Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02559:Vmn2r11'

298598

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r11

Ensembl Gene

ENSMUSG00000091450

Gene Name

vomeronasal 2, receptor 11

Synonyms

EG384219

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

IGL02559

Quality Score

Status

Chromosome

Chromosomal Location

109046873-109059452 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 109052180 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Proline at position 469 (Q469P)

Ref Sequence

ENSEMBL: ENSMUSP00000133218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164875]

AlphaFold

E9Q4X4

Predicted Effect

probably damaging
Transcript: ENSMUST00000164875
AA Change: Q469P

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: Q469P

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	167	475	1.6e-29	PFAM
Pfam:NCD3G	520	574	9.1e-19	PFAM
Pfam:7tm_3	607	842	4.6e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3bp	C	T	16: 56,687,070	Q1004*	probably null	Het
Bahcc1	A	G	11: 120,285,172	D1914G	probably damaging	Het
Bcl11b	A	T	12: 107,915,394		probably benign	Het
Cdc45	C	T	16: 18,798,729	M200I	probably benign	Het
Col24a1	A	T	3: 145,314,173	I102F	probably benign	Het
Col7a1	C	T	9: 108,973,216	R2063C	unknown	Het
Ddo	T	A	10: 40,647,521	L169Q	probably damaging	Het
Defb4	G	T	8: 19,201,297	C60F	probably damaging	Het
Dock9	A	T	14: 121,625,147		probably benign	Het
Dysf	A	T	6: 84,067,446		probably benign	Het
Fasn	G	A	11: 120,809,066	A2253V	possibly damaging	Het
Fbxw26	T	C	9: 109,722,164	D355G	probably benign	Het
Gak	C	T	5: 108,584,232	E797K	probably null	Het
Gm10654	T	C	8: 70,932,130		noncoding transcript	Het
Gnas	T	C	2: 174,341,936		probably benign	Het
Hdac3	A	G	18: 37,954,891	F8S	probably damaging	Het
Hist1h2bj	T	A	13: 22,043,363	V45E	possibly damaging	Het
Hrh4	T	C	18: 13,007,244		probably null	Het
Klhl1	A	G	14: 96,151,960	V586A	possibly damaging	Het
Lct	T	C	1: 128,294,266	N1512S	probably damaging	Het
Mmp28	G	T	11: 83,447,740	N128K	probably benign	Het
Mndal	T	C	1: 173,872,920	T162A	probably benign	Het
Myh3	A	G	11: 67,101,095	E1822G	possibly damaging	Het
Mylpf	A	G	7: 127,214,143	Y133C	probably damaging	Het
Nup210l	G	A	3: 90,159,953	A767T	probably benign	Het
Olfr1404	T	C	1: 173,216,521	V290A	probably damaging	Het
Olfr221	A	G	14: 52,036,007	Y35H	probably damaging	Het
Olfr666	T	A	7: 104,892,954	R225W	probably benign	Het
Paics	A	G	5: 76,964,604	I312V	possibly damaging	Het
Pkdrej	G	T	15: 85,817,848	Q1296K	probably benign	Het
Ppil2	T	C	16: 17,109,651	K26E	possibly damaging	Het
Rufy1	A	G	11: 50,420,483	F170L	probably damaging	Het
Shcbp1	T	A	8: 4,749,305	E93V	probably damaging	Het
Slamf1	T	A	1: 171,767,258	I11K	possibly damaging	Het
Slc5a5	C	T	8: 70,890,271	G215D	probably damaging	Het
Slco1a1	A	T	6: 141,921,788	V473D	probably benign	Het
Slit1	A	G	19: 41,721,085	V123A	probably benign	Het
Srgap2	A	C	1: 131,524,936		probably null	Het
Stk32c	T	C	7: 139,120,690	M208V	probably benign	Het
Syt15	T	C	14: 34,221,803	V103A	probably benign	Het
Tacc2	T	A	7: 130,759,267	L456Q	probably damaging	Het
Tanc1	A	G	2: 59,724,654		probably benign	Het
Tepsin	G	T	11: 120,096,905	D62E	probably benign	Het
Thap3	T	C	4: 151,983,687	D106G	probably benign	Het
Ttn	T	C	2: 76,786,217	D14818G	probably damaging	Het
Txndc2	T	C	17: 65,639,590	N39S	possibly damaging	Het
Ubxn11	A	G	4: 134,124,943	E200G	probably damaging	Het
Yipf2	T	C	9: 21,592,186	T22A	probably damaging	Het

Other mutations in Vmn2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00925:Vmn2r11	APN	5	109047019	missense	probably benign	0.00
IGL01677:Vmn2r11	APN	5	109053957	missense	possibly damaging	0.50
IGL02048:Vmn2r11	APN	5	109054792	missense	probably benign	0.00
IGL02879:Vmn2r11	APN	5	109053838	missense	possibly damaging	0.95
IGL03084:Vmn2r11	APN	5	109059343	missense	probably benign	0.00
IGL03163:Vmn2r11	APN	5	109053826	missense	probably benign	0.41
IGL03289:Vmn2r11	APN	5	109048922	splice site	probably benign
IGL03294:Vmn2r11	APN	5	109054069	missense	probably benign	0.22
R0233:Vmn2r11	UTSW	5	109054102	missense	probably benign	0.16
R0233:Vmn2r11	UTSW	5	109054102	missense	probably benign	0.16
R0421:Vmn2r11	UTSW	5	109059428	missense	probably benign	0.00
R0549:Vmn2r11	UTSW	5	109052097	missense	possibly damaging	0.80
R0628:Vmn2r11	UTSW	5	109047731	missense	possibly damaging	0.88
R1523:Vmn2r11	UTSW	5	109053841	missense	probably benign	0.25
R1660:Vmn2r11	UTSW	5	109053858	missense	possibly damaging	0.79
R1827:Vmn2r11	UTSW	5	109052072	missense	probably benign	0.01
R1913:Vmn2r11	UTSW	5	109054788	missense	probably benign
R2260:Vmn2r11	UTSW	5	109053791	nonsense	probably null
R2400:Vmn2r11	UTSW	5	109052062	missense	probably benign	0.03
R3933:Vmn2r11	UTSW	5	109053394	missense	probably damaging	0.97
R4091:Vmn2r11	UTSW	5	109054750	critical splice donor site	probably null
R4624:Vmn2r11	UTSW	5	109052235	missense	probably damaging	0.99
R4762:Vmn2r11	UTSW	5	109047570	missense	probably damaging	1.00
R5256:Vmn2r11	UTSW	5	109054792	missense	probably benign	0.26
R5370:Vmn2r11	UTSW	5	109047555	missense	probably damaging	1.00
R5419:Vmn2r11	UTSW	5	109059358	missense	possibly damaging	0.55
R5516:Vmn2r11	UTSW	5	109047166	missense	probably damaging	0.98
R5643:Vmn2r11	UTSW	5	109047003	missense	probably damaging	1.00
R5671:Vmn2r11	UTSW	5	109054906	missense	probably benign	0.03
R5679:Vmn2r11	UTSW	5	109054842	missense	probably benign	0.00
R5739:Vmn2r11	UTSW	5	109059248	critical splice donor site	probably null
R5746:Vmn2r11	UTSW	5	109053694	missense	probably benign	0.41
R5995:Vmn2r11	UTSW	5	109047055	missense	probably damaging	1.00
R6147:Vmn2r11	UTSW	5	109054834	missense	probably benign	0.04
R6220:Vmn2r11	UTSW	5	109053568	missense	probably benign	0.09
R6374:Vmn2r11	UTSW	5	109053813	missense	possibly damaging	0.65
R6491:Vmn2r11	UTSW	5	109048934	missense	possibly damaging	0.95
R6804:Vmn2r11	UTSW	5	109053484	missense	probably damaging	1.00
R6814:Vmn2r11	UTSW	5	109047110	missense	possibly damaging	0.81
R6872:Vmn2r11	UTSW	5	109047110	missense	possibly damaging	0.81
R7014:Vmn2r11	UTSW	5	109053423	missense	probably damaging	1.00
R7041:Vmn2r11	UTSW	5	109054950	missense	probably damaging	1.00
R7043:Vmn2r11	UTSW	5	109052232	missense	probably benign	0.00
R7050:Vmn2r11	UTSW	5	109054791	missense	probably benign	0.05
R7184:Vmn2r11	UTSW	5	109053415	missense	probably damaging	1.00
R7388:Vmn2r11	UTSW	5	109054876	missense	probably benign	0.05
R7477:Vmn2r11	UTSW	5	109059348	missense	possibly damaging	0.67
R7524:Vmn2r11	UTSW	5	109053982	missense	probably benign	0.01
R7682:Vmn2r11	UTSW	5	109047615	missense	probably benign	0.02
R7715:Vmn2r11	UTSW	5	109047441	missense	probably damaging	0.99
R7869:Vmn2r11	UTSW	5	109052120	missense	probably damaging	1.00
R8094:Vmn2r11	UTSW	5	109053760	missense	probably damaging	1.00
R8277:Vmn2r11	UTSW	5	109054967	missense	probably benign	0.00
R8506:Vmn2r11	UTSW	5	109059404	missense	probably benign	0.00
R8676:Vmn2r11	UTSW	5	109053760	missense	probably damaging	1.00
R8701:Vmn2r11	UTSW	5	109047690	missense	probably damaging	1.00
R8749:Vmn2r11	UTSW	5	109047453	missense	probably damaging	0.97
R9046:Vmn2r11	UTSW	5	109054984	missense	probably benign	0.00
R9138:Vmn2r11	UTSW	5	109054038	missense	probably damaging	1.00
R9267:Vmn2r11	UTSW	5	109052063	missense	possibly damaging	0.93
R9306:Vmn2r11	UTSW	5	109048965	missense	probably damaging	1.00
R9384:Vmn2r11	UTSW	5	109053400	missense	probably damaging	1.00
R9443:Vmn2r11	UTSW	5	109047293	nonsense	probably null
R9520:Vmn2r11	UTSW	5	109053589	missense	probably benign	0.35
R9596:Vmn2r11	UTSW	5	109053697	missense	possibly damaging	0.67
R9677:Vmn2r11	UTSW	5	109053466	missense

Posted On

2015-04-16