Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02576:Tex16'

299201

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex16

Ensembl Gene

ENSMUSG00000034555

Gene Name

testis expressed gene 16

Synonyms

4933403O08Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

IGL02576

Quality Score

Status

Chromosome

Chromosomal Location

110804655-111159053 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 111028653 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 384 (L384Q)

Ref Sequence

ENSEMBL: ENSMUSP00000118847 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038546] [ENSMUST00000130247] [ENSMUST00000207962]

AlphaFold

A2RT18

Predicted Effect

probably benign
Transcript: ENSMUST00000038546
AA Change: L373Q

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000048187
Gene: ENSMUSG00000034555
AA Change: L373Q

Domain	Start	End	E-Value	Type
low complexity region	1	12	N/A	INTRINSIC
low complexity region	110	122	N/A	INTRINSIC
low complexity region	616	669	N/A	INTRINSIC
low complexity region	674	699	N/A	INTRINSIC
low complexity region	811	824	N/A	INTRINSIC
low complexity region	833	850	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000130247
AA Change: L384Q

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000118847
Gene: ENSMUSG00000034555
AA Change: L384Q

Domain	Start	End	E-Value	Type
low complexity region	10	24	N/A	INTRINSIC
low complexity region	121	133	N/A	INTRINSIC
low complexity region	627	680	N/A	INTRINSIC
low complexity region	685	710	N/A	INTRINSIC
low complexity region	822	835	N/A	INTRINSIC
low complexity region	844	861	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000207962

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	A	G	7: 120,032,678 (GRCm39)	I232M	probably benign	Het
Ace	G	A	11: 105,864,937 (GRCm39)	V537M	probably damaging	Het
Alg1	A	G	16: 5,062,393 (GRCm39)	E425G	possibly damaging	Het
Cacng3	G	A	7: 122,271,133 (GRCm39)	S46N	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cfap65	A	G	1: 74,942,617 (GRCm39)	S1646P	probably damaging	Het
Cimap2	T	C	4: 106,448,825 (GRCm39)	D411G	possibly damaging	Het
Col20a1	C	T	2: 180,655,198 (GRCm39)	Q1152*	probably null	Het
D130043K22Rik	A	C	13: 25,040,853 (GRCm39)	T92P	possibly damaging	Het
Drc3	T	C	11: 60,261,377 (GRCm39)	M176T	probably benign	Het
Esyt3	T	C	9: 99,197,278 (GRCm39)	R851G	probably benign	Het
Fbxo43	A	G	15: 36,152,321 (GRCm39)	V496A	probably benign	Het
Fut4	T	A	9: 14,662,701 (GRCm39)	M198L	probably damaging	Het
Galt	C	T	4: 41,755,953 (GRCm39)		probably benign	Het
Glipr1l1	A	G	10: 111,896,224 (GRCm39)	K4E	possibly damaging	Het
Gm9945	A	G	11: 53,371,178 (GRCm39)		probably benign	Het
Hspa12a	A	C	19: 58,787,842 (GRCm39)	I660R	possibly damaging	Het
Htr3b	T	C	9: 48,856,804 (GRCm39)	I225V	possibly damaging	Het
Igf2r	T	C	17: 12,967,650 (GRCm39)	D23G	possibly damaging	Het
Igsf5	A	G	16: 96,187,781 (GRCm39)	I158V	probably benign	Het
Itgae	A	G	11: 73,009,331 (GRCm39)	Y505C	possibly damaging	Het
Kif16b	A	G	2: 142,704,465 (GRCm39)		probably benign	Het
Kif26b	T	C	1: 178,743,912 (GRCm39)	V1336A	probably benign	Het
Kmt2d	A	G	15: 98,762,001 (GRCm39)	S450P	unknown	Het
Lhfpl2	G	A	13: 94,310,734 (GRCm39)	M1I	probably null	Het
Lig4	A	G	8: 10,021,116 (GRCm39)	I888T	probably damaging	Het
Msh4	G	A	3: 153,573,383 (GRCm39)	T563M	probably damaging	Het
Muc5ac	C	T	7: 141,370,781 (GRCm39)	A3238V	probably benign	Het
Myo15b	A	G	11: 115,780,879 (GRCm39)	S1246G	probably null	Het
Or5h25	T	C	16: 58,930,134 (GRCm39)	I280V	probably benign	Het
Pecam1	G	A	11: 106,562,600 (GRCm39)	T599M	probably damaging	Het
Phf3	G	A	1: 30,869,117 (GRCm39)	P644S	probably benign	Het
Pkd1l1	A	C	11: 8,794,560 (GRCm39)	F2317C	possibly damaging	Het
Prdm4	A	G	10: 85,736,801 (GRCm39)	M613T	possibly damaging	Het
Prim2	A	T	1: 33,523,798 (GRCm39)	I371N	probably damaging	Het
Ptprs	T	C	17: 56,721,958 (GRCm39)	D1316G	probably damaging	Het
Rnf19b	C	T	4: 128,967,315 (GRCm39)	R285*	probably null	Het
Secisbp2	A	G	13: 51,824,894 (GRCm39)	N381D	possibly damaging	Het
Slc28a2	T	C	2: 122,288,652 (GRCm39)	I586T	probably damaging	Het
Spef1	T	C	2: 131,016,562 (GRCm39)	H11R	possibly damaging	Het
Taar4	T	C	10: 23,836,909 (GRCm39)	L173S	probably damaging	Het
Tas2r123	T	C	6: 132,824,703 (GRCm39)	F200S	possibly damaging	Het
Tox2	A	G	2: 163,118,100 (GRCm39)	Q168R	probably damaging	Het
Trim5	T	A	7: 103,927,624 (GRCm39)	E172V	probably damaging	Het
Txndc11	G	A	16: 10,892,881 (GRCm39)		probably benign	Het
Vmn1r232	T	A	17: 21,134,175 (GRCm39)	I142F	probably benign	Het
Zdhhc25	A	T	15: 88,485,472 (GRCm39)	H269L	probably benign	Het
Znrf4	T	C	17: 56,819,199 (GRCm39)	D36G	probably damaging	Het

Other mutations in Tex16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01712:Tex16	APN	X	111,003,451 (GRCm39)	missense	probably damaging	1.00
IGL03261:Tex16	APN	X	111,028,552 (GRCm39)	missense	possibly damaging	0.90
R1766:Tex16	UTSW	X	111,150,782 (GRCm39)	missense	probably benign	0.02
R2274:Tex16	UTSW	X	111,030,838 (GRCm39)	missense	probably damaging	0.98
R3607:Tex16	UTSW	X	111,003,667 (GRCm39)	missense	probably damaging	1.00
R3794:Tex16	UTSW	X	111,150,375 (GRCm39)	start codon destroyed	probably null	0.27
R4209:Tex16	UTSW	X	111,030,640 (GRCm39)	missense	probably benign	0.01
R4210:Tex16	UTSW	X	111,030,640 (GRCm39)	missense	probably benign	0.01
U24488:Tex16	UTSW	X	111,028,815 (GRCm39)	missense	probably benign	0.05
Z1176:Tex16	UTSW	X	111,151,010 (GRCm39)	missense	probably benign	0.36

Posted On

2015-04-16