Incidental Mutation 'IGL02566:Gpr84'
| ID |
298818 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gpr84
|
| Ensembl Gene |
ENSMUSG00000063234 |
| Gene Name |
G protein-coupled receptor 84 |
| Synonyms |
EX33 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL02566
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
103216662-103219039 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 103217150 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 309
(D309G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078753
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079824]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079824
AA Change: D309G
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000078753
Gene: ENSMUSG00000063234
AA Change: D309G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7TM_GPCR_Srx
|
28 |
175 |
5e-10 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
31 |
221 |
7.3e-8 |
PFAM |
|
Pfam:7tm_1
|
37 |
370 |
7.1e-39 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000231068
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced IL4 production in response to CD3 crosslinking. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 24 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arl4d |
A |
G |
11: 101,557,980 (GRCm39) |
S169G |
probably damaging |
Het |
| Bbx |
A |
T |
16: 50,043,603 (GRCm39) |
|
probably benign |
Het |
| Blm |
A |
T |
7: 80,123,944 (GRCm39) |
M959K |
probably damaging |
Het |
| Cdc45 |
C |
T |
16: 18,617,479 (GRCm39) |
M200I |
probably benign |
Het |
| Cyb5d1 |
T |
C |
11: 69,284,594 (GRCm39) |
N186S |
probably benign |
Het |
| Elk3 |
A |
G |
10: 93,101,325 (GRCm39) |
L142P |
probably damaging |
Het |
| Gk5 |
G |
A |
9: 96,011,099 (GRCm39) |
D70N |
possibly damaging |
Het |
| Greb1l |
T |
C |
18: 10,503,299 (GRCm39) |
V450A |
probably damaging |
Het |
| Gucy1b1 |
A |
G |
3: 81,965,636 (GRCm39) |
F70S |
probably damaging |
Het |
| Jmjd4 |
T |
A |
11: 59,345,880 (GRCm39) |
M320K |
probably damaging |
Het |
| Map10 |
A |
G |
8: 126,398,494 (GRCm39) |
N629S |
probably benign |
Het |
| Nmd3 |
G |
T |
3: 69,647,247 (GRCm39) |
|
probably benign |
Het |
| Obscn |
G |
T |
11: 58,958,973 (GRCm39) |
T3359K |
probably damaging |
Het |
| Or2t1 |
C |
A |
14: 14,328,138 (GRCm38) |
T9K |
probably benign |
Het |
| Pkhd1l1 |
A |
G |
15: 44,389,450 (GRCm39) |
|
probably null |
Het |
| Plcb1 |
T |
C |
2: 135,314,183 (GRCm39) |
F1212L |
probably benign |
Het |
| Rabep1 |
A |
G |
11: 70,808,540 (GRCm39) |
S459G |
probably damaging |
Het |
| Septin4 |
T |
G |
11: 87,458,468 (GRCm39) |
S281A |
probably benign |
Het |
| Slc26a1 |
A |
G |
5: 108,821,665 (GRCm39) |
S75P |
probably damaging |
Het |
| Srrm1 |
G |
A |
4: 135,052,415 (GRCm39) |
P658L |
unknown |
Het |
| Sult1d1 |
A |
T |
5: 87,712,670 (GRCm39) |
L58Q |
probably damaging |
Het |
| Tnrc18 |
A |
T |
5: 142,758,068 (GRCm39) |
|
probably benign |
Het |
| Vps35l |
C |
T |
7: 118,352,055 (GRCm39) |
A154V |
probably benign |
Het |
| Zfp442 |
T |
C |
2: 150,251,711 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Gpr84 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00479:Gpr84
|
APN |
15 |
103,217,834 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02943:Gpr84
|
APN |
15 |
103,217,316 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1301:Gpr84
|
UTSW |
15 |
103,217,646 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1762:Gpr84
|
UTSW |
15 |
103,217,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4762:Gpr84
|
UTSW |
15 |
103,217,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6362:Gpr84
|
UTSW |
15 |
103,216,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6931:Gpr84
|
UTSW |
15 |
103,217,441 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8419:Gpr84
|
UTSW |
15 |
103,217,963 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8846:Gpr84
|
UTSW |
15 |
103,218,037 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8906:Gpr84
|
UTSW |
15 |
103,217,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2015-04-16 |
Incidental Mutation