Incidental Mutation 'IGL02569:Olfr705'
ID298941
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr705
Ensembl Gene ENSMUSG00000109058
Gene Nameolfactory receptor 705
SynonymsGA_x6K02T2PBJ9-9256348-9255398, MOR283-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.208) question?
Stock #IGL02569
Quality Score
Status
Chromosome7
Chromosomal Location106871870-106876891 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 106714586 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Leucine at position 32 (I32L)
Ref Sequence ENSEMBL: ENSMUSP00000149773 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080925] [ENSMUST00000216868]
Predicted Effect probably benign
Transcript: ENSMUST00000080925
AA Change: I32L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000079726
Gene: ENSMUSG00000073900
AA Change: I32L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.1e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.5e-7 PFAM
Pfam:7tm_1 41 290 1.5e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216868
AA Change: I32L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830411N06Rik A C 7: 140,298,362 I885L probably benign Het
Abca1 T C 4: 53,034,061 D2223G probably damaging Het
Brd1 A G 15: 88,713,929 L538P probably damaging Het
Cacna2d2 T C 9: 107,514,046 V424A probably damaging Het
Capg A C 6: 72,561,049 E306A probably damaging Het
Cdc14b T C 13: 64,225,614 Y115C probably benign Het
Crat G A 2: 30,404,530 R509W probably damaging Het
Ddx60 A G 8: 62,024,951 N1594S possibly damaging Het
Fabp2 T C 3: 122,895,464 F18L probably damaging Het
Fam187a A G 11: 102,886,159 K263R probably benign Het
Fam227a C T 15: 79,634,122 C323Y probably benign Het
Fas A G 19: 34,320,562 E210G possibly damaging Het
Fgfbp1 A G 5: 43,979,227 F241S probably damaging Het
Gramd1a A T 7: 31,130,507 probably benign Het
Hmcn1 A T 1: 150,697,493 M2135K probably benign Het
Ikbkb G T 8: 22,693,883 Q84K probably damaging Het
Kcnk9 T C 15: 72,512,577 T251A probably benign Het
Mphosph9 C A 5: 124,297,571 E600* probably null Het
Olfr694 T A 7: 106,689,642 T30S probably benign Het
Pde1a C A 2: 79,868,258 K341N probably benign Het
Prune2 A G 19: 17,178,859 N2792S probably damaging Het
Slc17a3 A G 13: 23,846,302 Y132C probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
St6galnac1 T C 11: 116,767,702 D312G probably damaging Het
Tardbp A G 4: 148,619,182 probably null Het
Tex9 C T 9: 72,478,363 V8I probably damaging Het
Tpr T A 1: 150,425,631 probably benign Het
Ttll8 C T 15: 88,933,926 W182* probably null Het
Vmn2r61 G A 7: 42,276,646 G525E probably damaging Het
Zfp111 T C 7: 24,207,069 T2A possibly damaging Het
Other mutations in Olfr705
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01743:Olfr705 APN 7 106714334 missense possibly damaging 0.48
IGL02203:Olfr705 APN 7 106714630 missense probably benign 0.02
IGL02342:Olfr705 APN 7 106714025 missense probably benign 0.13
IGL02544:Olfr705 APN 7 106714535 missense probably benign 0.39
PIT4651001:Olfr705 UTSW 7 106873523 missense probably damaging 1.00
R0501:Olfr705 UTSW 7 106714603 missense probably benign 0.01
R0504:Olfr705 UTSW 7 106714701 splice site probably benign
R0536:Olfr705 UTSW 7 106714321 missense probably damaging 1.00
R0633:Olfr705 UTSW 7 106713977 missense probably benign 0.03
R0686:Olfr705 UTSW 7 106714378 missense probably damaging 0.98
R1225:Olfr705 UTSW 7 106714524 missense probably benign 0.22
R1725:Olfr705 UTSW 7 106714058 missense probably benign
R1864:Olfr705 UTSW 7 106713823 missense possibly damaging 0.87
R2065:Olfr705 UTSW 7 106714166 missense probably benign 0.12
R2068:Olfr705 UTSW 7 106714166 missense probably benign 0.12
R2081:Olfr705 UTSW 7 106714198 missense probably benign
R4135:Olfr705 UTSW 7 106714003 missense probably damaging 1.00
R5649:Olfr705 UTSW 7 106714166 missense possibly damaging 0.89
R5858:Olfr705 UTSW 7 106873768 missense probably benign 0.01
R6083:Olfr705 UTSW 7 106873582 missense probably damaging 0.98
R7144:Olfr705 UTSW 7 106873868 missense probably damaging 1.00
R7214:Olfr705 UTSW 7 106874267 start gained probably benign
R7366:Olfr705 UTSW 7 106873396 missense probably damaging 1.00
R7445:Olfr705 UTSW 7 106873342 missense possibly damaging 0.55
R8171:Olfr705 UTSW 7 106714618 missense probably benign
R8171:Olfr705 UTSW 7 106714619 missense
Posted On2015-04-16