Incidental Mutation 'IGL02560:Zfp952'
| ID |
298198 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp952
|
| Ensembl Gene |
ENSMUSG00000053390 |
| Gene Name |
zinc finger protein 952 |
| Synonyms |
C920016K16Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.094)
|
| Stock # |
IGL02560
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
33212103-33224431 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to T
at 33221793 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 53
(Q53*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123066
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087666]
[ENSMUST00000157017]
|
| AlphaFold |
B0V2W4 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000087666
AA Change: Q91*
|
| SMART Domains |
Protein: ENSMUSP00000084949
Gene: ENSMUSG00000053390
AA Change: Q91*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
73 |
4.6e-14 |
SMART |
|
ZnF_C2H2
|
251 |
273 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
279 |
301 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
307 |
329 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
335 |
357 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
363 |
385 |
9.44e-2 |
SMART |
|
ZnF_C2H2
|
391 |
413 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
419 |
441 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
447 |
469 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
475 |
497 |
1.43e-1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141815
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000157017
AA Change: Q53*
|
| SMART Domains |
Protein: ENSMUSP00000123066
Gene: ENSMUSG00000053390
AA Change: Q53*
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
35 |
4e-17 |
BLAST |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
All alleles(2) : Gene trapped(2) |
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ano4 |
C |
T |
10: 88,814,603 (GRCm39) |
W660* |
probably null |
Het |
| Atp9b |
T |
C |
18: 80,805,413 (GRCm39) |
D715G |
probably benign |
Het |
| Catsper1 |
T |
C |
19: 5,386,216 (GRCm39) |
S150P |
possibly damaging |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Cldn19 |
G |
A |
4: 119,112,921 (GRCm39) |
W51* |
probably null |
Het |
| Ddx31 |
T |
C |
2: 28,765,838 (GRCm39) |
I512T |
probably damaging |
Het |
| Dsc2 |
G |
T |
18: 20,178,596 (GRCm39) |
D269E |
probably damaging |
Het |
| Dsg1b |
T |
C |
18: 20,542,235 (GRCm39) |
V914A |
possibly damaging |
Het |
| Etl4 |
A |
G |
2: 20,748,529 (GRCm39) |
E420G |
probably damaging |
Het |
| Foxa2 |
A |
G |
2: 147,885,951 (GRCm39) |
L113P |
probably benign |
Het |
| Gm6034 |
T |
G |
17: 36,367,356 (GRCm39) |
|
probably benign |
Het |
| Gtf3c4 |
A |
T |
2: 28,724,279 (GRCm39) |
Y343* |
probably null |
Het |
| Hhip |
A |
T |
8: 80,713,638 (GRCm39) |
Y563N |
probably damaging |
Het |
| Ighg2c |
A |
T |
12: 113,251,504 (GRCm39) |
C208S |
unknown |
Het |
| Lipo2 |
A |
G |
19: 33,708,348 (GRCm39) |
L222P |
possibly damaging |
Het |
| Myb |
A |
T |
10: 21,028,347 (GRCm39) |
L172Q |
probably damaging |
Het |
| Nipal3 |
A |
T |
4: 135,207,015 (GRCm39) |
Y60N |
probably damaging |
Het |
| Npas2 |
A |
T |
1: 39,373,042 (GRCm39) |
|
probably benign |
Het |
| Or5h26 |
G |
T |
16: 58,987,891 (GRCm39) |
S205* |
probably null |
Het |
| Or8k16 |
T |
A |
2: 85,519,863 (GRCm39) |
V30D |
possibly damaging |
Het |
| Or8k39 |
A |
T |
2: 86,563,578 (GRCm39) |
I126N |
probably damaging |
Het |
| Pdxdc1 |
T |
C |
16: 13,657,596 (GRCm39) |
D532G |
probably benign |
Het |
| Pwp2 |
T |
C |
10: 78,014,899 (GRCm39) |
S362G |
probably damaging |
Het |
| Senp5 |
A |
G |
16: 31,808,210 (GRCm39) |
V348A |
probably benign |
Het |
| Slc25a37 |
T |
C |
14: 69,482,741 (GRCm39) |
T187A |
probably benign |
Het |
| Svil |
A |
G |
18: 5,049,379 (GRCm39) |
I219V |
probably benign |
Het |
| Tcf4 |
A |
G |
18: 69,776,093 (GRCm39) |
|
probably benign |
Het |
| Tex15 |
T |
C |
8: 34,071,779 (GRCm39) |
V2442A |
probably benign |
Het |
| Tomm70a |
T |
C |
16: 56,970,212 (GRCm39) |
L530S |
probably benign |
Het |
| Ulbp3 |
A |
G |
10: 3,075,866 (GRCm39) |
|
noncoding transcript |
Het |
| Wscd2 |
A |
T |
5: 113,699,045 (GRCm39) |
D200V |
probably benign |
Het |
|
| Other mutations in Zfp952 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01865:Zfp952
|
APN |
17 |
33,221,791 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03056:Zfp952
|
APN |
17 |
33,221,740 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03151:Zfp952
|
APN |
17 |
33,221,982 (GRCm39) |
missense |
probably benign |
0.01 |
|
0152:Zfp952
|
UTSW |
17 |
33,222,195 (GRCm39) |
splice site |
probably null |
|
|
R0508:Zfp952
|
UTSW |
17 |
33,221,979 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1936:Zfp952
|
UTSW |
17 |
33,222,643 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R3882:Zfp952
|
UTSW |
17 |
33,220,949 (GRCm39) |
nonsense |
probably null |
|
|
R4560:Zfp952
|
UTSW |
17 |
33,222,928 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4649:Zfp952
|
UTSW |
17 |
33,221,899 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7103:Zfp952
|
UTSW |
17 |
33,222,606 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7207:Zfp952
|
UTSW |
17 |
33,222,489 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7209:Zfp952
|
UTSW |
17 |
33,222,444 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7508:Zfp952
|
UTSW |
17 |
33,222,756 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7699:Zfp952
|
UTSW |
17 |
33,220,983 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8424:Zfp952
|
UTSW |
17 |
33,222,191 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8445:Zfp952
|
UTSW |
17 |
33,222,552 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8711:Zfp952
|
UTSW |
17 |
33,222,004 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8919:Zfp952
|
UTSW |
17 |
33,220,628 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8970:Zfp952
|
UTSW |
17 |
33,221,810 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Zfp952
|
UTSW |
17 |
33,222,078 (GRCm39) |
nonsense |
probably null |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation