Incidental Mutation 'IGL02578:Cyp4a32'
ID299243
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4a32
Ensembl Gene ENSMUSG00000063929
Gene Namecytochrome P450, family 4, subfamily a, polypeptide 32
SynonymsOTTMUSG00000008689
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.089) question?
Stock #IGL02578
Quality Score
Status
Chromosome4
Chromosomal Location115600969-115621602 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 115609742 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Arginine at position 208 (Q208R)
Ref Sequence ENSEMBL: ENSMUSP00000081369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084342]
Predicted Effect possibly damaging
Transcript: ENSMUST00000084342
AA Change: Q208R

PolyPhen 2 Score 0.787 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000081369
Gene: ENSMUSG00000063929
AA Change: Q208R

DomainStartEndE-ValueType
transmembrane domain 15 32 N/A INTRINSIC
Pfam:p450 51 504 1.3e-133 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129918
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 G A 7: 120,423,956 probably null Het
Ago1 T A 4: 126,439,531 D545V probably benign Het
Arid2 T C 15: 96,372,235 S1410P probably benign Het
Cbfa2t3 T A 8: 122,633,448 D488V possibly damaging Het
Cdx2 T C 5: 147,303,284 D194G probably damaging Het
Degs1 A C 1: 182,279,027 Y222* probably null Het
Dnah7a T A 1: 53,432,915 E3564D probably benign Het
Dsg4 A T 18: 20,471,193 I906F possibly damaging Het
Elovl3 A G 19: 46,134,693 H236R possibly damaging Het
Fam159a C T 4: 108,368,028 M112I probably benign Het
Foxp2 A G 6: 15,376,815 probably benign Het
Gm9892 A T 8: 52,196,293 noncoding transcript Het
Herc2 A G 7: 56,106,535 probably null Het
Hhat A G 1: 192,693,913 V304A probably damaging Het
Il16 C T 7: 83,677,986 probably null Het
Kansl1l G A 1: 66,801,689 Q151* probably null Het
Kmt2c G T 5: 25,366,200 probably benign Het
Krt39 T C 11: 99,521,206 N18S probably benign Het
Lcor G T 19: 41,559,150 G391V probably damaging Het
Mical2 A T 7: 112,351,373 T845S probably benign Het
Mon1b G T 8: 113,638,823 R261L possibly damaging Het
Mphosph8 C T 14: 56,674,210 A230V probably benign Het
Myh2 T A 11: 67,186,691 M884K probably benign Het
Nlrp3 T C 11: 59,548,401 L268P probably damaging Het
Ntng1 T A 3: 110,135,394 T39S probably benign Het
Olfr1043 A T 2: 86,162,729 Y73* probably null Het
Olfr1124 T A 2: 87,435,057 I190K probably damaging Het
Olfr342 A C 2: 36,528,144 H244P probably damaging Het
Pde4b T A 4: 102,255,297 M26K possibly damaging Het
Polh G A 17: 46,194,292 Q133* probably null Het
Postn A T 3: 54,377,204 N647I possibly damaging Het
Scimp T A 11: 70,791,561 I110F possibly damaging Het
Sell A G 1: 164,065,596 D127G probably damaging Het
Serpinb12 G A 1: 106,955,490 probably null Het
She A G 3: 89,832,066 E188G probably damaging Het
Slc22a1 T C 17: 12,667,239 Y169C probably damaging Het
Slco2a1 C T 9: 103,046,758 T57I probably damaging Het
Sox2 A T 3: 34,650,596 M61L probably benign Het
Sra1 G A 18: 36,670,097 Q32* probably null Het
Syne2 T A 12: 76,022,279 S4340T possibly damaging Het
Ucn A C 5: 31,138,394 W43G possibly damaging Het
Xdh C T 17: 73,906,246 M836I probably damaging Het
Xirp2 T A 2: 67,511,247 D1277E probably damaging Het
Other mutations in Cyp4a32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02225:Cyp4a32 APN 4 115610503 missense probably benign
IGL02546:Cyp4a32 APN 4 115611323 missense probably damaging 0.98
IGL02663:Cyp4a32 APN 4 115610590 missense probably damaging 1.00
IGL02832:Cyp4a32 APN 4 115614621 missense probably damaging 0.99
IGL03283:Cyp4a32 APN 4 115611083 missense possibly damaging 0.79
IGL03357:Cyp4a32 APN 4 115611601 missense probably benign 0.00
IGL03406:Cyp4a32 APN 4 115602303 missense probably benign 0.00
R0379:Cyp4a32 UTSW 4 115621474 missense probably damaging 1.00
R1339:Cyp4a32 UTSW 4 115611563 missense probably damaging 0.98
R1435:Cyp4a32 UTSW 4 115606666 missense probably damaging 0.97
R1445:Cyp4a32 UTSW 4 115602950 nonsense probably null
R1520:Cyp4a32 UTSW 4 115614652 missense probably damaging 0.97
R1587:Cyp4a32 UTSW 4 115610534 missense probably benign 0.06
R1719:Cyp4a32 UTSW 4 115611308 missense possibly damaging 0.61
R1932:Cyp4a32 UTSW 4 115611277 missense possibly damaging 0.78
R4184:Cyp4a32 UTSW 4 115621523 missense possibly damaging 0.94
R4580:Cyp4a32 UTSW 4 115602929 splice site silent
R5004:Cyp4a32 UTSW 4 115601041 missense probably damaging 0.98
R6345:Cyp4a32 UTSW 4 115602363 missense possibly damaging 0.81
R7231:Cyp4a32 UTSW 4 115609697 missense probably damaging 1.00
R7241:Cyp4a32 UTSW 4 115602302 missense probably benign
R7419:Cyp4a32 UTSW 4 115611037 missense probably benign
R7716:Cyp4a32 UTSW 4 115601086 missense probably damaging 1.00
Z1177:Cyp4a32 UTSW 4 115611345 missense not run
Posted On2015-04-16