Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02559:Mndal'

298624

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mndal

Ensembl Gene

ENSMUSG00000090272

Gene Name

myeloid nuclear differentiation antigen like

Synonyms

Gm2785

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.118) question?

Stock #

IGL02559

Quality Score

Status

Chromosome

Chromosomal Location

173849126-173942491 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 173872920 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 162 (T162A)

Ref Sequence

ENSEMBL: ENSMUSP00000140539 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000111210] [ENSMUST00000186442] [ENSMUST00000188804] [ENSMUST00000190071] [ENSMUST00000190651]

AlphaFold

D0QMC3

Predicted Effect

unknown
Transcript: ENSMUST00000111210
AA Change: T162A

SMART Domains

Protein: ENSMUSP00000106841
Gene: ENSMUSG00000090272
AA Change: T162A

Domain	Start	End	E-Value	Type
PYRIN	5	83	3.71e-20	SMART
internal_repeat_1	152	166	2.38e-7	PROSPERO
low complexity region	170	200	N/A	INTRINSIC
internal_repeat_1	208	222	2.38e-7	PROSPERO
low complexity region	225	249	N/A	INTRINSIC
low complexity region	276	292	N/A	INTRINSIC
low complexity region	294	305	N/A	INTRINSIC
Pfam:HIN	311	479	3.4e-76	PFAM
low complexity region	497	507	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000186442
AA Change: T162A

PolyPhen 2 Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000140539
Gene: ENSMUSG00000090272
AA Change: T162A

Domain	Start	End	E-Value	Type
PYRIN	5	83	1.8e-24	SMART
internal_repeat_1	152	166	4.72e-7	PROSPERO
low complexity region	170	200	N/A	INTRINSIC
internal_repeat_1	208	222	4.72e-7	PROSPERO
low complexity region	225	237	N/A	INTRINSIC
low complexity region	239	250	N/A	INTRINSIC
Pfam:HIN	258	427	2.9e-83	PFAM
low complexity region	444	454	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000187636

Predicted Effect

unknown
Transcript: ENSMUST00000188804
AA Change: T162A

SMART Domains

Protein: ENSMUSP00000140610
Gene: ENSMUSG00000090272
AA Change: T162A

Domain	Start	End	E-Value	Type
PYRIN	5	83	3.71e-20	SMART
internal_repeat_1	152	166	2.38e-7	PROSPERO
low complexity region	170	200	N/A	INTRINSIC
internal_repeat_1	208	222	2.38e-7	PROSPERO
low complexity region	225	249	N/A	INTRINSIC
low complexity region	276	292	N/A	INTRINSIC
low complexity region	294	305	N/A	INTRINSIC
Pfam:HIN	311	480	4.3e-86	PFAM
low complexity region	497	507	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189474

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189501

Predicted Effect

unknown
Transcript: ENSMUST00000190071
AA Change: T31A

SMART Domains

Protein: ENSMUSP00000141055
Gene: ENSMUSG00000090272
AA Change: T31A

Domain	Start	End	E-Value	Type
internal_repeat_1	21	35	3.67e-8	PROSPERO
low complexity region	39	69	N/A	INTRINSIC
internal_repeat_1	77	91	3.67e-8	PROSPERO
low complexity region	94	106	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000190651

SMART Domains

Protein: ENSMUSP00000140191
Gene: ENSMUSG00000090272

Domain	Start	End	E-Value	Type
PYRIN	5	83	1.8e-24	SMART
low complexity region	170	182	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000191500

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abi3bp	C	T	16: 56,687,070	Q1004*	probably null	Het
Bahcc1	A	G	11: 120,285,172	D1914G	probably damaging	Het
Bcl11b	A	T	12: 107,915,394		probably benign	Het
Cdc45	C	T	16: 18,798,729	M200I	probably benign	Het
Col24a1	A	T	3: 145,314,173	I102F	probably benign	Het
Col7a1	C	T	9: 108,973,216	R2063C	unknown	Het
Ddo	T	A	10: 40,647,521	L169Q	probably damaging	Het
Defb4	G	T	8: 19,201,297	C60F	probably damaging	Het
Dock9	A	T	14: 121,625,147		probably benign	Het
Dysf	A	T	6: 84,067,446		probably benign	Het
Fasn	G	A	11: 120,809,066	A2253V	possibly damaging	Het
Fbxw26	T	C	9: 109,722,164	D355G	probably benign	Het
Gak	C	T	5: 108,584,232	E797K	probably null	Het
Gm10654	T	C	8: 70,932,130		noncoding transcript	Het
Gnas	T	C	2: 174,341,936		probably benign	Het
Hdac3	A	G	18: 37,954,891	F8S	probably damaging	Het
Hist1h2bj	T	A	13: 22,043,363	V45E	possibly damaging	Het
Hrh4	T	C	18: 13,007,244		probably null	Het
Klhl1	A	G	14: 96,151,960	V586A	possibly damaging	Het
Lct	T	C	1: 128,294,266	N1512S	probably damaging	Het
Mmp28	G	T	11: 83,447,740	N128K	probably benign	Het
Myh3	A	G	11: 67,101,095	E1822G	possibly damaging	Het
Mylpf	A	G	7: 127,214,143	Y133C	probably damaging	Het
Nup210l	G	A	3: 90,159,953	A767T	probably benign	Het
Olfr1404	T	C	1: 173,216,521	V290A	probably damaging	Het
Olfr221	A	G	14: 52,036,007	Y35H	probably damaging	Het
Olfr666	T	A	7: 104,892,954	R225W	probably benign	Het
Paics	A	G	5: 76,964,604	I312V	possibly damaging	Het
Pkdrej	G	T	15: 85,817,848	Q1296K	probably benign	Het
Ppil2	T	C	16: 17,109,651	K26E	possibly damaging	Het
Rufy1	A	G	11: 50,420,483	F170L	probably damaging	Het
Shcbp1	T	A	8: 4,749,305	E93V	probably damaging	Het
Slamf1	T	A	1: 171,767,258	I11K	possibly damaging	Het
Slc5a5	C	T	8: 70,890,271	G215D	probably damaging	Het
Slco1a1	A	T	6: 141,921,788	V473D	probably benign	Het
Slit1	A	G	19: 41,721,085	V123A	probably benign	Het
Srgap2	A	C	1: 131,524,936		probably null	Het
Stk32c	T	C	7: 139,120,690	M208V	probably benign	Het
Syt15	T	C	14: 34,221,803	V103A	probably benign	Het
Tacc2	T	A	7: 130,759,267	L456Q	probably damaging	Het
Tanc1	A	G	2: 59,724,654		probably benign	Het
Tepsin	G	T	11: 120,096,905	D62E	probably benign	Het
Thap3	T	C	4: 151,983,687	D106G	probably benign	Het
Ttn	T	C	2: 76,786,217	D14818G	probably damaging	Het
Txndc2	T	C	17: 65,639,590	N39S	possibly damaging	Het
Ubxn11	A	G	4: 134,124,943	E200G	probably damaging	Het
Vmn2r11	T	G	5: 109,052,180	Q469P	probably damaging	Het
Yipf2	T	C	9: 21,592,186	T22A	probably damaging	Het

Other mutations in Mndal

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01363:Mndal	APN	1	173857456	missense	possibly damaging	0.68
IGL02309:Mndal	APN	1	173874455	missense	probably damaging	0.98
IGL02637:Mndal	APN	1	173857437	missense	possibly damaging	0.63
LCD18:Mndal	UTSW	1	173880218	unclassified	probably benign
R0076:Mndal	UTSW	1	173874447	nonsense	probably null
R0123:Mndal	UTSW	1	173857513	splice site	probably benign
R0134:Mndal	UTSW	1	173857513	splice site	probably benign
R0225:Mndal	UTSW	1	173857513	splice site	probably benign
R0976:Mndal	UTSW	1	173862845	missense	possibly damaging	0.70
R1081:Mndal	UTSW	1	173860222	missense	probably benign	0.01
R1497:Mndal	UTSW	1	173872875	missense	probably benign	0.04
R1522:Mndal	UTSW	1	173871466	missense	possibly damaging	0.68
R1630:Mndal	UTSW	1	173874392	missense	possibly damaging	0.52
R1874:Mndal	UTSW	1	173860367	unclassified	probably benign
R4183:Mndal	UTSW	1	173875771	missense	possibly damaging	0.95
R4544:Mndal	UTSW	1	173875664	nonsense	probably null
R4545:Mndal	UTSW	1	173875664	nonsense	probably null
R4907:Mndal	UTSW	1	173862690	missense	probably damaging	0.99
R5066:Mndal	UTSW	1	173875663	missense	probably damaging	1.00
R5853:Mndal	UTSW	1	173862504	missense	probably damaging	0.98
R6208:Mndal	UTSW	1	173857422	missense	possibly damaging	0.84
R6395:Mndal	UTSW	1	173871433	missense	possibly damaging	0.73
R6923:Mndal	UTSW	1	173884698	splice site	probably null
R6933:Mndal	UTSW	1	173875683	missense	probably damaging	1.00
R7030:Mndal	UTSW	1	173875594	missense	probably damaging	1.00
R7327:Mndal	UTSW	1	173875619	missense	unknown
R7648:Mndal	UTSW	1	173857395	missense	probably benign	0.01
R8130:Mndal	UTSW	1	173871545	nonsense	probably null
R8514:Mndal	UTSW	1	173860192	missense	possibly damaging	0.84
R8697:Mndal	UTSW	1	173872992	nonsense	probably null
R9134:Mndal	UTSW	1	173871530	missense	unknown
R9257:Mndal	UTSW	1	173862708	missense	probably damaging	1.00
R9458:Mndal	UTSW	1	173860183	missense	probably damaging	1.00
Z1177:Mndal	UTSW	1	173874404	missense	unknown

Posted On

2015-04-16