Incidental Mutation 'IGL02556:Or11g2'
ID 298489
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or11g2
Ensembl Gene ENSMUSG00000053815
Gene Name olfactory receptor family 11 subfamily G member 2
Synonyms MOR106-13P, GA_x6K02T2PMLR-6326342-6327313, Olfr744
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # IGL02556
Quality Score
Status
Chromosome 14
Chromosomal Location 50855681-50856652 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 50856185 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 169 (Q169K)
Ref Sequence ENSEMBL: ENSMUSP00000148954 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066457] [ENSMUST00000213668] [ENSMUST00000216690]
AlphaFold Q7TRM0
Predicted Effect probably benign
Transcript: ENSMUST00000066457
AA Change: Q169K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000066496
Gene: ENSMUSG00000053815
AA Change: Q169K

DomainStartEndE-ValueType
Pfam:7tm_4 35 312 2.9e-48 PFAM
Pfam:7tm_1 45 294 1.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213668
AA Change: Q169K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Predicted Effect probably benign
Transcript: ENSMUST00000216690
AA Change: Q169K

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik T G 10: 100,446,579 (GRCm39) probably null Het
Ace A G 11: 105,863,353 (GRCm39) D376G probably damaging Het
Adgrb1 C T 15: 74,458,654 (GRCm39) T1252I probably damaging Het
Bhmt T C 13: 93,774,008 (GRCm39) probably benign Het
Ckap5 T C 2: 91,425,186 (GRCm39) probably benign Het
Clcn4 T C 7: 7,299,065 (GRCm39) T37A probably benign Het
Cnmd C T 14: 79,899,400 (GRCm39) V18I probably benign Het
Cryl1 C T 14: 57,513,478 (GRCm39) V248M probably benign Het
D830039M14Rik C T 10: 61,311,262 (GRCm39) probably benign Het
Dido1 T C 2: 180,331,128 (GRCm39) T107A possibly damaging Het
Efna5 C A 17: 62,958,023 (GRCm39) V78F probably damaging Het
Eml1 A G 12: 108,503,625 (GRCm39) I741V probably benign Het
Gfap A G 11: 102,787,780 (GRCm39) L55P probably damaging Het
Itga6 A G 2: 71,669,027 (GRCm39) I606V probably benign Het
Kif2c G T 4: 117,019,802 (GRCm39) D579E probably damaging Het
Lef1 T C 3: 130,988,442 (GRCm39) probably null Het
Lrrc1 T A 9: 77,342,404 (GRCm39) I357L probably benign Het
Lrrc37 A G 11: 103,504,109 (GRCm39) S2620P probably benign Het
Map3k20 T A 2: 72,202,239 (GRCm39) F157I probably damaging Het
Naga A T 15: 82,214,337 (GRCm39) N391K probably damaging Het
Ncaph T C 2: 126,968,025 (GRCm39) probably benign Het
Or12d13 T A 17: 37,647,887 (GRCm39) M79L probably benign Het
Or5ae1 T G 7: 84,565,567 (GRCm39) Y193* probably null Het
Or6b9 T A 7: 106,555,598 (GRCm39) I182F possibly damaging Het
Or6c2b T G 10: 128,947,904 (GRCm39) Y130S probably damaging Het
Or8g55 T A 9: 39,784,906 (GRCm39) C112S possibly damaging Het
Pappa C A 4: 65,074,863 (GRCm39) D472E possibly damaging Het
Pdxk G A 10: 78,287,319 (GRCm39) L81F probably damaging Het
Pkhd1 G T 1: 20,380,934 (GRCm39) T2635K probably damaging Het
Psmb6 A T 11: 70,417,248 (GRCm39) H99L possibly damaging Het
Ptpn6 C T 6: 124,705,623 (GRCm39) G135E probably benign Het
Ptprz1 T A 6: 22,972,844 (GRCm39) D251E probably benign Het
Ralgapa1 A G 12: 55,689,234 (GRCm39) V1955A possibly damaging Het
Rsph4a T C 10: 33,781,148 (GRCm39) probably benign Het
Sh2d4b T C 14: 40,542,700 (GRCm39) T359A probably benign Het
Sh3bp5l A G 11: 58,237,087 (GRCm39) D348G probably damaging Het
Skint5 A T 4: 113,797,932 (GRCm39) M217K probably damaging Het
Slc30a6 T C 17: 74,711,054 (GRCm39) L49P probably damaging Het
Slc8a1 C T 17: 81,956,173 (GRCm39) M288I probably benign Het
Tmem127 C A 2: 127,097,922 (GRCm39) probably null Het
Tnfrsf17 T C 16: 11,131,811 (GRCm39) probably benign Het
Trak1 A T 9: 121,277,967 (GRCm39) N341I probably damaging Het
Ubr5 A G 15: 38,002,692 (GRCm39) I1453T probably benign Het
Wdr62 T C 7: 29,944,709 (GRCm39) probably null Het
Xrn2 T C 2: 146,880,216 (GRCm39) probably benign Het
Zscan10 C T 17: 23,827,119 (GRCm39) A144V possibly damaging Het
Other mutations in Or11g2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01373:Or11g2 APN 14 50,856,069 (GRCm39) missense probably damaging 1.00
IGL02136:Or11g2 APN 14 50,855,708 (GRCm39) missense possibly damaging 0.86
IGL02165:Or11g2 APN 14 50,856,468 (GRCm39) missense probably damaging 1.00
IGL02207:Or11g2 APN 14 50,856,015 (GRCm39) missense probably damaging 1.00
IGL02710:Or11g2 APN 14 50,856,255 (GRCm39) missense probably benign 0.02
R0127:Or11g2 UTSW 14 50,855,789 (GRCm39) missense probably benign
R0389:Or11g2 UTSW 14 50,856,036 (GRCm39) missense probably damaging 1.00
R0603:Or11g2 UTSW 14 50,855,967 (GRCm39) missense probably damaging 1.00
R0927:Or11g2 UTSW 14 50,856,044 (GRCm39) missense possibly damaging 0.47
R1477:Or11g2 UTSW 14 50,856,170 (GRCm39) missense probably damaging 0.98
R1705:Or11g2 UTSW 14 50,856,579 (GRCm39) missense probably benign 0.01
R1800:Or11g2 UTSW 14 50,856,143 (GRCm39) missense probably benign 0.01
R1898:Or11g2 UTSW 14 50,856,231 (GRCm39) missense probably damaging 1.00
R2244:Or11g2 UTSW 14 50,856,114 (GRCm39) missense probably damaging 1.00
R4731:Or11g2 UTSW 14 50,856,026 (GRCm39) missense probably benign 0.11
R4732:Or11g2 UTSW 14 50,856,026 (GRCm39) missense probably benign 0.11
R4733:Or11g2 UTSW 14 50,856,026 (GRCm39) missense probably benign 0.11
R4801:Or11g2 UTSW 14 50,856,479 (GRCm39) missense probably benign 0.01
R4802:Or11g2 UTSW 14 50,856,479 (GRCm39) missense probably benign 0.01
R5068:Or11g2 UTSW 14 50,856,197 (GRCm39) missense probably damaging 1.00
R5069:Or11g2 UTSW 14 50,856,197 (GRCm39) missense probably damaging 1.00
R5070:Or11g2 UTSW 14 50,856,197 (GRCm39) missense probably damaging 1.00
R5070:Or11g2 UTSW 14 50,855,931 (GRCm39) missense probably benign 0.11
R5195:Or11g2 UTSW 14 50,856,243 (GRCm39) missense probably damaging 1.00
R6058:Or11g2 UTSW 14 50,856,158 (GRCm39) missense probably benign 0.03
R8246:Or11g2 UTSW 14 50,855,841 (GRCm39) missense probably benign
R8275:Or11g2 UTSW 14 50,855,868 (GRCm39) missense probably damaging 1.00
R9292:Or11g2 UTSW 14 50,856,513 (GRCm39) missense possibly damaging 0.94
Posted On 2015-04-16