Incidental Mutation 'IGL02571:Cyp4f17'
ID298997
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4f17
Ensembl Gene ENSMUSG00000091586
Gene Namecytochrome P450, family 4, subfamily f, polypeptide 17
SynonymsEG208285
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.061) question?
Stock #IGL02571
Quality Score
Status
Chromosome17
Chromosomal Location32506462-32528894 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 32524904 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 352 (E352G)
Ref Sequence ENSEMBL: ENSMUSP00000129514 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165999]
Predicted Effect probably benign
Transcript: ENSMUST00000165999
AA Change: E352G

PolyPhen 2 Score 0.418 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000129514
Gene: ENSMUSG00000091586
AA Change: E352G

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:p450 52 515 3.5e-135 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp8a2 T C 14: 60,012,458 probably benign Het
Cacna2d2 G A 9: 107,525,646 E885K possibly damaging Het
Dip2b T C 15: 100,157,885 W373R possibly damaging Het
Fam71b G T 11: 46,405,245 R148L probably damaging Het
Gem C A 4: 11,713,628 Q255K probably benign Het
Herc1 T C 9: 66,434,605 probably benign Het
Herc2 A T 7: 56,153,386 N2161I probably damaging Het
Ift172 A G 5: 31,257,891 F1325L probably damaging Het
Irgc1 T C 7: 24,432,591 K267R probably damaging Het
Kif1a A G 1: 93,020,456 probably null Het
Lifr G T 15: 7,190,111 probably benign Het
Mrpl12 A G 11: 120,485,432 probably null Het
Mrps18c A G 5: 100,801,975 D74G probably damaging Het
Mtus1 C T 8: 41,083,482 G399D possibly damaging Het
Nf1 T C 11: 79,428,627 I536T probably damaging Het
Olfr1441 C A 19: 12,422,886 S192R possibly damaging Het
Pcdh9 A G 14: 93,560,587 probably benign Het
Rnf123 G A 9: 108,068,302 R390* probably null Het
Rubcnl A T 14: 75,032,136 Q78L possibly damaging Het
Sis C A 3: 72,956,304 probably benign Het
Tbc1d2 T C 4: 46,628,370 M320V probably benign Het
Vmn1r178 C T 7: 23,894,235 T236I probably damaging Het
Xpc T C 6: 91,504,071 D273G probably benign Het
Zfhx4 A C 3: 5,329,523 N1033T probably damaging Het
Zfp646 A G 7: 127,879,412 T254A probably damaging Het
Other mutations in Cyp4f17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00580:Cyp4f17 APN 17 32524875 nonsense probably null
IGL01767:Cyp4f17 APN 17 32506982 missense probably benign
IGL01867:Cyp4f17 APN 17 32528083 missense probably benign 0.30
IGL02009:Cyp4f17 APN 17 32524880 missense probably damaging 1.00
IGL02423:Cyp4f17 APN 17 32506949 missense possibly damaging 0.93
IGL02503:Cyp4f17 APN 17 32524966 critical splice donor site probably null
IGL03328:Cyp4f17 APN 17 32520626 missense probably damaging 1.00
IGL03047:Cyp4f17 UTSW 17 32524049 missense possibly damaging 0.88
PIT4810001:Cyp4f17 UTSW 17 32524600 missense possibly damaging 0.56
R0486:Cyp4f17 UTSW 17 32524823 splice site probably benign
R0606:Cyp4f17 UTSW 17 32527843 missense probably damaging 0.98
R0655:Cyp4f17 UTSW 17 32524897 missense possibly damaging 0.95
R1781:Cyp4f17 UTSW 17 32524019 missense possibly damaging 0.94
R1795:Cyp4f17 UTSW 17 32517969 missense probably benign 0.00
R1833:Cyp4f17 UTSW 17 32524210 missense probably benign 0.01
R2268:Cyp4f17 UTSW 17 32517954 missense probably benign 0.44
R3030:Cyp4f17 UTSW 17 32506976 missense possibly damaging 0.93
R3861:Cyp4f17 UTSW 17 32528104 missense probably damaging 0.97
R5236:Cyp4f17 UTSW 17 32520632 critical splice donor site probably null
R5450:Cyp4f17 UTSW 17 32528886 missense probably benign
R5866:Cyp4f17 UTSW 17 32506913 missense probably benign 0.03
R5886:Cyp4f17 UTSW 17 32524039 missense possibly damaging 0.78
R5965:Cyp4f17 UTSW 17 32524637 missense probably damaging 0.99
R6692:Cyp4f17 UTSW 17 32506976 missense possibly damaging 0.93
R7056:Cyp4f17 UTSW 17 32527872 missense possibly damaging 0.94
R7968:Cyp4f17 UTSW 17 32524142 missense possibly damaging 0.87
R8458:Cyp4f17 UTSW 17 32520576 missense probably damaging 1.00
Posted On2015-04-16