Incidental Mutation 'IGL02574:Chid1'
| ID |
299147 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Chid1
|
| Ensembl Gene |
ENSMUSG00000025512 |
| Gene Name |
chitinase domain containing 1 |
| Synonyms |
3110023E09Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.072)
|
| Stock # |
IGL02574
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
141073049-141119770 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to T
at 141076603 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000147938
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026585]
[ENSMUST00000026586]
[ENSMUST00000117634]
[ENSMUST00000118694]
[ENSMUST00000138092]
[ENSMUST00000209452]
[ENSMUST00000166082]
[ENSMUST00000153191]
[ENSMUST00000146305]
|
| AlphaFold |
Q922Q9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000026585
|
| SMART Domains |
Protein: ENSMUSP00000026585
Gene: ENSMUSG00000025511
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tetraspannin
|
8 |
230 |
4.7e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000026586
|
| SMART Domains |
Protein: ENSMUSP00000026586
Gene: ENSMUSG00000025512
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:3BXW|A
|
4 |
240 |
1e-142 |
PDB |
|
Blast:Glyco_18
|
82 |
302 |
1e-139 |
BLAST |
|
SCOP:d1e9la1
|
84 |
240 |
1e-15 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000064642
|
| SMART Domains |
Protein: ENSMUSP00000065953
Gene: ENSMUSG00000025512
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:3BXW|A
|
3 |
236 |
1e-143 |
PDB |
|
Blast:Glyco_18
|
81 |
268 |
1e-121 |
BLAST |
|
SCOP:d1e9la1
|
83 |
236 |
2e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117634
|
| SMART Domains |
Protein: ENSMUSP00000113085
Gene: ENSMUSG00000025511
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tetraspannin
|
8 |
230 |
1.1e-53 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118694
|
| SMART Domains |
Protein: ENSMUSP00000112891
Gene: ENSMUSG00000025512
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:3BXW|A
|
1 |
237 |
1e-142 |
PDB |
|
Blast:Glyco_18
|
79 |
299 |
1e-139 |
BLAST |
|
SCOP:d1e9la1
|
81 |
237 |
1e-15 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130402
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000138092
|
| SMART Domains |
Protein: ENSMUSP00000115421
Gene: ENSMUSG00000025511
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tetraspannin
|
8 |
154 |
1.8e-38 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209452
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000147610
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166082
|
| SMART Domains |
Protein: ENSMUSP00000130360
Gene: ENSMUSG00000025512
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
25 |
35 |
N/A |
INTRINSIC |
|
Glyco_18
|
82 |
388 |
3.54e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153191
|
| SMART Domains |
Protein: ENSMUSP00000114693
Gene: ENSMUSG00000025512
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
22 |
32 |
N/A |
INTRINSIC |
|
Glyco_18
|
79 |
385 |
3.54e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146305
|
| SMART Domains |
Protein: ENSMUSP00000118533
Gene: ENSMUSG00000025511
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Tetraspannin
|
8 |
158 |
2.5e-41 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgef12 |
T |
C |
9: 42,916,919 (GRCm39) |
D409G |
probably damaging |
Het |
| AW551984 |
A |
C |
9: 39,500,382 (GRCm39) |
L792R |
possibly damaging |
Het |
| Cep192 |
A |
G |
18: 67,974,350 (GRCm39) |
E1151G |
probably damaging |
Het |
| Cfap44 |
C |
A |
16: 44,301,746 (GRCm39) |
P1828Q |
probably damaging |
Het |
| Col6a6 |
C |
A |
9: 105,659,390 (GRCm39) |
L518F |
probably damaging |
Het |
| Ctsz |
C |
T |
2: 174,270,891 (GRCm39) |
R201K |
probably benign |
Het |
| Diras1 |
T |
C |
10: 80,858,119 (GRCm39) |
Y44C |
probably damaging |
Het |
| Grip1 |
T |
C |
10: 119,778,818 (GRCm39) |
V159A |
probably damaging |
Het |
| Hpd |
T |
C |
5: 123,317,420 (GRCm39) |
|
probably benign |
Het |
| Jag2 |
T |
C |
12: 112,879,131 (GRCm39) |
N463S |
probably benign |
Het |
| Katnip |
A |
G |
7: 125,428,925 (GRCm39) |
T516A |
possibly damaging |
Het |
| Kmt2a |
C |
A |
9: 44,741,810 (GRCm39) |
|
probably benign |
Het |
| Myo5a |
A |
G |
9: 75,118,429 (GRCm39) |
N1619D |
probably benign |
Het |
| Ncbp1 |
A |
G |
4: 46,168,449 (GRCm39) |
|
probably null |
Het |
| Or12d13 |
G |
T |
17: 37,647,415 (GRCm39) |
A236E |
probably damaging |
Het |
| Or2n1b |
C |
T |
17: 38,460,280 (GRCm39) |
T267I |
possibly damaging |
Het |
| Pacsin2 |
G |
T |
15: 83,272,864 (GRCm39) |
A154E |
possibly damaging |
Het |
| Plcd4 |
A |
T |
1: 74,603,539 (GRCm39) |
I647F |
probably damaging |
Het |
| Prdm10 |
C |
T |
9: 31,268,589 (GRCm39) |
A846V |
probably damaging |
Het |
| Ptgs2 |
G |
T |
1: 149,978,526 (GRCm39) |
G213* |
probably null |
Het |
| Rcan3 |
C |
T |
4: 135,152,706 (GRCm39) |
S5N |
probably benign |
Het |
| Rnf123 |
G |
A |
9: 107,945,501 (GRCm39) |
R390* |
probably null |
Het |
| Serpinc1 |
A |
G |
1: 160,830,029 (GRCm39) |
N465S |
probably benign |
Het |
| Slc40a1 |
T |
C |
1: 45,951,534 (GRCm39) |
I208V |
possibly damaging |
Het |
| Vcl |
C |
T |
14: 20,979,643 (GRCm39) |
Q19* |
probably null |
Het |
|
| Other mutations in Chid1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00425:Chid1
|
APN |
7 |
141,102,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01095:Chid1
|
APN |
7 |
141,110,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Chid1
|
APN |
7 |
141,110,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01505:Chid1
|
APN |
7 |
141,093,807 (GRCm39) |
splice site |
probably null |
|
|
IGL02108:Chid1
|
APN |
7 |
141,112,841 (GRCm39) |
start codon destroyed |
probably null |
0.98 |
|
IGL02216:Chid1
|
APN |
7 |
141,076,506 (GRCm39) |
splice site |
probably benign |
|
|
R0006:Chid1
|
UTSW |
7 |
141,076,339 (GRCm39) |
splice site |
probably benign |
|
|
R0006:Chid1
|
UTSW |
7 |
141,076,339 (GRCm39) |
splice site |
probably benign |
|
|
R0711:Chid1
|
UTSW |
7 |
141,076,590 (GRCm39) |
missense |
probably benign |
|
|
R1518:Chid1
|
UTSW |
7 |
141,108,384 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1836:Chid1
|
UTSW |
7 |
141,106,409 (GRCm39) |
splice site |
probably null |
|
|
R5026:Chid1
|
UTSW |
7 |
141,093,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5516:Chid1
|
UTSW |
7 |
141,076,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5811:Chid1
|
UTSW |
7 |
141,110,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6009:Chid1
|
UTSW |
7 |
141,109,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Chid1
|
UTSW |
7 |
141,108,415 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6238:Chid1
|
UTSW |
7 |
141,076,049 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6966:Chid1
|
UTSW |
7 |
141,076,297 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7106:Chid1
|
UTSW |
7 |
141,102,573 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7278:Chid1
|
UTSW |
7 |
141,109,401 (GRCm39) |
splice site |
probably null |
|
|
R7773:Chid1
|
UTSW |
7 |
141,109,518 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8714:Chid1
|
UTSW |
7 |
141,093,678 (GRCm39) |
nonsense |
probably null |
|
|
R9169:Chid1
|
UTSW |
7 |
141,093,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9536:Chid1
|
UTSW |
7 |
141,093,755 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2015-04-16 |
Incidental Mutation