Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02550:Vmn2r95'

297997

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r95

Ensembl Gene

ENSMUSG00000091631

Gene Name

vomeronasal 2, receptor 95

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL02550

Quality Score

Status

Chromosome

Chromosomal Location

18424078-18460905 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 18451732 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Asparagine at position 577 (I577N)

Ref Sequence

ENSEMBL: ENSMUSP00000156383 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166327] [ENSMUST00000232090] [ENSMUST00000232464]

AlphaFold

A0A338P6T0

Predicted Effect

probably benign
Transcript: ENSMUST00000166327

SMART Domains

Protein: ENSMUSP00000126106
Gene: ENSMUSG00000091631

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	462	1.8e-35	PFAM
Pfam:NCD3G	509	562	3.2e-20	PFAM
Pfam:7tm_3	594	830	3.2e-51	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000232090
AA Change: I649N

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

Predicted Effect

probably damaging
Transcript: ENSMUST00000232464
AA Change: I577N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010109I03Rik	T	G	15: 74,880,755	H24P	probably damaging	Het
Acadl	A	G	1: 66,845,166		probably null	Het
Acer3	G	A	7: 98,223,978	T171I	probably benign	Het
Acsm2	C	T	7: 119,573,284	P117S	probably damaging	Het
Anxa2	A	G	9: 69,467,306	S22G	probably benign	Het
Arrb2	T	C	11: 70,436,870	I120T	probably damaging	Het
Atp11a	G	T	8: 12,816,997	K141N	possibly damaging	Het
Casd1	T	C	6: 4,642,009	V762A	probably benign	Het
Ccdc61	A	T	7: 18,893,302	S48T	probably benign	Het
Cntn2	T	C	1: 132,529,063	M82V	probably null	Het
Cobll1	A	G	2: 65,107,863	S359P	probably damaging	Het
Ctnnbl1	C	A	2: 157,884,135	D465E	probably benign	Het
Def6	A	T	17: 28,228,261	E622V	probably benign	Het
Dmgdh	T	C	13: 93,717,575	Y678H	probably damaging	Het
Dock9	A	T	14: 121,698,312	M1K	probably null	Het
Esyt1	T	C	10: 128,522,093	K216E	probably damaging	Het
Fhod3	A	G	18: 25,022,960	D545G	probably benign	Het
Galnt12	A	T	4: 47,104,126	D128V	possibly damaging	Het
Gm1110	C	T	9: 26,881,834	V549I	probably benign	Het
Gm1966	A	T	7: 106,601,639		noncoding transcript	Het
Gm7361	A	G	5: 26,261,122	I161V	possibly damaging	Het
Gsn	T	C	2: 35,282,607		probably benign	Het
Il16	T	A	7: 83,674,496	Q282L	possibly damaging	Het
Il3ra	A	G	14: 14,348,055	D67G	probably benign	Het
Insrr	T	C	3: 87,804,498	L515P	probably damaging	Het
Jhy	A	G	9: 40,917,170	F480S	probably benign	Het
Klc4	C	A	17: 46,636,910		probably null	Het
Klhl12	G	T	1: 134,467,705	C135F	possibly damaging	Het
Mboat7	G	T	7: 3,683,906		probably null	Het
Myo1f	A	G	17: 33,580,150		probably benign	Het
Myo1f	G	A	17: 33,588,142	D522N	probably damaging	Het
Nbea	C	A	3: 56,019,414	M789I	probably damaging	Het
Ncapd2	T	C	6: 125,177,447	D602G	probably benign	Het
Ncaph2	A	T	15: 89,369,861	K344*	probably null	Het
Nek2	A	G	1: 191,822,259	Y70C	probably damaging	Het
Olfr1277	T	A	2: 111,270,004	D121V	probably damaging	Het
Olfr1281	T	C	2: 111,328,500	L27P	probably damaging	Het
Olfr31	T	C	14: 14,328,423	L104P	possibly damaging	Het
Olfr857	C	A	9: 19,713,047	F73L	possibly damaging	Het
Olfr955	T	A	9: 39,470,546	Y60F	probably benign	Het
Olfr992	G	A	2: 85,399,822	A237V	probably damaging	Het
Plcb3	T	A	19: 6,960,176	K625*	probably null	Het
Plrg1	T	C	3: 83,061,123		probably null	Het
Ptpn12	A	G	5: 20,998,139	V547A	probably benign	Het
Ralgapb	A	G	2: 158,448,411	D748G	probably damaging	Het
Rcbtb2	A	G	14: 73,162,019	E41G	probably damaging	Het
Rela	G	T	19: 5,641,506	R236L	possibly damaging	Het
Rps6kc1	A	G	1: 190,871,862	S188P	probably damaging	Het
Sipa1l1	A	T	12: 82,440,949	K1666*	probably null	Het
Slco1a1	C	T	6: 141,943,465	M40I	probably benign	Het
Smarca4	C	A	9: 21,686,122	P1391Q	probably benign	Het
Stra6	A	G	9: 58,150,083	N392S	possibly damaging	Het
Syt4	A	G	18: 31,444,193	I36T	probably damaging	Het
Tgfbr2	A	T	9: 116,110,129	M235K	probably benign	Het
Tmem87a	T	A	2: 120,374,485		probably null	Het
Tmf1	T	C	6: 97,158,561	D918G	probably benign	Het
Tnfaip2	A	G	12: 111,446,101	Y312C	probably damaging	Het
Usp47	C	T	7: 112,104,354	R1178C	probably damaging	Het
Vps13b	T	C	15: 35,572,096	V953A	probably benign	Het
Wasl	A	G	6: 24,633,884	F127S	probably damaging	Het
Wdr1	C	T	5: 38,540,863	V192I	probably damaging	Het
Wnt9a	C	T	11: 59,330,918	T214I	probably damaging	Het
Xpo5	A	G	17: 46,229,329	D693G	probably benign	Het
Zan	A	G	5: 137,387,039	L5044P	unknown	Het
Zhx3	T	C	2: 160,781,296	N317S	probably damaging	Het

Other mutations in Vmn2r95

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01024:Vmn2r95	APN	17	18452328	utr 3 prime	probably benign
IGL01479:Vmn2r95	APN	17	18443862	missense	probably damaging	1.00
IGL01890:Vmn2r95	APN	17	18451475	missense	probably damaging	1.00
IGL01986:Vmn2r95	APN	17	18440211	missense	probably benign	0.06
IGL02113:Vmn2r95	APN	17	18439907	missense	possibly damaging	0.47
IGL02154:Vmn2r95	APN	17	18451986	missense	probably benign	0.16
IGL02190:Vmn2r95	APN	17	18451776	missense	probably benign	0.00
IGL02412:Vmn2r95	APN	17	18439956	missense	probably damaging	1.00
IGL02679:Vmn2r95	APN	17	18443854	missense	probably damaging	1.00
IGL02691:Vmn2r95	APN	17	18451858	missense	probably benign	0.07
IGL02990:Vmn2r95	APN	17	18452036	nonsense	probably null
IGL03032:Vmn2r95	APN	17	18452313	missense	probably benign	0.00
R0416:Vmn2r95	UTSW	17	18441402	missense	probably damaging	1.00
R0448:Vmn2r95	UTSW	17	18451743	missense	possibly damaging	0.92
R0514:Vmn2r95	UTSW	17	18451582	missense	probably benign
R0519:Vmn2r95	UTSW	17	18439503	missense	probably damaging	1.00
R0539:Vmn2r95	UTSW	17	18452100	missense	probably damaging	1.00
R1501:Vmn2r95	UTSW	17	18439856	missense	probably damaging	0.99
R1598:Vmn2r95	UTSW	17	18452313	missense	probably benign	0.03
R1613:Vmn2r95	UTSW	17	18440639	splice site	probably benign
R1861:Vmn2r95	UTSW	17	18452268	missense	probably damaging	1.00
R1921:Vmn2r95	UTSW	17	18424313	missense	probably benign	0.11
R1986:Vmn2r95	UTSW	17	18451543	missense	probably benign
R2031:Vmn2r95	UTSW	17	18439455	missense	possibly damaging	0.94
R2040:Vmn2r95	UTSW	17	18441299	missense	probably damaging	1.00
R3608:Vmn2r95	UTSW	17	18439973	missense	possibly damaging	0.47
R3727:Vmn2r95	UTSW	17	18441482	nonsense	probably null
R3953:Vmn2r95	UTSW	17	18440096	missense	possibly damaging	0.79
R3955:Vmn2r95	UTSW	17	18440096	missense	possibly damaging	0.79
R3957:Vmn2r95	UTSW	17	18440096	missense	possibly damaging	0.79
R4474:Vmn2r95	UTSW	17	18452245	missense	probably damaging	1.00
R4672:Vmn2r95	UTSW	17	18452151	missense	probably damaging	1.00
R4850:Vmn2r95	UTSW	17	18451653	missense	probably damaging	1.00
R5054:Vmn2r95	UTSW	17	18451446	missense	possibly damaging	0.63
R5178:Vmn2r95	UTSW	17	18440075	missense	probably benign	0.01
R5980:Vmn2r95	UTSW	17	18441362	missense	probably benign
R6183:Vmn2r95	UTSW	17	18443930	missense	probably damaging	0.99
R6276:Vmn2r95	UTSW	17	18451470	missense	possibly damaging	0.96
R6651:Vmn2r95	UTSW	17	18440360	missense	probably damaging	1.00
R6682:Vmn2r95	UTSW	17	18440227	missense	probably damaging	1.00
R6797:Vmn2r95	UTSW	17	18452289	utr 3 prime	probably benign
R6799:Vmn2r95	UTSW	17	18439293	missense	probably damaging	1.00
R6849:Vmn2r95	UTSW	17	18443919	missense	probably damaging	1.00
R6849:Vmn2r95	UTSW	17	18443920	missense	probably damaging	1.00
R6982:Vmn2r95	UTSW	17	18452061	missense	probably damaging	1.00
R7203:Vmn2r95	UTSW	17	18441315	missense	probably benign	0.01
R7226:Vmn2r95	UTSW	17	18451983	missense	possibly damaging	0.90
R7240:Vmn2r95	UTSW	17	18451963	missense	probably benign	0.15
R7383:Vmn2r95	UTSW	17	18440472	missense	probably benign	0.06
R7614:Vmn2r95	UTSW	17	18440090	missense	probably benign
R7755:Vmn2r95	UTSW	17	18424105	start codon destroyed	probably null	0.99
R7942:Vmn2r95	UTSW	17	18440267	missense	possibly damaging	0.74
R8355:Vmn2r95	UTSW	17	18440090	missense	probably benign
R8455:Vmn2r95	UTSW	17	18440090	missense	probably benign
R8478:Vmn2r95	UTSW	17	18452282	missense	probably damaging	1.00
R8547:Vmn2r95	UTSW	17	18443899	missense	probably damaging	1.00
R8752:Vmn2r95	UTSW	17	18441476	missense	probably damaging	0.98
R8788:Vmn2r95	UTSW	17	18451528	missense	probably benign	0.09
R8852:Vmn2r95	UTSW	17	18443851	missense	possibly damaging	0.95
R9098:Vmn2r95	UTSW	17	18439905	missense	possibly damaging	0.88
R9202:Vmn2r95	UTSW	17	18424132	missense	probably benign	0.00
R9244:Vmn2r95	UTSW	17	18451927	missense	possibly damaging	0.91
R9546:Vmn2r95	UTSW	17	18441459	missense	probably benign	0.01
R9665:Vmn2r95	UTSW	17	18440345	missense	probably damaging	0.99
Z1088:Vmn2r95	UTSW	17	18440401	missense	probably benign	0.01

Posted On

2015-04-16