Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02555:Vmn2r103'

298459

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL02555

Quality Score

Status

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19811611 bp

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 549 (D549V)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

Predicted Effect

probably damaging
Transcript: ENSMUST00000172203
AA Change: D549V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: D549V

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010109I03Rik	G	T	15: 74,881,608		probably benign	Het
Actr1b	G	A	1: 36,701,747	R199C	probably damaging	Het
Adam9	T	C	8: 24,966,736	N661D	probably damaging	Het
Amy1	C	T	3: 113,564,892	E164K	probably benign	Het
Arid5b	A	C	10: 68,101,904	D221E	probably benign	Het
B3galt1	G	T	2: 68,118,561	V207F	probably benign	Het
Begain	A	G	12: 109,034,189	S219P	probably damaging	Het
Clip1	A	G	5: 123,621,794		probably null	Het
Cps1	A	G	1: 67,214,021	K1224R	probably benign	Het
Dnm1	A	G	2: 32,328,038	Y449H	probably damaging	Het
Epas1	A	T	17: 86,829,064	M755L	probably benign	Het
F13b	T	C	1: 139,517,186	C525R	probably damaging	Het
Fmnl2	A	G	2: 53,126,851		probably null	Het
Gm5346	A	T	8: 43,625,268	C640S	probably damaging	Het
Ighv5-15	A	G	12: 113,827,115	F3L	probably benign	Het
Inpp4a	A	G	1: 37,379,968	Q538R	possibly damaging	Het
Insrr	A	T	3: 87,813,817	M1092L	probably damaging	Het
Itgb8	C	T	12: 119,189,881	V300M	probably damaging	Het
Kcnk5	A	T	14: 20,141,985	H369Q	probably benign	Het
Olfr1023	G	A	2: 85,887,398	M199I	probably benign	Het
Olfr1249	G	A	2: 89,630,203	R232C	probably damaging	Het
Olfr1294	A	G	2: 111,537,917	V124A	probably damaging	Het
Olfr24	T	A	9: 18,755,473	H54L	probably benign	Het
Plxdc2	A	G	2: 16,729,341	I417M	probably benign	Het
Polr1a	G	A	6: 71,920,457	E186K	probably damaging	Het
Ppp3cb	A	T	14: 20,530,953	F134L	probably damaging	Het
Prox2	C	T	12: 85,095,260	W56*	probably null	Het
Scaf4	C	T	16: 90,250,305	A395T	unknown	Het
Sh3tc2	G	T	18: 61,990,237	A690S	probably damaging	Het
Slc34a1	T	C	13: 55,401,168	S144P	possibly damaging	Het
Slc6a6	C	T	6: 91,748,330		probably benign	Het
Tubgcp3	A	T	8: 12,639,595	M557K	probably benign	Het
Washc2	T	A	6: 116,209,100	N90K	probably damaging	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19812384	missense	probably benign	0.01
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Posted On

2015-04-16