Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02543:Gm10093'

298282

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm10093

Ensembl Gene

ENSMUSG00000061062

Gene Name

predicted pseudogene 10093

Synonyms

EG15181

Accession Numbers

Essential gene?

Probably essential (E-score: 0.856) question?

Stock #

IGL02543

Quality Score

Status

Chromosome

Chromosomal Location

78491565-78493541 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 78491874 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 98 (E98G)

Ref Sequence

ENSEMBL: ENSMUSP00000078339 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079363]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000079363
AA Change: E98G

PolyPhen 2 Score 0.969 (Sensitivity: 0.77; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000078339
Gene: ENSMUSG00000061062
AA Change: E98G

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	18	320	3.2e-84	PFAM
low complexity region	390	402	N/A	INTRINSIC
low complexity region	417	430	N/A	INTRINSIC
low complexity region	443	471	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A1cf	G	T	19: 31,918,095	A193S	probably damaging	Het
Adcy4	T	C	14: 55,769,170	T1069A	probably benign	Het
Arg2	A	T	12: 79,150,759	I184F	probably benign	Het
Asb18	G	A	1: 90,014,391	P63S	probably damaging	Het
Cd163l1	A	G	7: 140,220,578	M91V	probably benign	Het
Cep85	T	C	4: 134,156,323	H85R	possibly damaging	Het
Chfr	A	G	5: 110,143,547		probably null	Het
Cog2	A	G	8: 124,529,959	N148S	probably benign	Het
Csgalnact1	T	C	8: 68,461,068	T162A	probably damaging	Het
Ddi1	C	T	9: 6,266,183	G62D	possibly damaging	Het
Dhx33	T	C	11: 70,987,240	Y435C	probably damaging	Het
Dsc3	A	T	18: 19,965,828	C765S	probably benign	Het
Egfem1	T	A	3: 29,668,380	D362E	probably benign	Het
Gm28040	A	T	1: 133,319,331	I26F	possibly damaging	Het
Gm28778	T	C	1: 53,299,043	M22T	probably benign	Het
Hipk2	A	G	6: 38,703,501	I968T	possibly damaging	Het
Hlx	T	G	1: 184,730,751	S235R	probably damaging	Het
Jag1	T	C	2: 137,091,947		probably benign	Het
Kdr	A	G	5: 75,964,947		probably benign	Het
Klhl3	T	C	13: 58,018,871	E435G	probably damaging	Het
L3mbtl4	T	C	17: 68,461,612		probably benign	Het
Large1	T	A	8: 73,048,414	M223L	probably benign	Het
Lrp1b	T	C	2: 40,870,401	K2838E	possibly damaging	Het
Ncan	T	C	8: 70,108,571	D582G	probably benign	Het
Nedd9	T	C	13: 41,316,735	D314G	probably damaging	Het
Nip7	T	C	8: 107,058,193		probably benign	Het
Olfr1408	T	G	1: 173,130,334	K294N	probably damaging	Het
Olfr629	A	T	7: 103,740,503	C246S	possibly damaging	Het
Olfr8	C	A	10: 78,955,939	H245N	probably damaging	Het
P3h1	T	C	4: 119,237,856		probably benign	Het
Pcp4l1	C	T	1: 171,175,564		probably benign	Het
Plekhm2	C	T	4: 141,642,019	G118D	probably benign	Het
Prkg1	T	C	19: 30,624,734	D374G	possibly damaging	Het
Ptcd1	A	G	5: 145,154,687	L534P	possibly damaging	Het
Rnf123	A	G	9: 108,066,348	S563P	probably damaging	Het
Sdk2	A	T	11: 113,868,921	I418N	possibly damaging	Het
Slc26a4	A	G	12: 31,528,689	I655T	possibly damaging	Het
Syne1	T	C	10: 5,043,618	K524R	probably damaging	Het
Tanc1	G	T	2: 59,833,258	G1120C	probably damaging	Het
Tbc1d22a	C	T	15: 86,239,171	A135V	probably benign	Het
Tenm3	A	C	8: 48,298,956	W942G	probably damaging	Het
Thsd7b	G	A	1: 130,165,103	V1247I	probably benign	Het
Treml1	A	G	17: 48,360,431	T115A	possibly damaging	Het
Ttn	T	C	2: 76,709,962	T34227A	probably benign	Het
Ugt2b38	T	A	5: 87,423,483	D230V	probably benign	Het
Vmn1r203	G	A	13: 22,524,904	G285D	probably damaging	Het
Vmn2r76	A	G	7: 86,230,148	S315P	probably benign	Het
Vmn2r98	T	G	17: 19,065,821	S194A	probably benign	Het
Wdr1	G	A	5: 38,545,822	S137F	probably damaging	Het
Wnt7b	C	T	15: 85,558,896		probably benign	Het
Zfp668	A	T	7: 127,868,322	C27*	probably null	Het

Other mutations in Gm10093

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01936:Gm10093	APN	17	78492129	missense	probably damaging	1.00
IGL01983:Gm10093	APN	17	78492853	missense	probably benign
buttress	UTSW	17	78492914	missense	possibly damaging	0.91
Chartre	UTSW	17	78492540	missense	probably damaging	0.99
R1174:Gm10093	UTSW	17	78492078	missense	probably benign	0.01
R1605:Gm10093	UTSW	17	78492108	missense	probably damaging	0.98
R2416:Gm10093	UTSW	17	78492516	missense	probably damaging	1.00
R2919:Gm10093	UTSW	17	78492846	missense	probably damaging	0.98
R2920:Gm10093	UTSW	17	78492846	missense	probably damaging	0.98
R3846:Gm10093	UTSW	17	78492972	missense	possibly damaging	0.91
R4544:Gm10093	UTSW	17	78492959	missense	probably benign	0.02
R4546:Gm10093	UTSW	17	78492959	missense	probably benign	0.02
R5223:Gm10093	UTSW	17	78492438	missense	probably benign	0.02
R5297:Gm10093	UTSW	17	78492758	missense	probably benign
R6164:Gm10093	UTSW	17	78492287	missense	probably damaging	0.99
R6568:Gm10093	UTSW	17	78492588	missense	probably damaging	1.00
R6726:Gm10093	UTSW	17	78492858	missense	probably damaging	0.99
R6901:Gm10093	UTSW	17	78492660	missense	probably benign	0.07
R6923:Gm10093	UTSW	17	78492914	missense	possibly damaging	0.91
R7838:Gm10093	UTSW	17	78492018	missense	probably damaging	1.00
R8002:Gm10093	UTSW	17	78492287	missense	probably damaging	0.99
R8728:Gm10093	UTSW	17	78492903	missense	probably benign	0.01
R8821:Gm10093	UTSW	17	78492540	missense	probably damaging	0.99
R8920:Gm10093	UTSW	17	78491742	missense	probably benign	0.37
R9618:Gm10093	UTSW	17	78491685	missense	probably damaging	1.00
R9649:Gm10093	UTSW	17	78491646	missense	probably benign	0.03
X0060:Gm10093	UTSW	17	78492128	missense	probably damaging	0.99

Posted On

2015-04-16