Incidental Mutation 'IGL02567:Zfp142'
ID 298850
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp142
Ensembl Gene ENSMUSG00000026135
Gene Name zinc finger protein 142
Synonyms 9330177B18Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02567
Quality Score
Status
Chromosome 1
Chromosomal Location 74605490-74627308 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 74617309 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 341 (K341E)
Ref Sequence ENSEMBL: ENSMUSP00000027315 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027315] [ENSMUST00000066986] [ENSMUST00000113737] [ENSMUST00000127921] [ENSMUST00000156613]
AlphaFold G5E869
Predicted Effect possibly damaging
Transcript: ENSMUST00000027315
AA Change: K341E

PolyPhen 2 Score 0.923 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000027315
Gene: ENSMUSG00000026135
AA Change: K341E

DomainStartEndE-ValueType
ZnF_C2H2 103 127 1.16e1 SMART
ZnF_C2H2 164 186 1.26e-2 SMART
ZnF_C2H2 193 218 7.78e-3 SMART
ZnF_C2H2 223 247 2.29e0 SMART
ZnF_C2H2 250 272 9.96e-1 SMART
low complexity region 317 329 N/A INTRINSIC
ZnF_C2H2 363 385 9.96e-1 SMART
ZnF_C2H2 391 411 1.26e1 SMART
ZnF_C2H2 419 442 1.47e-3 SMART
ZnF_C2H2 453 475 2.75e-3 SMART
ZnF_C2H2 486 511 3.34e-2 SMART
ZnF_C2H2 516 540 4.81e0 SMART
ZnF_C2H2 543 566 7.05e-1 SMART
ZnF_C2H2 572 595 2.17e-1 SMART
ZnF_C2H2 601 623 1.56e-2 SMART
ZnF_C2H2 629 651 8.94e-3 SMART
ZnF_C2H2 657 679 1.38e-3 SMART
ZnF_C2H2 685 707 9.44e-2 SMART
ZnF_C2H2 712 735 1.26e-2 SMART
ZnF_C2H2 744 767 1.31e0 SMART
ZnF_C2H2 773 796 2.63e0 SMART
low complexity region 903 919 N/A INTRINSIC
low complexity region 953 969 N/A INTRINSIC
low complexity region 996 1007 N/A INTRINSIC
ZnF_C2H2 1039 1059 2.01e1 SMART
ZnF_C2H2 1069 1089 1.91e1 SMART
low complexity region 1147 1160 N/A INTRINSIC
ZnF_C2H2 1187 1207 2.7e2 SMART
low complexity region 1209 1222 N/A INTRINSIC
ZnF_C2H2 1265 1285 3.56e1 SMART
ZnF_C2H2 1295 1318 4.98e-1 SMART
ZnF_C2H2 1331 1354 2.49e-1 SMART
ZnF_C2H2 1360 1382 1.03e-2 SMART
ZnF_C2H2 1388 1411 5.72e-1 SMART
ZnF_C2H2 1417 1440 6.75e0 SMART
ZnF_C2H2 1446 1469 9.58e-3 SMART
ZnF_C2H2 1488 1511 1.64e-1 SMART
ZnF_C2H2 1514 1536 1.1e-2 SMART
ZnF_C2H2 1540 1563 4.05e-1 SMART
ZnF_C2H2 1580 1602 4.45e0 SMART
ZnF_C2H2 1608 1630 8.81e-2 SMART
ZnF_C2H2 1636 1658 1.18e-2 SMART
ZnF_C2H2 1664 1686 1.2e-3 SMART
ZnF_C2H2 1692 1715 3.89e-3 SMART
ZnF_C2H2 1721 1743 4.54e-4 SMART
ZnF_C2H2 1749 1771 1.18e-2 SMART
ZnF_C2H2 1777 1799 3.52e-1 SMART
low complexity region 1829 1838 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000066986
AA Change: K140E

PolyPhen 2 Score 0.676 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000065149
Gene: ENSMUSG00000026135
AA Change: K140E

DomainStartEndE-ValueType
low complexity region 116 128 N/A INTRINSIC
ZnF_C2H2 162 184 9.96e-1 SMART
ZnF_C2H2 190 210 1.26e1 SMART
ZnF_C2H2 218 241 1.47e-3 SMART
ZnF_C2H2 252 274 2.75e-3 SMART
ZnF_C2H2 285 310 3.34e-2 SMART
ZnF_C2H2 315 339 4.81e0 SMART
ZnF_C2H2 342 365 7.05e-1 SMART
ZnF_C2H2 371 394 2.17e-1 SMART
ZnF_C2H2 400 422 1.56e-2 SMART
ZnF_C2H2 428 450 8.94e-3 SMART
ZnF_C2H2 456 478 1.38e-3 SMART
ZnF_C2H2 484 506 9.44e-2 SMART
ZnF_C2H2 511 534 1.26e-2 SMART
ZnF_C2H2 543 566 1.31e0 SMART
ZnF_C2H2 572 595 2.63e0 SMART
low complexity region 702 718 N/A INTRINSIC
low complexity region 752 768 N/A INTRINSIC
low complexity region 795 806 N/A INTRINSIC
ZnF_C2H2 838 858 2.01e1 SMART
ZnF_C2H2 868 888 1.91e1 SMART
low complexity region 946 959 N/A INTRINSIC
ZnF_C2H2 986 1006 2.7e2 SMART
low complexity region 1008 1021 N/A INTRINSIC
ZnF_C2H2 1064 1084 3.56e1 SMART
ZnF_C2H2 1094 1117 4.98e-1 SMART
ZnF_C2H2 1130 1153 2.49e-1 SMART
ZnF_C2H2 1159 1181 1.03e-2 SMART
ZnF_C2H2 1187 1210 5.72e-1 SMART
ZnF_C2H2 1216 1239 6.75e0 SMART
ZnF_C2H2 1245 1268 9.58e-3 SMART
ZnF_C2H2 1287 1310 1.64e-1 SMART
ZnF_C2H2 1313 1335 1.1e-2 SMART
ZnF_C2H2 1339 1362 4.05e-1 SMART
ZnF_C2H2 1379 1401 4.45e0 SMART
ZnF_C2H2 1407 1429 8.81e-2 SMART
ZnF_C2H2 1435 1457 1.18e-2 SMART
ZnF_C2H2 1463 1485 1.2e-3 SMART
ZnF_C2H2 1491 1514 3.89e-3 SMART
ZnF_C2H2 1520 1542 4.54e-4 SMART
ZnF_C2H2 1548 1570 1.18e-2 SMART
ZnF_C2H2 1576 1598 3.52e-1 SMART
low complexity region 1628 1637 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000113737
AA Change: K238E

PolyPhen 2 Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000109366
Gene: ENSMUSG00000026135
AA Change: K238E

DomainStartEndE-ValueType
ZnF_C2H2 93 115 9.81e1 SMART
ZnF_C2H2 120 144 2.29e0 SMART
ZnF_C2H2 147 169 9.96e-1 SMART
low complexity region 214 226 N/A INTRINSIC
ZnF_C2H2 260 282 9.96e-1 SMART
ZnF_C2H2 288 308 1.26e1 SMART
ZnF_C2H2 316 339 1.47e-3 SMART
ZnF_C2H2 350 372 2.75e-3 SMART
ZnF_C2H2 383 408 3.34e-2 SMART
ZnF_C2H2 413 437 4.81e0 SMART
ZnF_C2H2 440 463 7.05e-1 SMART
ZnF_C2H2 469 492 2.17e-1 SMART
ZnF_C2H2 498 520 1.56e-2 SMART
ZnF_C2H2 526 548 8.94e-3 SMART
ZnF_C2H2 554 576 1.38e-3 SMART
ZnF_C2H2 582 604 9.44e-2 SMART
ZnF_C2H2 609 632 1.26e-2 SMART
ZnF_C2H2 641 664 1.31e0 SMART
ZnF_C2H2 670 693 2.63e0 SMART
low complexity region 800 816 N/A INTRINSIC
low complexity region 850 866 N/A INTRINSIC
low complexity region 893 904 N/A INTRINSIC
ZnF_C2H2 936 956 2.01e1 SMART
ZnF_C2H2 966 986 1.91e1 SMART
low complexity region 1044 1057 N/A INTRINSIC
ZnF_C2H2 1084 1104 2.7e2 SMART
low complexity region 1106 1119 N/A INTRINSIC
ZnF_C2H2 1162 1182 3.56e1 SMART
ZnF_C2H2 1192 1215 4.98e-1 SMART
ZnF_C2H2 1228 1251 2.49e-1 SMART
ZnF_C2H2 1257 1279 1.03e-2 SMART
ZnF_C2H2 1285 1308 5.72e-1 SMART
ZnF_C2H2 1314 1337 6.75e0 SMART
ZnF_C2H2 1343 1366 9.58e-3 SMART
ZnF_C2H2 1385 1408 1.64e-1 SMART
ZnF_C2H2 1411 1433 1.1e-2 SMART
ZnF_C2H2 1437 1460 4.05e-1 SMART
ZnF_C2H2 1477 1499 4.45e0 SMART
ZnF_C2H2 1505 1527 8.81e-2 SMART
ZnF_C2H2 1533 1555 1.18e-2 SMART
ZnF_C2H2 1561 1583 1.2e-3 SMART
ZnF_C2H2 1589 1612 3.89e-3 SMART
ZnF_C2H2 1618 1640 4.54e-4 SMART
ZnF_C2H2 1646 1668 1.18e-2 SMART
ZnF_C2H2 1674 1696 3.52e-1 SMART
low complexity region 1726 1735 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000127921
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130112
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136865
Predicted Effect unknown
Transcript: ENSMUST00000156613
AA Change: I181M
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff4 C A 11: 53,263,578 (GRCm39) S199R possibly damaging Het
Ano1 A G 7: 144,165,362 (GRCm39) L621P probably damaging Het
Calcr C T 6: 3,691,564 (GRCm39) V404M probably damaging Het
Carmil3 A G 14: 55,736,339 (GRCm39) S635G possibly damaging Het
Ccl12 C A 11: 81,993,447 (GRCm39) S28R possibly damaging Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cdhr3 T C 12: 33,088,900 (GRCm39) N761D probably benign Het
Col14a1 T C 15: 55,208,357 (GRCm39) probably null Het
Col28a1 T C 6: 8,014,819 (GRCm39) K862R possibly damaging Het
Cyp2c66 C T 19: 39,175,084 (GRCm39) probably benign Het
D5Ertd615e T C 5: 45,320,758 (GRCm39) noncoding transcript Het
Deup1 T C 9: 15,486,579 (GRCm39) E367G probably damaging Het
Dpp8 T G 9: 64,986,058 (GRCm39) Y849* probably null Het
Efhc1 T A 1: 21,043,188 (GRCm39) V369E probably damaging Het
Entrep2 T A 7: 64,436,479 (GRCm39) M101L possibly damaging Het
Epg5 A G 18: 78,076,288 (GRCm39) Y2562C probably damaging Het
Fbln5 A G 12: 101,728,059 (GRCm39) probably null Het
Frem1 A T 4: 82,918,292 (GRCm39) M551K probably damaging Het
Gba2 T C 4: 43,567,281 (GRCm39) S889G probably benign Het
Golph3 C T 15: 12,349,507 (GRCm39) R176* probably null Het
Got2 A T 8: 96,598,829 (GRCm39) F191Y probably benign Het
Gtf2ird2 G T 5: 134,241,890 (GRCm39) probably benign Het
H4c16 G A 6: 136,781,272 (GRCm39) R36W probably damaging Het
Hivep3 A G 4: 119,991,153 (GRCm39) T2218A probably damaging Het
Htr1f C T 16: 64,746,611 (GRCm39) G227D probably benign Het
Ifi202b C T 1: 173,791,370 (GRCm39) S436N possibly damaging Het
Nf1 T A 11: 79,437,969 (GRCm39) V2109D probably damaging Het
Opa1 C A 16: 29,407,104 (GRCm39) D29E probably benign Het
Papln C T 12: 83,825,611 (GRCm39) P631S probably benign Het
Pde4c T A 8: 71,200,570 (GRCm39) M352K probably benign Het
Pigu T C 2: 155,173,112 (GRCm39) T129A possibly damaging Het
Pla2g4c T A 7: 13,079,965 (GRCm39) H424Q probably damaging Het
Ptpn13 T G 5: 103,710,157 (GRCm39) L1564R probably damaging Het
Rbm5 T C 9: 107,621,473 (GRCm39) D642G probably damaging Het
Rnf111 T C 9: 70,366,287 (GRCm39) T384A probably damaging Het
Scn11a T C 9: 119,633,555 (GRCm39) T393A probably damaging Het
Sned1 A T 1: 93,202,069 (GRCm39) K619M probably damaging Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Syt9 A G 7: 107,035,868 (GRCm39) Y295C probably damaging Het
Taar7f T A 10: 23,926,323 (GRCm39) Y306N probably damaging Het
Tmem107 T G 11: 68,961,845 (GRCm39) L25V possibly damaging Het
Wdr24 T G 17: 26,043,322 (GRCm39) I48S probably damaging Het
Zc3hc1 T C 6: 30,374,848 (GRCm39) D231G probably benign Het
Zfp804b T A 5: 6,819,989 (GRCm39) I989L probably benign Het
Zfyve9 A C 4: 108,531,720 (GRCm39) V1095G probably damaging Het
Other mutations in Zfp142
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00581:Zfp142 APN 1 74,606,131 (GRCm39) missense probably damaging 1.00
IGL00711:Zfp142 APN 1 74,611,593 (GRCm39) missense probably damaging 1.00
IGL01391:Zfp142 APN 1 74,618,699 (GRCm39) missense probably damaging 1.00
IGL01808:Zfp142 APN 1 74,615,184 (GRCm39) missense probably damaging 1.00
IGL02074:Zfp142 APN 1 74,609,022 (GRCm39) missense probably damaging 0.97
IGL02134:Zfp142 APN 1 74,609,022 (GRCm39) missense probably damaging 0.97
IGL02567:Zfp142 APN 1 74,617,308 (GRCm39) missense possibly damaging 0.92
IGL02567:Zfp142 APN 1 74,617,306 (GRCm39) missense possibly damaging 0.84
IGL02669:Zfp142 APN 1 74,610,432 (GRCm39) missense probably benign 0.18
IGL02694:Zfp142 APN 1 74,609,307 (GRCm39) missense probably damaging 0.98
IGL02884:Zfp142 APN 1 74,611,142 (GRCm39) missense probably damaging 0.99
IGL03000:Zfp142 APN 1 74,612,777 (GRCm39) missense probably benign 0.01
IGL03080:Zfp142 APN 1 74,610,368 (GRCm39) missense probably benign 0.18
IGL03238:Zfp142 APN 1 74,615,437 (GRCm39) missense probably benign 0.37
IGL03277:Zfp142 APN 1 74,610,193 (GRCm39) missense probably damaging 1.00
PIT4402001:Zfp142 UTSW 1 74,618,687 (GRCm39) missense probably damaging 1.00
R0124:Zfp142 UTSW 1 74,607,782 (GRCm39) missense probably damaging 1.00
R0256:Zfp142 UTSW 1 74,617,317 (GRCm39) missense probably benign
R0267:Zfp142 UTSW 1 74,615,223 (GRCm39) missense probably benign 0.05
R0306:Zfp142 UTSW 1 74,609,341 (GRCm39) missense probably damaging 1.00
R0321:Zfp142 UTSW 1 74,608,873 (GRCm39) missense probably damaging 1.00
R0466:Zfp142 UTSW 1 74,624,570 (GRCm39) missense possibly damaging 0.95
R0513:Zfp142 UTSW 1 74,610,714 (GRCm39) missense probably damaging 1.00
R1084:Zfp142 UTSW 1 74,610,985 (GRCm39) missense probably benign
R1534:Zfp142 UTSW 1 74,611,247 (GRCm39) missense probably benign 0.00
R1548:Zfp142 UTSW 1 74,609,263 (GRCm39) missense probably damaging 1.00
R1623:Zfp142 UTSW 1 74,610,934 (GRCm39) missense possibly damaging 0.56
R1628:Zfp142 UTSW 1 74,611,047 (GRCm39) missense possibly damaging 0.94
R1710:Zfp142 UTSW 1 74,611,389 (GRCm39) missense probably damaging 1.00
R1722:Zfp142 UTSW 1 74,608,935 (GRCm39) missense probably damaging 1.00
R1770:Zfp142 UTSW 1 74,618,790 (GRCm39) missense probably damaging 0.99
R2042:Zfp142 UTSW 1 74,609,778 (GRCm39) missense probably benign 0.10
R2112:Zfp142 UTSW 1 74,612,795 (GRCm39) missense probably damaging 1.00
R2249:Zfp142 UTSW 1 74,606,191 (GRCm39) missense probably damaging 1.00
R4393:Zfp142 UTSW 1 74,611,219 (GRCm39) missense probably benign 0.00
R4700:Zfp142 UTSW 1 74,609,431 (GRCm39) missense probably damaging 1.00
R4750:Zfp142 UTSW 1 74,611,617 (GRCm39) missense probably damaging 1.00
R4763:Zfp142 UTSW 1 74,615,671 (GRCm39) missense probably damaging 1.00
R5208:Zfp142 UTSW 1 74,610,027 (GRCm39) missense probably benign 0.18
R5233:Zfp142 UTSW 1 74,624,608 (GRCm39) missense probably damaging 1.00
R5585:Zfp142 UTSW 1 74,617,404 (GRCm39) nonsense probably null
R6192:Zfp142 UTSW 1 74,609,667 (GRCm39) missense probably damaging 1.00
R6461:Zfp142 UTSW 1 74,606,344 (GRCm39) missense probably damaging 1.00
R6482:Zfp142 UTSW 1 74,609,376 (GRCm39) splice site probably null
R7320:Zfp142 UTSW 1 74,609,167 (GRCm39) nonsense probably null
R7438:Zfp142 UTSW 1 74,624,679 (GRCm39) missense probably benign
R7528:Zfp142 UTSW 1 74,610,061 (GRCm39) missense probably benign 0.00
R7600:Zfp142 UTSW 1 74,612,827 (GRCm39) missense probably damaging 1.00
R8007:Zfp142 UTSW 1 74,610,655 (GRCm39) missense probably benign 0.01
R8681:Zfp142 UTSW 1 74,610,747 (GRCm39) missense probably damaging 1.00
R8772:Zfp142 UTSW 1 74,610,825 (GRCm39) missense possibly damaging 0.87
R9058:Zfp142 UTSW 1 74,608,955 (GRCm39) nonsense probably null
R9233:Zfp142 UTSW 1 74,610,288 (GRCm39) missense probably benign
R9281:Zfp142 UTSW 1 74,607,731 (GRCm39) missense probably damaging 1.00
R9302:Zfp142 UTSW 1 74,606,302 (GRCm39) missense probably damaging 0.98
R9454:Zfp142 UTSW 1 74,609,016 (GRCm39) missense probably damaging 1.00
R9569:Zfp142 UTSW 1 74,615,386 (GRCm39) missense probably damaging 1.00
R9595:Zfp142 UTSW 1 74,611,462 (GRCm39) missense probably damaging 1.00
R9680:Zfp142 UTSW 1 74,610,933 (GRCm39) missense probably benign 0.16
Z1177:Zfp142 UTSW 1 74,609,325 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16