Incidental Mutation 'IGL02561:Gsto2'
ID 298677
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gsto2
Ensembl Gene ENSMUSG00000025069
Gene Name glutathione S-transferase omega 2
Synonyms 4930425C18Rik, 1700020F09Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02561
Quality Score
Status
Chromosome 19
Chromosomal Location 47853973-47874763 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 47874629 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056159] [ENSMUST00000120645] [ENSMUST00000135016]
AlphaFold Q8K2Q2
Predicted Effect noncoding transcript
Transcript: ENSMUST00000026048
Predicted Effect probably benign
Transcript: ENSMUST00000056159
SMART Domains Protein: ENSMUSP00000052592
Gene: ENSMUSG00000025069

DomainStartEndE-ValueType
Pfam:GST_N 23 95 1.7e-9 PFAM
Pfam:Glutaredoxin 24 75 1.1e-7 PFAM
Pfam:GST_N_3 26 101 1.9e-21 PFAM
Pfam:GST_N_2 31 96 3.2e-14 PFAM
SCOP:d1eema1 104 242 3e-25 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120645
SMART Domains Protein: ENSMUSP00000113409
Gene: ENSMUSG00000025069

DomainStartEndE-ValueType
Pfam:GST_N 22 95 3.8e-14 PFAM
Pfam:Glutaredoxin 24 75 9e-8 PFAM
Pfam:GST_N_3 26 101 6.9e-22 PFAM
Pfam:GST_N_2 31 96 1.7e-14 PFAM
SCOP:d1eema1 104 242 3e-25 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000135016
SMART Domains Protein: ENSMUSP00000119680
Gene: ENSMUSG00000025069

DomainStartEndE-ValueType
Pfam:GST_N 23 95 3.4e-10 PFAM
Pfam:Glutaredoxin 24 75 4.4e-8 PFAM
Pfam:GST_N_3 26 101 4.2e-22 PFAM
Pfam:GST_N_2 31 96 6e-15 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg3 T A 5: 105,125,536 (GRCm39) Q49L probably benign Het
Aifm2 A G 10: 61,561,786 (GRCm39) D44G probably damaging Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cmya5 T C 13: 93,228,366 (GRCm39) T2241A probably benign Het
Cntn4 C T 6: 106,500,470 (GRCm39) P316S probably damaging Het
Ctnna2 G T 6: 77,822,563 (GRCm39) S13R probably benign Het
Cyb5a G A 18: 84,889,637 (GRCm39) G46D probably damaging Het
Daam1 T C 12: 71,993,290 (GRCm39) V353A unknown Het
Ddx6 C T 9: 44,545,465 (GRCm39) T417I probably damaging Het
Fcgbp C T 7: 27,800,599 (GRCm39) probably benign Het
Gdi2 T C 13: 3,598,954 (GRCm39) I46T possibly damaging Het
Gm3629 T C 14: 17,805,586 (GRCm39) probably benign Het
Grap2 A T 15: 80,532,049 (GRCm39) probably benign Het
Gtf2a1 A T 12: 91,542,527 (GRCm39) D57E possibly damaging Het
Hif1a A G 12: 73,988,980 (GRCm39) I622M possibly damaging Het
Hmcn1 T C 1: 150,685,477 (GRCm39) T328A probably benign Het
Ighv1-54 T C 12: 115,157,389 (GRCm39) K86R probably benign Het
Igkv4-55 C T 6: 69,584,360 (GRCm39) S84N probably damaging Het
Ilvbl T C 10: 78,412,978 (GRCm39) S167P probably benign Het
Kcnn2 A G 18: 45,725,259 (GRCm39) I252V possibly damaging Het
Lss T C 10: 76,376,264 (GRCm39) probably benign Het
Mlip C A 9: 77,088,633 (GRCm39) probably null Het
Ncbp1 C T 4: 46,159,711 (GRCm39) T408M possibly damaging Het
Notch4 A G 17: 34,787,134 (GRCm39) probably benign Het
Npepps A T 11: 97,120,675 (GRCm39) C528* probably null Het
Nxf2 T C X: 133,857,201 (GRCm39) T163A probably benign Het
Or4c119 T C 2: 88,987,485 (GRCm39) I11M possibly damaging Het
Phka1 A T X: 101,641,895 (GRCm39) probably benign Het
Ptpn13 T G 5: 103,710,157 (GRCm39) L1564R probably damaging Het
Robo3 A G 9: 37,338,387 (GRCm39) S343P possibly damaging Het
Smarca2 A G 19: 26,693,582 (GRCm39) D1262G possibly damaging Het
Spns1 C T 7: 125,972,941 (GRCm39) probably null Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Ttpal A G 2: 163,449,369 (GRCm39) T75A probably damaging Het
Usp34 A G 11: 23,301,652 (GRCm39) T359A probably benign Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Zic2 A T 14: 122,715,957 (GRCm39) K360* probably null Het
Other mutations in Gsto2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00161:Gsto2 APN 19 47,863,406 (GRCm39) missense probably damaging 1.00
IGL02820:Gsto2 APN 19 47,863,398 (GRCm39) missense probably damaging 1.00
IGL03141:Gsto2 APN 19 47,863,312 (GRCm39) missense probably damaging 1.00
R1343:Gsto2 UTSW 19 47,873,146 (GRCm39) splice site probably null
R4297:Gsto2 UTSW 19 47,864,935 (GRCm39) missense possibly damaging 0.49
R4427:Gsto2 UTSW 19 47,860,212 (GRCm39) missense possibly damaging 0.94
R4701:Gsto2 UTSW 19 47,873,095 (GRCm39) missense probably benign 0.02
R4762:Gsto2 UTSW 19 47,863,312 (GRCm39) missense probably damaging 1.00
R6765:Gsto2 UTSW 19 47,860,227 (GRCm39) nonsense probably null
R7903:Gsto2 UTSW 19 47,873,096 (GRCm39) missense possibly damaging 0.50
R8877:Gsto2 UTSW 19 47,873,176 (GRCm39) missense probably damaging 1.00
R8939:Gsto2 UTSW 19 47,873,203 (GRCm39) critical splice donor site probably null
R9344:Gsto2 UTSW 19 47,864,884 (GRCm39) missense probably benign 0.25
R9351:Gsto2 UTSW 19 47,874,608 (GRCm39) missense possibly damaging 0.95
R9477:Gsto2 UTSW 19 47,864,911 (GRCm39) missense probably benign 0.01
X0018:Gsto2 UTSW 19 47,863,340 (GRCm39) missense probably benign 0.12
X0067:Gsto2 UTSW 19 47,874,461 (GRCm39) missense probably benign
Posted On 2015-04-16