Incidental Mutation 'IGL02566:Olfr31'
ID298830
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr31
Ensembl Gene ENSMUSG00000072707
Gene Nameolfactory receptor 31
SynonymsMOR274-1, GA_x6K02T2PLTE-6714644-6715597, MTPCR53
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.174) question?
Stock #IGL02566
Quality Score
Status
Chromosome14
Chromosomal Location14322828-14331791 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 14328138 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Lysine at position 9 (T9K)
Ref Sequence ENSEMBL: ENSMUSP00000149019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100872] [ENSMUST00000206009] [ENSMUST00000217035]
Predicted Effect probably benign
Transcript: ENSMUST00000100872
AA Change: T9K

PolyPhen 2 Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000098434
Gene: ENSMUSG00000072707
AA Change: T9K

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 5.7e-50 PFAM
Pfam:7tm_1 40 289 3.1e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206009
AA Change: T9K

PolyPhen 2 Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect probably benign
Transcript: ENSMUST00000217035
AA Change: T9K

PolyPhen 2 Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224991
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624J02Rik C T 7: 118,752,832 A154V probably benign Het
Arl4d A G 11: 101,667,154 S169G probably damaging Het
Bbx A T 16: 50,223,240 probably benign Het
Blm A T 7: 80,474,196 M959K probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cyb5d1 T C 11: 69,393,768 N186S probably benign Het
Elk3 A G 10: 93,265,463 L142P probably damaging Het
Gk5 G A 9: 96,129,046 D70N possibly damaging Het
Gm11492 T G 11: 87,567,642 S281A probably benign Het
Gpr84 T C 15: 103,308,723 D309G probably benign Het
Greb1l T C 18: 10,503,299 V450A probably damaging Het
Gucy1b1 A G 3: 82,058,329 F70S probably damaging Het
Jmjd4 T A 11: 59,455,054 M320K probably damaging Het
Map10 A G 8: 125,671,755 N629S probably benign Het
Nmd3 G T 3: 69,739,914 probably benign Het
Obscn G T 11: 59,068,147 T3359K probably damaging Het
Pkhd1l1 A G 15: 44,526,054 probably null Het
Plcb1 T C 2: 135,472,263 F1212L probably benign Het
Rabep1 A G 11: 70,917,714 S459G probably damaging Het
Slc26a1 A G 5: 108,673,799 S75P probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Sult1d1 A T 5: 87,564,811 L58Q probably damaging Het
Tnrc18 A T 5: 142,772,313 probably benign Het
Zfp442 T C 2: 150,409,791 probably null Het
Other mutations in Olfr31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02550:Olfr31 APN 14 14328423 missense possibly damaging 0.91
IGL02902:Olfr31 APN 14 14328789 missense probably benign
IGL03106:Olfr31 APN 14 14328851 missense probably damaging 0.97
IGL03214:Olfr31 APN 14 14328284 missense probably damaging 0.98
R0333:Olfr31 UTSW 14 14328498 missense probably damaging 1.00
R0828:Olfr31 UTSW 14 14328800 missense probably benign 0.00
R1231:Olfr31 UTSW 14 14328515 missense probably benign 0.00
R1725:Olfr31 UTSW 14 14328977 missense probably damaging 1.00
R1823:Olfr31 UTSW 14 14328774 missense probably damaging 1.00
R1824:Olfr31 UTSW 14 14328774 missense probably damaging 1.00
R2026:Olfr31 UTSW 14 14328891 missense probably benign 0.10
R3891:Olfr31 UTSW 14 14328114 start codon destroyed probably null 0.99
R4327:Olfr31 UTSW 14 14328193 missense probably damaging 1.00
R4328:Olfr31 UTSW 14 14328193 missense probably damaging 1.00
R4608:Olfr31 UTSW 14 14328887 missense probably benign 0.06
R4893:Olfr31 UTSW 14 14328852 missense probably damaging 1.00
R5197:Olfr31 UTSW 14 14328462 missense probably damaging 1.00
R5402:Olfr31 UTSW 14 14328878 missense probably damaging 1.00
R5787:Olfr31 UTSW 14 14328725 missense probably damaging 0.98
R5897:Olfr31 UTSW 14 14328120 missense probably benign 0.00
R7340:Olfr31 UTSW 14 14328401 missense possibly damaging 0.90
R7709:Olfr31 UTSW 14 14328384 missense probably damaging 1.00
R8284:Olfr31 UTSW 14 14329011 missense possibly damaging 0.91
Posted On2015-04-16