Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02543:Vmn2r76'

298278

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r76

Ensembl Gene

ENSMUSG00000091239

Gene Name

vomeronasal 2, receptor 76

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL02543

Quality Score

Status

Chromosome

Chromosomal Location

86225206-86246201 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 86230148 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 315 (S315P)

Ref Sequence

ENSEMBL: ENSMUSP00000127309 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165771]

AlphaFold

E9Q3F5

Predicted Effect

probably benign
Transcript: ENSMUST00000165771
AA Change: S315P

PolyPhen 2 Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000127309
Gene: ENSMUSG00000091239
AA Change: S315P

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	78	470	1.2e-29	PFAM
low complexity region	476	489	N/A	INTRINSIC
Pfam:NCD3G	513	565	3.7e-22	PFAM
Pfam:7tm_3	598	833	1.4e-52	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	G	T	19: 31,918,095	A193S	probably damaging	Het
Adcy4	T	C	14: 55,769,170	T1069A	probably benign	Het
Arg2	A	T	12: 79,150,759	I184F	probably benign	Het
Asb18	G	A	1: 90,014,391	P63S	probably damaging	Het
Cd163l1	A	G	7: 140,220,578	M91V	probably benign	Het
Cep85	T	C	4: 134,156,323	H85R	possibly damaging	Het
Chfr	A	G	5: 110,143,547		probably null	Het
Cog2	A	G	8: 124,529,959	N148S	probably benign	Het
Csgalnact1	T	C	8: 68,461,068	T162A	probably damaging	Het
Ddi1	C	T	9: 6,266,183	G62D	possibly damaging	Het
Dhx33	T	C	11: 70,987,240	Y435C	probably damaging	Het
Dsc3	A	T	18: 19,965,828	C765S	probably benign	Het
Egfem1	T	A	3: 29,668,380	D362E	probably benign	Het
Gm10093	A	G	17: 78,491,874	E98G	probably damaging	Het
Gm28040	A	T	1: 133,319,331	I26F	possibly damaging	Het
Gm28778	T	C	1: 53,299,043	M22T	probably benign	Het
Hipk2	A	G	6: 38,703,501	I968T	possibly damaging	Het
Hlx	T	G	1: 184,730,751	S235R	probably damaging	Het
Jag1	T	C	2: 137,091,947		probably benign	Het
Kdr	A	G	5: 75,964,947		probably benign	Het
Klhl3	T	C	13: 58,018,871	E435G	probably damaging	Het
L3mbtl4	T	C	17: 68,461,612		probably benign	Het
Large1	T	A	8: 73,048,414	M223L	probably benign	Het
Lrp1b	T	C	2: 40,870,401	K2838E	possibly damaging	Het
Ncan	T	C	8: 70,108,571	D582G	probably benign	Het
Nedd9	T	C	13: 41,316,735	D314G	probably damaging	Het
Nip7	T	C	8: 107,058,193		probably benign	Het
Olfr1408	T	G	1: 173,130,334	K294N	probably damaging	Het
Olfr629	A	T	7: 103,740,503	C246S	possibly damaging	Het
Olfr8	C	A	10: 78,955,939	H245N	probably damaging	Het
P3h1	T	C	4: 119,237,856		probably benign	Het
Pcp4l1	C	T	1: 171,175,564		probably benign	Het
Plekhm2	C	T	4: 141,642,019	G118D	probably benign	Het
Prkg1	T	C	19: 30,624,734	D374G	possibly damaging	Het
Ptcd1	A	G	5: 145,154,687	L534P	possibly damaging	Het
Rnf123	A	G	9: 108,066,348	S563P	probably damaging	Het
Sdk2	A	T	11: 113,868,921	I418N	possibly damaging	Het
Slc26a4	A	G	12: 31,528,689	I655T	possibly damaging	Het
Syne1	T	C	10: 5,043,618	K524R	probably damaging	Het
Tanc1	G	T	2: 59,833,258	G1120C	probably damaging	Het
Tbc1d22a	C	T	15: 86,239,171	A135V	probably benign	Het
Tenm3	A	C	8: 48,298,956	W942G	probably damaging	Het
Thsd7b	G	A	1: 130,165,103	V1247I	probably benign	Het
Treml1	A	G	17: 48,360,431	T115A	possibly damaging	Het
Ttn	T	C	2: 76,709,962	T34227A	probably benign	Het
Ugt2b38	T	A	5: 87,423,483	D230V	probably benign	Het
Vmn1r203	G	A	13: 22,524,904	G285D	probably damaging	Het
Vmn2r98	T	G	17: 19,065,821	S194A	probably benign	Het
Wdr1	G	A	5: 38,545,822	S137F	probably damaging	Het
Wnt7b	C	T	15: 85,558,896		probably benign	Het
Zfp668	A	T	7: 127,868,322	C27*	probably null	Het

Other mutations in Vmn2r76

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00969:Vmn2r76	APN	7	86228717	missense	probably benign
IGL01374:Vmn2r76	APN	7	86225649	missense	probably benign	0.02
IGL01419:Vmn2r76	APN	7	86225702	missense	probably benign	0.32
IGL01627:Vmn2r76	APN	7	86225663	missense	probably damaging	1.00
IGL01730:Vmn2r76	APN	7	86230198	missense	probably benign	0.02
IGL01957:Vmn2r76	APN	7	86228717	missense	probably benign
IGL02214:Vmn2r76	APN	7	86229930	missense	probably benign	0.07
IGL02489:Vmn2r76	APN	7	86228863	missense	probably benign	0.41
IGL02579:Vmn2r76	APN	7	86228753	nonsense	probably null
IGL02598:Vmn2r76	APN	7	86228671	missense	probably benign	0.05
IGL02720:Vmn2r76	APN	7	86225706	missense	probably benign	0.35
IGL02745:Vmn2r76	APN	7	86230287	missense	probably benign	0.06
IGL03393:Vmn2r76	APN	7	86229826	missense	probably benign	0.01
R0483:Vmn2r76	UTSW	7	86225751	missense	probably damaging	1.00
R0513:Vmn2r76	UTSW	7	86228779	missense	probably benign	0.01
R0528:Vmn2r76	UTSW	7	86230298	missense	possibly damaging	0.80
R0601:Vmn2r76	UTSW	7	86226115	critical splice acceptor site	probably null
R0662:Vmn2r76	UTSW	7	86230370	missense	probably benign	0.39
R0883:Vmn2r76	UTSW	7	86228696	missense	probably benign	0.00
R1532:Vmn2r76	UTSW	7	86230246	missense	probably benign	0.02
R1694:Vmn2r76	UTSW	7	86230148	missense	probably benign	0.06
R1696:Vmn2r76	UTSW	7	86231256	missense	possibly damaging	0.56
R2135:Vmn2r76	UTSW	7	86231011	missense	probably benign	0.02
R2151:Vmn2r76	UTSW	7	86230484	missense	probably benign
R2181:Vmn2r76	UTSW	7	86225535	missense	probably benign	0.00
R2268:Vmn2r76	UTSW	7	86230499	missense	probably benign	0.03
R2877:Vmn2r76	UTSW	7	86225993	missense	probably benign	0.00
R3155:Vmn2r76	UTSW	7	86225751	missense	probably damaging	1.00
R3746:Vmn2r76	UTSW	7	86225555	missense	probably benign	0.11
R3799:Vmn2r76	UTSW	7	86226036	missense	probably benign	0.00
R3825:Vmn2r76	UTSW	7	86231207	missense	probably benign	0.10
R4058:Vmn2r76	UTSW	7	86230300	missense	probably benign	0.00
R4237:Vmn2r76	UTSW	7	86230532	missense	probably benign	0.00
R4404:Vmn2r76	UTSW	7	86228303	missense	probably benign	0.16
R4796:Vmn2r76	UTSW	7	86230444	missense	possibly damaging	0.95
R4838:Vmn2r76	UTSW	7	86225525	missense	probably damaging	1.00
R5175:Vmn2r76	UTSW	7	86228707	missense	probably benign	0.00
R5268:Vmn2r76	UTSW	7	86226059	missense	probably damaging	1.00
R5381:Vmn2r76	UTSW	7	86225288	missense	probably damaging	1.00
R5531:Vmn2r76	UTSW	7	86225449	missense	probably damaging	1.00
R5566:Vmn2r76	UTSW	7	86226078	missense	probably damaging	1.00
R5646:Vmn2r76	UTSW	7	86226053	missense	probably damaging	0.98
R5664:Vmn2r76	UTSW	7	86245994	critical splice donor site	probably null
R5818:Vmn2r76	UTSW	7	86229934	missense	probably benign	0.00
R6093:Vmn2r76	UTSW	7	86228261	nonsense	probably null
R6651:Vmn2r76	UTSW	7	86228851	missense	possibly damaging	0.64
R6741:Vmn2r76	UTSW	7	86230352	missense	probably benign
R6750:Vmn2r76	UTSW	7	86225906	missense	probably damaging	1.00
R7082:Vmn2r76	UTSW	7	86225232	missense	probably benign	0.01
R7136:Vmn2r76	UTSW	7	86228767	missense	probably benign	0.06
R7524:Vmn2r76	UTSW	7	86225369	missense	probably benign	0.22
R7524:Vmn2r76	UTSW	7	86230166	missense	probably benign	0.00
R7611:Vmn2r76	UTSW	7	86230180	missense	probably benign	0.04
R7833:Vmn2r76	UTSW	7	86228684	missense	probably benign
R8002:Vmn2r76	UTSW	7	86230063	missense	probably benign	0.05
R8021:Vmn2r76	UTSW	7	86225750	missense	probably damaging	1.00
R8023:Vmn2r76	UTSW	7	86229820	missense	probably benign	0.00
R8250:Vmn2r76	UTSW	7	86226023	missense	possibly damaging	0.82
R8428:Vmn2r76	UTSW	7	86225271	missense	possibly damaging	0.63
R8874:Vmn2r76	UTSW	7	86228791	missense	probably damaging	1.00
R9139:Vmn2r76	UTSW	7	86229962	missense	probably benign	0.02
R9357:Vmn2r76	UTSW	7	86231220	missense	probably benign	0.43
Z1176:Vmn2r76	UTSW	7	86246063	missense	probably benign	0.39

Posted On

2015-04-16