Incidental Mutation 'IGL02576:Prdm4'
ID 299194
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prdm4
Ensembl Gene ENSMUSG00000035529
Gene Name PR domain containing 4
Synonyms SC-1, SC1, 1700031E19Rik, 2810470D21Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02576
Quality Score
Status
Chromosome 10
Chromosomal Location 85727828-85752958 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85736801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 613 (M613T)
Ref Sequence ENSEMBL: ENSMUSP00000151931 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037646] [ENSMUST00000219370] [ENSMUST00000220032]
AlphaFold Q80V63
Predicted Effect possibly damaging
Transcript: ENSMUST00000037646
AA Change: M606T

PolyPhen 2 Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000041942
Gene: ENSMUSG00000035529
AA Change: M606T

DomainStartEndE-ValueType
low complexity region 14 28 N/A INTRINSIC
low complexity region 33 44 N/A INTRINSIC
low complexity region 51 69 N/A INTRINSIC
low complexity region 339 353 N/A INTRINSIC
PDB:3DB5|B 386 543 2e-98 PDB
Blast:SET 408 538 5e-82 BLAST
ZnF_C2H2 548 569 7.77e1 SMART
low complexity region 575 588 N/A INTRINSIC
ZnF_C2H2 593 615 3.78e-1 SMART
ZnF_C2H2 621 643 2.27e-4 SMART
ZnF_C2H2 649 671 8.02e-5 SMART
ZnF_C2H2 677 699 3.63e-3 SMART
ZnF_C2H2 705 727 3.11e-2 SMART
ZnF_C2H2 733 753 1.81e1 SMART
low complexity region 759 780 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218743
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219112
Predicted Effect probably benign
Transcript: ENSMUST00000219370
Predicted Effect possibly damaging
Transcript: ENSMUST00000220032
AA Change: M613T

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the PR/SET family of zinc finger proteins. This protein has been shown to bind DNA in a sequence-specific manner and has been implicated in neural stem cell proliferation and differentiation. Pseudogenes have been identified on chromosomes 14 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
PHENOTYPE: Mice homozygous for alleles lacking the zinc finger domain or PR/SET domain exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 A G 7: 120,032,678 (GRCm39) I232M probably benign Het
Ace G A 11: 105,864,937 (GRCm39) V537M probably damaging Het
Alg1 A G 16: 5,062,393 (GRCm39) E425G possibly damaging Het
Cacng3 G A 7: 122,271,133 (GRCm39) S46N probably benign Het
Cdc45 C T 16: 18,617,479 (GRCm39) M200I probably benign Het
Cfap65 A G 1: 74,942,617 (GRCm39) S1646P probably damaging Het
Cimap2 T C 4: 106,448,825 (GRCm39) D411G possibly damaging Het
Col20a1 C T 2: 180,655,198 (GRCm39) Q1152* probably null Het
D130043K22Rik A C 13: 25,040,853 (GRCm39) T92P possibly damaging Het
Drc3 T C 11: 60,261,377 (GRCm39) M176T probably benign Het
Esyt3 T C 9: 99,197,278 (GRCm39) R851G probably benign Het
Fbxo43 A G 15: 36,152,321 (GRCm39) V496A probably benign Het
Fut4 T A 9: 14,662,701 (GRCm39) M198L probably damaging Het
Galt C T 4: 41,755,953 (GRCm39) probably benign Het
Glipr1l1 A G 10: 111,896,224 (GRCm39) K4E possibly damaging Het
Gm9945 A G 11: 53,371,178 (GRCm39) probably benign Het
Hspa12a A C 19: 58,787,842 (GRCm39) I660R possibly damaging Het
Htr3b T C 9: 48,856,804 (GRCm39) I225V possibly damaging Het
Igf2r T C 17: 12,967,650 (GRCm39) D23G possibly damaging Het
Igsf5 A G 16: 96,187,781 (GRCm39) I158V probably benign Het
Itgae A G 11: 73,009,331 (GRCm39) Y505C possibly damaging Het
Kif16b A G 2: 142,704,465 (GRCm39) probably benign Het
Kif26b T C 1: 178,743,912 (GRCm39) V1336A probably benign Het
Kmt2d A G 15: 98,762,001 (GRCm39) S450P unknown Het
Lhfpl2 G A 13: 94,310,734 (GRCm39) M1I probably null Het
Lig4 A G 8: 10,021,116 (GRCm39) I888T probably damaging Het
Msh4 G A 3: 153,573,383 (GRCm39) T563M probably damaging Het
Muc5ac C T 7: 141,370,781 (GRCm39) A3238V probably benign Het
Myo15b A G 11: 115,780,879 (GRCm39) S1246G probably null Het
Or5h25 T C 16: 58,930,134 (GRCm39) I280V probably benign Het
Pecam1 G A 11: 106,562,600 (GRCm39) T599M probably damaging Het
Phf3 G A 1: 30,869,117 (GRCm39) P644S probably benign Het
Pkd1l1 A C 11: 8,794,560 (GRCm39) F2317C possibly damaging Het
Prim2 A T 1: 33,523,798 (GRCm39) I371N probably damaging Het
Ptprs T C 17: 56,721,958 (GRCm39) D1316G probably damaging Het
Rnf19b C T 4: 128,967,315 (GRCm39) R285* probably null Het
Secisbp2 A G 13: 51,824,894 (GRCm39) N381D possibly damaging Het
Slc28a2 T C 2: 122,288,652 (GRCm39) I586T probably damaging Het
Spef1 T C 2: 131,016,562 (GRCm39) H11R possibly damaging Het
Taar4 T C 10: 23,836,909 (GRCm39) L173S probably damaging Het
Tas2r123 T C 6: 132,824,703 (GRCm39) F200S possibly damaging Het
Tex16 T A X: 111,028,653 (GRCm39) L384Q probably benign Het
Tox2 A G 2: 163,118,100 (GRCm39) Q168R probably damaging Het
Trim5 T A 7: 103,927,624 (GRCm39) E172V probably damaging Het
Txndc11 G A 16: 10,892,881 (GRCm39) probably benign Het
Vmn1r232 T A 17: 21,134,175 (GRCm39) I142F probably benign Het
Zdhhc25 A T 15: 88,485,472 (GRCm39) H269L probably benign Het
Znrf4 T C 17: 56,819,199 (GRCm39) D36G probably damaging Het
Other mutations in Prdm4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01864:Prdm4 APN 10 85,729,100 (GRCm39) missense probably benign 0.08
IGL02514:Prdm4 APN 10 85,743,781 (GRCm39) missense probably damaging 0.99
IGL02674:Prdm4 APN 10 85,729,263 (GRCm39) missense probably damaging 0.99
IGL03002:Prdm4 APN 10 85,729,016 (GRCm39) missense probably benign 0.08
IGL03153:Prdm4 APN 10 85,743,860 (GRCm39) missense probably benign
IGL03278:Prdm4 APN 10 85,743,622 (GRCm39) missense probably damaging 0.99
IGL03338:Prdm4 APN 10 85,743,685 (GRCm39) missense possibly damaging 0.90
R0020:Prdm4 UTSW 10 85,743,487 (GRCm39) missense probably benign
R0133:Prdm4 UTSW 10 85,746,085 (GRCm39) critical splice donor site probably null
R0366:Prdm4 UTSW 10 85,743,868 (GRCm39) missense probably damaging 1.00
R0633:Prdm4 UTSW 10 85,743,767 (GRCm39) missense probably damaging 1.00
R1132:Prdm4 UTSW 10 85,735,145 (GRCm39) missense probably damaging 1.00
R1460:Prdm4 UTSW 10 85,743,686 (GRCm39) missense probably benign 0.28
R1477:Prdm4 UTSW 10 85,740,129 (GRCm39) missense probably benign 0.00
R1680:Prdm4 UTSW 10 85,735,087 (GRCm39) missense possibly damaging 0.96
R1772:Prdm4 UTSW 10 85,729,256 (GRCm39) missense probably damaging 0.99
R1983:Prdm4 UTSW 10 85,743,817 (GRCm39) missense probably damaging 1.00
R2136:Prdm4 UTSW 10 85,729,215 (GRCm39) nonsense probably null
R3426:Prdm4 UTSW 10 85,746,153 (GRCm39) missense probably damaging 1.00
R3723:Prdm4 UTSW 10 85,735,145 (GRCm39) missense probably damaging 1.00
R4490:Prdm4 UTSW 10 85,736,763 (GRCm39) missense probably damaging 1.00
R4750:Prdm4 UTSW 10 85,735,085 (GRCm39) missense probably damaging 1.00
R5561:Prdm4 UTSW 10 85,728,987 (GRCm39) makesense probably null
R5601:Prdm4 UTSW 10 85,728,987 (GRCm39) makesense probably null
R5602:Prdm4 UTSW 10 85,728,987 (GRCm39) makesense probably null
R5604:Prdm4 UTSW 10 85,728,987 (GRCm39) makesense probably null
R5972:Prdm4 UTSW 10 85,743,365 (GRCm39) missense probably damaging 1.00
R6272:Prdm4 UTSW 10 85,743,694 (GRCm39) missense possibly damaging 0.82
R6300:Prdm4 UTSW 10 85,746,085 (GRCm39) critical splice donor site probably null
R6457:Prdm4 UTSW 10 85,743,896 (GRCm39) missense probably damaging 1.00
R6605:Prdm4 UTSW 10 85,740,002 (GRCm39) missense probably benign 0.00
R6642:Prdm4 UTSW 10 85,743,682 (GRCm39) missense probably benign 0.00
R7663:Prdm4 UTSW 10 85,735,145 (GRCm39) missense probably damaging 1.00
R9064:Prdm4 UTSW 10 85,737,678 (GRCm39) missense probably damaging 0.98
R9071:Prdm4 UTSW 10 85,729,076 (GRCm39) missense probably benign
Posted On 2015-04-16