgdr C T 14: 44,858,614 V214M probably damaging Het
Pth1r G A 9: 110,727,680 R181W probably damaging Het
Ralgapb A G 2: 158,444,665 I343M probably damaging Het
Retreg1 C T 15: 25,895,118 Q128* probably null Het
Rrbp1 T C 2: 143,949,759 probably benign Het
Skint5 T A 4: 113,731,076 M726L unknown Het
Slc6a18 T C 13: 73,669,995 Y301C probably damaging Het
Slc8a3 G A 12: 81,204,156 probably benign Het
Tacr3 C A 3: 134,829,471 Q67K probably damaging Het
Tfrc A T 16: 32,624,822 K534* probably null Het
Timp3 T A 10: 86,338,451 M67K probably benign Het
Tmem120a C T 5: 135,736,774 E179K probably damaging Het
Tomm40l G A 1: 171,221,647 probably benign Het
Tubal3 A G 13: 3,930,554 R89G probably benign Het
Wdr35 A T 12: 9,024,297 N976I probably benign Het
Zfp292 T C 4: 34,805,416 T2543A probably damaging Het
Zfp976 T A 7: 42,612,529 H628L unknown Het
Zmynd8 A G 2: 165,833,405 V301A probably damaging Het
Other mutations in Cyp2c29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00420:Cyp2c29 APN 19 39321699 splice site probably benign
IGL00482:Cyp2c29 APN 19 39325023 missense probably damaging 0.97
IGL00694:Cyp2c29 APN 19 39321635 missense possibly damaging 0.64
IGL00836:Cyp2c29 APN 19 39324990 missense probably damaging 0.98
IGL00858:Cyp2c29 APN 19 39307656 missense probably damaging 1.00
IGL01350:Cyp2c29 APN 19 39330327 missense probably damaging 1.00
IGL01455:Cyp2c29 APN 19 39329117 missense possibly damaging 0.89
IGL01718:Cyp2c29 APN 19 39330260 missense possibly damaging 0.48
IGL01977:Cyp2c29 APN 19 39290897 splice site probably benign
IGL01991:Cyp2c29 APN 19 39330315 missense probably damaging 1.00
IGL02097:Cyp2c29 APN 19 39307620 missense probably damaging 1.00
IGL02267:Cyp2c29 APN 19 39330422 missense probably benign 0.19
IGL02451:Cyp2c29 APN 19 39290847 missense possibly damaging 0.66
IGL02452:Cyp2c29 APN 19 39290847 missense possibly damaging 0.66
IGL02549:Cyp2c29 APN 19 39309785 missense possibly damaging 0.48
IGL02938:Cyp2c29 APN 19 39287123 missense probably damaging 0.99
IGL03252:Cyp2c29 APN 19 39287175 missense probably damaging 1.00
IGL03367:Cyp2c29 APN 19 39329215 missense probably damaging 0.97
H8562:Cyp2c29 UTSW 19 39309662 missense probably damaging 1.00
IGL03052:Cyp2c29 UTSW 19 39287218 missense possibly damaging 0.90
R0415:Cyp2c29 UTSW 19 39329095 splice site probably benign
R0504:Cyp2c29 UTSW 19 39309780 missense probably benign 0.29
R0690:Cyp2c29 UTSW 19 39309726 missense probably benign 0.00
R1531:Cyp2c29 UTSW 19 39324968 missense probably damaging 1.00
R1730:Cyp2c29 UTSW 19 39324945 missense possibly damaging 0.79
R1981:Cyp2c29 UTSW 19 39307772 splice site probably null
R2113:Cyp2c29 UTSW 19 39330264 missense probably damaging 1.00
R2220:Cyp2c29 UTSW 19 39287232 missense probably benign 0.09
R3873:Cyp2c29 UTSW 19 39329144 missense probably damaging 0.99
R4424:Cyp2c29 UTSW 19 39287176 missense probably damaging 0.98
R4451:Cyp2c29 UTSW 19 39290826 missense probably damaging 0.99
R4803:Cyp2c29 UTSW 19 39324995 missense probably benign 0.01
R5288:Cyp2c29 UTSW 19 39330372 missense probably damaging 0.96
R5474:Cyp2c29 UTSW 19 39324992 missense probably damaging 1.00
R5475:Cyp2c29 UTSW 19 39330287 missense possibly damaging 0.91
R5893:Cyp2c29 UTSW 19 39330389 missense possibly damaging 0.93
R5894:Cyp2c29 UTSW 19 39330389 missense possibly damaging 0.93
R6000:Cyp2c29 UTSW 19 39307606 critical splice acceptor site probably null
R6144:Cyp2c29 UTSW 19 39321609 missense possibly damaging 0.96
R6296:Cyp2c29 UTSW 19 39330261 missense possibly damaging 0.64
R6365:Cyp2c29 UTSW 19 39307754 missense probably damaging 1.00
R6449:Cyp2c29 UTSW 19 39290867 missense probably benign 0.05
R6464:Cyp2c29 UTSW 19 39329225 missense probably damaging 0.96
R6919:Cyp2c29 UTSW 19 39291141 missense probably benign 0.26
R6978:Cyp2c29 UTSW 19 39321663 missense probably damaging 1.00
R7038:Cyp2c29 UTSW 19 39287127 missense probably benign 0.01
R7040:Cyp2c29 UTSW 19 39330337 missense possibly damaging 0.95
R7391:Cyp2c29 UTSW 19 39307767 missense probably null 0.98
X0024:Cyp2c29 UTSW 19 39321599 missense probably benign 0.01
Z1176:Cyp2c29 UTSW 19 39324997 missense probably benign 0.08
Posted On2015-04-16