Incidental Mutation 'IGL02558:Or1e17'
ID 298366
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1e17
Ensembl Gene ENSMUSG00000069816
Gene Name olfactory receptor family 1 subfamily E member 17
Synonyms GA_x6K02T2P1NL-4097159-4098136, MTPCR50, MOR135-27, Olfr23
Accession Numbers
Essential gene? Probably non essential (E-score: 0.220) question?
Stock # IGL02558
Quality Score
Status
Chromosome 11
Chromosomal Location 73827503-73833484 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73831651 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 193 (H193L)
Ref Sequence ENSEMBL: ENSMUSP00000150593 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092917] [ENSMUST00000214210]
AlphaFold Q7TRX4
Predicted Effect probably benign
Transcript: ENSMUST00000092917
AA Change: H193L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000090596
Gene: ENSMUSG00000069816
AA Change: H193L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 7.8e-60 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.8e-6 PFAM
Pfam:7tm_1 41 290 9.3e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214210
AA Change: H193L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700109H08Rik A C 5: 3,632,194 (GRCm39) *25C probably null Het
Abca13 T C 11: 9,349,387 (GRCm39) Y3654H probably damaging Het
Ankle1 T C 8: 71,861,636 (GRCm39) F438S probably damaging Het
Atp10a A T 7: 58,469,390 (GRCm39) R1080S probably damaging Het
Ccdc51 A T 9: 108,921,252 (GRCm39) N380Y probably damaging Het
Ccr8 A T 9: 119,923,724 (GRCm39) I280F probably benign Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cep162 T C 9: 87,107,786 (GRCm39) T535A probably benign Het
Cep162 G T 9: 87,107,779 (GRCm39) T537N probably benign Het
Cfap52 T C 11: 67,844,964 (GRCm39) D35G probably benign Het
Cmip G A 8: 118,175,827 (GRCm39) S530N probably damaging Het
Col9a3 A T 2: 180,248,599 (GRCm39) probably null Het
Csf3r T C 4: 125,931,928 (GRCm39) probably benign Het
Csk C T 9: 57,537,546 (GRCm39) E123K probably benign Het
Csrnp3 G A 2: 65,852,573 (GRCm39) E322K probably damaging Het
Ddx11 A T 17: 66,455,667 (GRCm39) I663F probably damaging Het
Dnah1 T A 14: 30,996,336 (GRCm39) M2667L possibly damaging Het
Foxred1 T C 9: 35,121,429 (GRCm39) K40E probably damaging Het
Gata2 C T 6: 88,176,762 (GRCm39) P74S probably benign Het
Gdf10 T G 14: 33,645,937 (GRCm39) C29G probably benign Het
Hectd4 A G 5: 121,482,848 (GRCm39) E3133G probably benign Het
Ints8 G A 4: 11,218,771 (GRCm39) R784W probably damaging Het
Lrriq1 T C 10: 102,982,144 (GRCm39) E1392G probably damaging Het
Muc19 T C 15: 91,781,816 (GRCm39) noncoding transcript Het
Myom2 A T 8: 15,164,237 (GRCm39) D1044V probably benign Het
Nphp4 G T 4: 152,639,988 (GRCm39) R958L probably damaging Het
Nup205 C T 6: 35,166,859 (GRCm39) P293S probably damaging Het
Or10ag60 T C 2: 87,437,903 (GRCm39) I57T probably benign Het
Plxdc2 A G 2: 16,674,409 (GRCm39) probably benign Het
Pwp2 T C 10: 78,014,899 (GRCm39) S362G probably damaging Het
Siglec1 G T 2: 130,916,915 (GRCm39) S1113R possibly damaging Het
Sirpa A G 2: 129,471,989 (GRCm39) E472G probably damaging Het
Slc39a4 G T 15: 76,498,403 (GRCm39) L345M probably damaging Het
Snx27 C T 3: 94,410,188 (GRCm39) R496Q probably damaging Het
Stard9 A G 2: 120,527,388 (GRCm39) H1215R possibly damaging Het
Stau1 A G 2: 166,792,768 (GRCm39) Y371H probably benign Het
Sult2a1 A C 7: 13,566,520 (GRCm39) W152G probably benign Het
Syt16 A T 12: 74,281,832 (GRCm39) K319* probably null Het
Tcf7 T A 11: 52,144,797 (GRCm39) probably benign Het
Tfdp1 A G 8: 13,419,546 (GRCm39) N92D possibly damaging Het
Zfp13 C T 17: 23,795,072 (GRCm39) A493T probably benign Het
Other mutations in Or1e17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01546:Or1e17 APN 11 73,832,020 (GRCm39) missense probably benign
IGL02290:Or1e17 APN 11 73,831,695 (GRCm39) missense probably benign 0.00
IGL02301:Or1e17 APN 11 73,831,894 (GRCm39) missense possibly damaging 0.79
IGL02303:Or1e17 APN 11 73,831,276 (GRCm39) missense possibly damaging 0.87
IGL02510:Or1e17 APN 11 73,831,831 (GRCm39) missense probably damaging 1.00
IGL02712:Or1e17 APN 11 73,831,756 (GRCm39) missense probably benign 0.12
IGL02795:Or1e17 APN 11 73,831,755 (GRCm39) missense probably benign 0.05
IGL02800:Or1e17 APN 11 73,831,942 (GRCm39) missense probably damaging 1.00
IGL03350:Or1e17 APN 11 73,831,664 (GRCm39) missense probably damaging 0.99
R0277:Or1e17 UTSW 11 73,831,773 (GRCm39) missense probably benign 0.28
R0323:Or1e17 UTSW 11 73,831,773 (GRCm39) missense probably benign 0.28
R0333:Or1e17 UTSW 11 73,831,593 (GRCm39) missense possibly damaging 0.78
R0389:Or1e17 UTSW 11 73,831,879 (GRCm39) missense probably benign 0.12
R0391:Or1e17 UTSW 11 73,831,935 (GRCm39) missense probably damaging 1.00
R0723:Or1e17 UTSW 11 73,831,096 (GRCm39) missense probably benign 0.00
R1469:Or1e17 UTSW 11 73,831,383 (GRCm39) missense probably benign 0.05
R1469:Or1e17 UTSW 11 73,831,383 (GRCm39) missense probably benign 0.05
R1900:Or1e17 UTSW 11 73,831,486 (GRCm39) missense possibly damaging 0.79
R2363:Or1e17 UTSW 11 73,831,182 (GRCm39) missense possibly damaging 0.96
R4236:Or1e17 UTSW 11 73,831,182 (GRCm39) missense possibly damaging 0.96
R4630:Or1e17 UTSW 11 73,831,822 (GRCm39) missense probably damaging 1.00
R4717:Or1e17 UTSW 11 73,831,641 (GRCm39) missense possibly damaging 0.86
R4801:Or1e17 UTSW 11 73,831,696 (GRCm39) missense possibly damaging 0.88
R4802:Or1e17 UTSW 11 73,831,696 (GRCm39) missense possibly damaging 0.88
R4964:Or1e17 UTSW 11 73,832,028 (GRCm39) missense probably benign 0.04
R5119:Or1e17 UTSW 11 73,831,378 (GRCm39) missense possibly damaging 0.76
R5470:Or1e17 UTSW 11 73,831,696 (GRCm39) missense probably benign 0.06
R6196:Or1e17 UTSW 11 73,831,635 (GRCm39) missense possibly damaging 0.86
R6551:Or1e17 UTSW 11 73,831,129 (GRCm39) missense probably benign 0.11
R7695:Or1e17 UTSW 11 73,831,720 (GRCm39) missense possibly damaging 0.94
R7979:Or1e17 UTSW 11 73,831,401 (GRCm39) missense probably benign 0.00
R8074:Or1e17 UTSW 11 73,831,213 (GRCm39) missense possibly damaging 0.78
R8834:Or1e17 UTSW 11 73,831,164 (GRCm39) missense possibly damaging 0.59
R9344:Or1e17 UTSW 11 73,831,744 (GRCm39) missense possibly damaging 0.94
R9352:Or1e17 UTSW 11 73,831,470 (GRCm39) missense probably benign 0.12
R9800:Or1e17 UTSW 11 73,831,986 (GRCm39) missense probably benign 0.01
X0065:Or1e17 UTSW 11 73,831,150 (GRCm39) missense possibly damaging 0.59
Z1088:Or1e17 UTSW 11 73,831,964 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16