Incidental Mutation 'IGL02566:Sult1d1'
ID298832
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult1d1
Ensembl Gene ENSMUSG00000029273
Gene Namesulfotransferase family 1D, member 1
Synonymstyrosine-ester sulfotransferase, Sultn, 5033411P13Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.065) question?
Stock #IGL02566
Quality Score
Status
Chromosome5
Chromosomal Location87554645-87569027 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 87564811 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 58 (L58Q)
Ref Sequence ENSEMBL: ENSMUSP00000108940 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000113314]
PDB Structure
Crystal structure of mouse sulfotransferase SULT1D1 complex with PAP [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAP and p-nitrophenol [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAP and alpha-naphthol [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAPS [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAPS and p-nitrophenyl sulfate [X-RAY DIFFRACTION]
Crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAPS/PAP and p-nitrophenol [X-RAY DIFFRACTION]
crystal structure of mouse cytosolic sulfotransferase mSULT1D1 complex with PAP and p-nitrophenol, obtained by two-step soaking method [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000113314
AA Change: L58Q

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000108940
Gene: ENSMUSG00000029273
AA Change: L58Q

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 38 288 6e-95 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000166996
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased benzylic DNA adduct formation in the liver and kidney but increased formation in the colon. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9030624J02Rik C T 7: 118,752,832 A154V probably benign Het
Arl4d A G 11: 101,667,154 S169G probably damaging Het
Bbx A T 16: 50,223,240 probably benign Het
Blm A T 7: 80,474,196 M959K probably damaging Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cyb5d1 T C 11: 69,393,768 N186S probably benign Het
Elk3 A G 10: 93,265,463 L142P probably damaging Het
Gk5 G A 9: 96,129,046 D70N possibly damaging Het
Gm11492 T G 11: 87,567,642 S281A probably benign Het
Gpr84 T C 15: 103,308,723 D309G probably benign Het
Greb1l T C 18: 10,503,299 V450A probably damaging Het
Gucy1b1 A G 3: 82,058,329 F70S probably damaging Het
Jmjd4 T A 11: 59,455,054 M320K probably damaging Het
Map10 A G 8: 125,671,755 N629S probably benign Het
Nmd3 G T 3: 69,739,914 probably benign Het
Obscn G T 11: 59,068,147 T3359K probably damaging Het
Olfr31 C A 14: 14,328,138 T9K probably benign Het
Pkhd1l1 A G 15: 44,526,054 probably null Het
Plcb1 T C 2: 135,472,263 F1212L probably benign Het
Rabep1 A G 11: 70,917,714 S459G probably damaging Het
Slc26a1 A G 5: 108,673,799 S75P probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Tnrc18 A T 5: 142,772,313 probably benign Het
Zfp442 T C 2: 150,409,791 probably null Het
Other mutations in Sult1d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02306:Sult1d1 APN 5 87556055 splice site probably benign
IGL03080:Sult1d1 APN 5 87556988 missense probably benign 0.16
IGL03113:Sult1d1 APN 5 87559879 nonsense probably null
R0269:Sult1d1 UTSW 5 87564802 missense probably damaging 1.00
R1473:Sult1d1 UTSW 5 87564739 missense probably benign 0.13
R2105:Sult1d1 UTSW 5 87559802 missense probably damaging 1.00
R2273:Sult1d1 UTSW 5 87556028 missense probably damaging 1.00
R2919:Sult1d1 UTSW 5 87559755 splice site probably benign
R4416:Sult1d1 UTSW 5 87558576 missense probably damaging 1.00
R4648:Sult1d1 UTSW 5 87566095 missense probably benign 0.00
R5031:Sult1d1 UTSW 5 87559844 missense possibly damaging 0.77
R5108:Sult1d1 UTSW 5 87563869 critical splice donor site probably null
R5905:Sult1d1 UTSW 5 87559826 missense probably damaging 1.00
R5934:Sult1d1 UTSW 5 87559770 frame shift probably null
R6028:Sult1d1 UTSW 5 87559826 missense probably damaging 1.00
Posted On2015-04-16