Incidental Mutation 'IGL02562:Olfr167'
ID 298701
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr167
Ensembl Gene ENSMUSG00000045341
Gene Name olfactory receptor 167
Synonyms MOR272-1, GA_x54KRFPKG5P-15963726-15962788
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.335) question?
Stock # IGL02562
Quality Score
Status
Chromosome 16
Chromosomal Location 19509558-19522266 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19514964 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 224 (I224N)
Ref Sequence ENSEMBL: ENSMUSP00000150102 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054606] [ENSMUST00000214315]
AlphaFold Q8VGJ5
Predicted Effect possibly damaging
Transcript: ENSMUST00000054606
AA Change: I224N

PolyPhen 2 Score 0.744 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000055344
Gene: ENSMUSG00000045341
AA Change: I224N

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 4.8e-46 PFAM
Pfam:7TM_GPCR_Srsx 33 295 1.2e-6 PFAM
Pfam:7tm_1 40 289 1.8e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214315
AA Change: I224N

PolyPhen 2 Score 0.744 (Sensitivity: 0.85; Specificity: 0.92)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217566
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl4 T C 3: 151,439,312 C33R probably damaging Het
Aifm3 A G 16: 17,506,262 N562S probably benign Het
Akap14 G A X: 37,163,788 T98M possibly damaging Het
Atp7b T G 8: 22,028,085 T234P probably benign Het
Atp8b1 T A 18: 64,581,986 Q65L probably benign Het
Bclaf3 T C X: 159,566,438 S600P probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Col4a5 A G X: 141,656,675 probably benign Het
Gigyf2 A G 1: 87,407,375 D120G probably benign Het
Gm20498 T C 12: 81,510,842 D63G probably damaging Het
Gm4953 A T 1: 159,168,507 noncoding transcript Het
Hip1r G T 5: 123,991,523 probably benign Het
Itga2 A G 13: 114,836,570 probably benign Het
Itga3 T C 11: 95,068,793 T85A probably benign Het
Loxl1 A G 9: 58,288,916 S607P probably damaging Het
March2 G A 17: 33,696,074 T182I probably damaging Het
Mbd1 T C 18: 74,276,922 S386P probably benign Het
Meis2 C A 2: 116,049,146 G231V probably damaging Het
Mum1 A G 10: 80,238,895 D438G probably damaging Het
Myo1h A G 5: 114,357,992 K774E probably benign Het
Olfr1044 T G 2: 86,171,040 Y259S probably damaging Het
Olfr385 T C 11: 73,589,411 N109S probably benign Het
Olfr610 G T 7: 103,506,216 C243* probably null Het
Olfr714 C A 7: 107,074,562 H245N probably benign Het
Pcm1 T A 8: 41,325,368 D1813E probably damaging Het
Pdcl2 A G 5: 76,319,191 Y52H probably damaging Het
Piezo1 T C 8: 122,496,763 T816A probably benign Het
Ptpn13 T G 5: 103,562,291 L1564R probably damaging Het
Slc7a2 T A 8: 40,915,020 M607K probably damaging Het
Snrpa T A 7: 27,191,698 K116M probably damaging Het
Spon1 A G 7: 114,036,761 S737G probably benign Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Sspo A G 6: 48,490,122 probably null Het
Tubb4a C A 17: 57,081,163 E288* probably null Het
Vmn2r87 A T 10: 130,478,644 C358S probably damaging Het
Other mutations in Olfr167
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01535:Olfr167 APN 16 19515478 missense probably benign 0.01
IGL02115:Olfr167 APN 16 19515103 missense probably damaging 1.00
BB008:Olfr167 UTSW 16 19515508 missense possibly damaging 0.94
BB018:Olfr167 UTSW 16 19515508 missense possibly damaging 0.94
R0366:Olfr167 UTSW 16 19514848 missense probably benign 0.13
R0673:Olfr167 UTSW 16 19515396 missense probably damaging 1.00
R1187:Olfr167 UTSW 16 19515046 missense probably benign 0.01
R1237:Olfr167 UTSW 16 19515625 missense probably benign 0.01
R1975:Olfr167 UTSW 16 19514836 missense probably damaging 0.99
R1977:Olfr167 UTSW 16 19514836 missense probably damaging 0.99
R1997:Olfr167 UTSW 16 19515042 missense probably damaging 1.00
R2225:Olfr167 UTSW 16 19515246 missense probably benign 0.05
R2226:Olfr167 UTSW 16 19515246 missense probably benign 0.05
R4078:Olfr167 UTSW 16 19515232 missense possibly damaging 0.76
R5019:Olfr167 UTSW 16 19515535 missense probably damaging 0.99
R5071:Olfr167 UTSW 16 19515027 missense probably benign 0.00
R5278:Olfr167 UTSW 16 19515378 nonsense probably null
R5415:Olfr167 UTSW 16 19515246 missense possibly damaging 0.94
R5744:Olfr167 UTSW 16 19515336 missense probably benign 0.00
R5991:Olfr167 UTSW 16 19514757 missense probably damaging 0.99
R6151:Olfr167 UTSW 16 19515531 missense probably damaging 1.00
R6540:Olfr167 UTSW 16 19514821 missense probably benign
R7014:Olfr167 UTSW 16 19515456 missense probably benign 0.20
R7145:Olfr167 UTSW 16 19514899 missense probably damaging 0.99
R7535:Olfr167 UTSW 16 19514794 missense probably damaging 1.00
R7677:Olfr167 UTSW 16 19514928 missense probably benign 0.42
R7715:Olfr167 UTSW 16 19514730 missense probably benign 0.00
R7931:Olfr167 UTSW 16 19515508 missense possibly damaging 0.94
R8137:Olfr167 UTSW 16 19515096 missense possibly damaging 0.89
R8671:Olfr167 UTSW 16 19515054 missense possibly damaging 0.63
Posted On 2015-04-16