Incidental Mutation 'IGL02566:Gpr84'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr84
Ensembl Gene ENSMUSG00000063234
Gene NameG protein-coupled receptor 84
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02566
Quality Score
Chromosomal Location103308235-103310612 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 103308723 bp
Amino Acid Change Aspartic acid to Glycine at position 309 (D309G)
Ref Sequence ENSEMBL: ENSMUSP00000078753 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079824]
Predicted Effect probably benign
Transcript: ENSMUST00000079824
AA Change: D309G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000078753
Gene: ENSMUSG00000063234
AA Change: D309G

Pfam:7TM_GPCR_Srx 28 175 5e-10 PFAM
Pfam:7TM_GPCR_Srsx 31 221 7.3e-8 PFAM
Pfam:7tm_1 37 370 7.1e-39 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231068
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced IL4 production in response to CD3 crosslinking. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624J02Rik C T 7: 118,752,832 A154V probably benign Het
Arl4d A G 11: 101,667,154 S169G probably damaging Het
Bbx A T 16: 50,223,240 probably benign Het
Blm A T 7: 80,474,196 M959K probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cyb5d1 T C 11: 69,393,768 N186S probably benign Het
Elk3 A G 10: 93,265,463 L142P probably damaging Het
Gk5 G A 9: 96,129,046 D70N possibly damaging Het
Gm11492 T G 11: 87,567,642 S281A probably benign Het
Greb1l T C 18: 10,503,299 V450A probably damaging Het
Gucy1b1 A G 3: 82,058,329 F70S probably damaging Het
Jmjd4 T A 11: 59,455,054 M320K probably damaging Het
Map10 A G 8: 125,671,755 N629S probably benign Het
Nmd3 G T 3: 69,739,914 probably benign Het
Obscn G T 11: 59,068,147 T3359K probably damaging Het
Olfr31 C A 14: 14,328,138 T9K probably benign Het
Pkhd1l1 A G 15: 44,526,054 probably null Het
Plcb1 T C 2: 135,472,263 F1212L probably benign Het
Rabep1 A G 11: 70,917,714 S459G probably damaging Het
Slc26a1 A G 5: 108,673,799 S75P probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Sult1d1 A T 5: 87,564,811 L58Q probably damaging Het
Tnrc18 A T 5: 142,772,313 probably benign Het
Zfp442 T C 2: 150,409,791 probably null Het
Other mutations in Gpr84
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00479:Gpr84 APN 15 103309407 missense probably damaging 1.00
IGL02943:Gpr84 APN 15 103308889 missense probably benign 0.06
R1301:Gpr84 UTSW 15 103309219 missense probably damaging 0.98
R1762:Gpr84 UTSW 15 103309327 missense probably damaging 1.00
R4762:Gpr84 UTSW 15 103308600 missense probably damaging 1.00
R6362:Gpr84 UTSW 15 103308510 missense probably damaging 1.00
R6931:Gpr84 UTSW 15 103309014 missense probably damaging 0.99
Posted On2015-04-16