Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02560:Ighg2c'

298182

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ighg2c

Ensembl Gene

ENSMUSG00000076612

Gene Name

immunoglobulin heavy constant gamma 2C

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

IGL02560

Quality Score

Status

Chromosome

Chromosomal Location

113251009-113252552 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 113251504 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 208 (C208S)

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000103416
AA Change: C208S

SMART Domains

Protein: ENSMUSP00000100212
Gene: ENSMUSG00000076612
AA Change: C208S

Domain	Start	End	E-Value	Type
IGc1	21	91	2.4e-15	SMART
IG_like	143	218	1.64e-2	SMART
IGc1	249	322	1.97e-34	SMART
transmembrane domain	350	372	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000195192
AA Change: C208S

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ano4	C	T	10: 88,814,603 (GRCm39)	W660*	probably null	Het
Atp9b	T	C	18: 80,805,413 (GRCm39)	D715G	probably benign	Het
Catsper1	T	C	19: 5,386,216 (GRCm39)	S150P	possibly damaging	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cldn19	G	A	4: 119,112,921 (GRCm39)	W51*	probably null	Het
Ddx31	T	C	2: 28,765,838 (GRCm39)	I512T	probably damaging	Het
Dsc2	G	T	18: 20,178,596 (GRCm39)	D269E	probably damaging	Het
Dsg1b	T	C	18: 20,542,235 (GRCm39)	V914A	possibly damaging	Het
Etl4	A	G	2: 20,748,529 (GRCm39)	E420G	probably damaging	Het
Foxa2	A	G	2: 147,885,951 (GRCm39)	L113P	probably benign	Het
Gm6034	T	G	17: 36,367,356 (GRCm39)		probably benign	Het
Gtf3c4	A	T	2: 28,724,279 (GRCm39)	Y343*	probably null	Het
Hhip	A	T	8: 80,713,638 (GRCm39)	Y563N	probably damaging	Het
Lipo2	A	G	19: 33,708,348 (GRCm39)	L222P	possibly damaging	Het
Myb	A	T	10: 21,028,347 (GRCm39)	L172Q	probably damaging	Het
Nipal3	A	T	4: 135,207,015 (GRCm39)	Y60N	probably damaging	Het
Npas2	A	T	1: 39,373,042 (GRCm39)		probably benign	Het
Or5h26	G	T	16: 58,987,891 (GRCm39)	S205*	probably null	Het
Or8k16	T	A	2: 85,519,863 (GRCm39)	V30D	possibly damaging	Het
Or8k39	A	T	2: 86,563,578 (GRCm39)	I126N	probably damaging	Het
Pdxdc1	T	C	16: 13,657,596 (GRCm39)	D532G	probably benign	Het
Pwp2	T	C	10: 78,014,899 (GRCm39)	S362G	probably damaging	Het
Senp5	A	G	16: 31,808,210 (GRCm39)	V348A	probably benign	Het
Slc25a37	T	C	14: 69,482,741 (GRCm39)	T187A	probably benign	Het
Svil	A	G	18: 5,049,379 (GRCm39)	I219V	probably benign	Het
Tcf4	A	G	18: 69,776,093 (GRCm39)		probably benign	Het
Tex15	T	C	8: 34,071,779 (GRCm39)	V2442A	probably benign	Het
Tomm70a	T	C	16: 56,970,212 (GRCm39)	L530S	probably benign	Het
Ulbp3	A	G	10: 3,075,866 (GRCm39)		noncoding transcript	Het
Wscd2	A	T	5: 113,699,045 (GRCm39)	D200V	probably benign	Het
Zfp952	C	T	17: 33,221,793 (GRCm39)	Q53*	probably null	Het

Other mutations in Ighg2c

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL02087:Ighg2c	APN	12	113,248,986 (GRCm39)	unclassified	probably benign
IGL03339:Ighg2c	APN	12	113,251,614 (GRCm39)	missense	unknown
R0047:Ighg2c	UTSW	12	113,251,788 (GRCm39)	splice site	probably benign
R0047:Ighg2c	UTSW	12	113,251,788 (GRCm39)	splice site	probably benign
R0415:Ighg2c	UTSW	12	113,251,530 (GRCm39)	missense	unknown
R0571:Ighg2c	UTSW	12	113,252,382 (GRCm39)	nonsense	probably null
R0634:Ighg2c	UTSW	12	113,251,584 (GRCm39)	missense	unknown
R0893:Ighg2c	UTSW	12	113,251,053 (GRCm39)	missense	unknown
R1169:Ighg2c	UTSW	12	113,249,572 (GRCm39)	unclassified	probably benign
R3895:Ighg2c	UTSW	12	113,251,278 (GRCm39)	missense	unknown
R5065:Ighg2c	UTSW	12	113,251,708 (GRCm39)	missense	unknown
R6407:Ighg2c	UTSW	12	113,252,271 (GRCm39)	missense	unknown
R6846:Ighg2c	UTSW	12	113,251,930 (GRCm39)	missense	unknown
R7052:Ighg2c	UTSW	12	113,252,343 (GRCm39)	missense
R7231:Ighg2c	UTSW	12	113,251,636 (GRCm39)	missense
R7513:Ighg2c	UTSW	12	113,252,471 (GRCm39)	missense
R8783:Ighg2c	UTSW	12	113,252,412 (GRCm39)	missense
R9175:Ighg2c	UTSW	12	113,252,499 (GRCm39)	missense
R9419:Ighg2c	UTSW	12	113,251,015 (GRCm39)	critical splice donor site	probably benign
Z1177:Ighg2c	UTSW	12	113,251,300 (GRCm39)	missense

Posted On

2015-04-16