Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02558:Syt16'

298397

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Syt16

Ensembl Gene

ENSMUSG00000044912

Gene Name

synaptotagmin XVI

Synonyms

syt14r, Strep14, Syt14l

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02558

Quality Score

Status

Chromosome

Chromosomal Location

74044490-74314690 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 74281832 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Stop codon at position 319 (K319*)

Ref Sequence

ENSEMBL: ENSMUSP00000152623 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110451] [ENSMUST00000221220]

AlphaFold

Q7TN83

Predicted Effect

probably benign
Transcript: ENSMUST00000110451

SMART Domains

Protein: ENSMUSP00000106081
Gene: ENSMUSG00000044912

Domain	Start	End	E-Value	Type
transmembrane domain	9	31	N/A	INTRINSIC
low complexity region	70	83	N/A	INTRINSIC
C2	270	372	8.91e-4	SMART
low complexity region	386	407	N/A	INTRINSIC
C2	425	541	7.07e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189898

Predicted Effect

probably null
Transcript: ENSMUST00000221220
AA Change: K319*

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700109H08Rik	A	C	5: 3,632,194 (GRCm39)	*25C	probably null	Het
Abca13	T	C	11: 9,349,387 (GRCm39)	Y3654H	probably damaging	Het
Ankle1	T	C	8: 71,861,636 (GRCm39)	F438S	probably damaging	Het
Atp10a	A	T	7: 58,469,390 (GRCm39)	R1080S	probably damaging	Het
Ccdc51	A	T	9: 108,921,252 (GRCm39)	N380Y	probably damaging	Het
Ccr8	A	T	9: 119,923,724 (GRCm39)	I280F	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cep162	T	C	9: 87,107,786 (GRCm39)	T535A	probably benign	Het
Cep162	G	T	9: 87,107,779 (GRCm39)	T537N	probably benign	Het
Cfap52	T	C	11: 67,844,964 (GRCm39)	D35G	probably benign	Het
Cmip	G	A	8: 118,175,827 (GRCm39)	S530N	probably damaging	Het
Col9a3	A	T	2: 180,248,599 (GRCm39)		probably null	Het
Csf3r	T	C	4: 125,931,928 (GRCm39)		probably benign	Het
Csk	C	T	9: 57,537,546 (GRCm39)	E123K	probably benign	Het
Csrnp3	G	A	2: 65,852,573 (GRCm39)	E322K	probably damaging	Het
Ddx11	A	T	17: 66,455,667 (GRCm39)	I663F	probably damaging	Het
Dnah1	T	A	14: 30,996,336 (GRCm39)	M2667L	possibly damaging	Het
Foxred1	T	C	9: 35,121,429 (GRCm39)	K40E	probably damaging	Het
Gata2	C	T	6: 88,176,762 (GRCm39)	P74S	probably benign	Het
Gdf10	T	G	14: 33,645,937 (GRCm39)	C29G	probably benign	Het
Hectd4	A	G	5: 121,482,848 (GRCm39)	E3133G	probably benign	Het
Ints8	G	A	4: 11,218,771 (GRCm39)	R784W	probably damaging	Het
Lrriq1	T	C	10: 102,982,144 (GRCm39)	E1392G	probably damaging	Het
Muc19	T	C	15: 91,781,816 (GRCm39)		noncoding transcript	Het
Myom2	A	T	8: 15,164,237 (GRCm39)	D1044V	probably benign	Het
Nphp4	G	T	4: 152,639,988 (GRCm39)	R958L	probably damaging	Het
Nup205	C	T	6: 35,166,859 (GRCm39)	P293S	probably damaging	Het
Or10ag60	T	C	2: 87,437,903 (GRCm39)	I57T	probably benign	Het
Or1e17	A	T	11: 73,831,651 (GRCm39)	H193L	probably benign	Het
Plxdc2	A	G	2: 16,674,409 (GRCm39)		probably benign	Het
Pwp2	T	C	10: 78,014,899 (GRCm39)	S362G	probably damaging	Het
Siglec1	G	T	2: 130,916,915 (GRCm39)	S1113R	possibly damaging	Het
Sirpa	A	G	2: 129,471,989 (GRCm39)	E472G	probably damaging	Het
Slc39a4	G	T	15: 76,498,403 (GRCm39)	L345M	probably damaging	Het
Snx27	C	T	3: 94,410,188 (GRCm39)	R496Q	probably damaging	Het
Stard9	A	G	2: 120,527,388 (GRCm39)	H1215R	possibly damaging	Het
Stau1	A	G	2: 166,792,768 (GRCm39)	Y371H	probably benign	Het
Sult2a1	A	C	7: 13,566,520 (GRCm39)	W152G	probably benign	Het
Tcf7	T	A	11: 52,144,797 (GRCm39)		probably benign	Het
Tfdp1	A	G	8: 13,419,546 (GRCm39)	N92D	possibly damaging	Het
Zfp13	C	T	17: 23,795,072 (GRCm39)	A493T	probably benign	Het

Other mutations in Syt16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00984:Syt16	APN	12	74,269,604 (GRCm39)	nonsense	probably null
IGL01287:Syt16	APN	12	74,313,513 (GRCm39)	missense	probably damaging	1.00
IGL01401:Syt16	APN	12	74,269,437 (GRCm39)	missense	possibly damaging	0.66
IGL01780:Syt16	APN	12	74,313,616 (GRCm39)	missense	probably benign	0.15
IGL02350:Syt16	APN	12	74,313,616 (GRCm39)	missense	probably benign	0.15
IGL02353:Syt16	APN	12	74,176,245 (GRCm39)	missense	probably damaging	1.00
IGL02357:Syt16	APN	12	74,313,616 (GRCm39)	missense	probably benign	0.15
IGL02360:Syt16	APN	12	74,176,245 (GRCm39)	missense	probably damaging	1.00
IGL02696:Syt16	APN	12	74,176,185 (GRCm39)	missense	possibly damaging	0.90
R0701:Syt16	UTSW	12	74,281,886 (GRCm39)	missense	probably benign	0.01
R1103:Syt16	UTSW	12	74,313,672 (GRCm39)	missense	probably damaging	1.00
R2002:Syt16	UTSW	12	74,281,977 (GRCm39)	missense	possibly damaging	0.77
R2079:Syt16	UTSW	12	74,285,073 (GRCm39)	missense	probably damaging	1.00
R2124:Syt16	UTSW	12	74,285,009 (GRCm39)	missense	probably damaging	1.00
R3806:Syt16	UTSW	12	74,276,172 (GRCm39)	missense	possibly damaging	0.93
R3807:Syt16	UTSW	12	74,276,172 (GRCm39)	missense	possibly damaging	0.93
R4887:Syt16	UTSW	12	74,176,160 (GRCm39)	missense	probably damaging	0.96
R4889:Syt16	UTSW	12	74,176,269 (GRCm39)	missense	probably damaging	0.98
R5153:Syt16	UTSW	12	74,269,542 (GRCm39)	missense	possibly damaging	0.60
R6038:Syt16	UTSW	12	74,269,309 (GRCm39)	splice site	probably null
R6042:Syt16	UTSW	12	74,313,504 (GRCm39)	missense	probably damaging	1.00
R6328:Syt16	UTSW	12	74,313,467 (GRCm39)	nonsense	probably null
R6752:Syt16	UTSW	12	74,275,987 (GRCm39)	critical splice acceptor site	probably null
R7248:Syt16	UTSW	12	74,313,483 (GRCm39)	missense	probably damaging	1.00
R7275:Syt16	UTSW	12	74,313,483 (GRCm39)	missense	probably damaging	1.00
R7276:Syt16	UTSW	12	74,313,483 (GRCm39)	missense	probably damaging	1.00
R9058:Syt16	UTSW	12	74,282,019 (GRCm39)	missense	probably damaging	0.99
Z1177:Syt16	UTSW	12	74,269,563 (GRCm39)	missense	possibly damaging	0.92

Posted On

2015-04-16