Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02578:Lcor'

299273

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lcor

Ensembl Gene

ENSMUSG00000025019

Gene Name

ligand dependent nuclear receptor corepressor

Synonyms

LOC381224, A630025C20Rik, Gm340, 3110023F06Rik, Mlr2

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.560) question?

Stock #

IGL02578

Quality Score

Status

Chromosome

Chromosomal Location

41471076-41574975 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 41547589 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Valine at position 391 (G391V)

Ref Sequence

ENSEMBL: ENSMUSP00000126441 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067795] [ENSMUST00000163929]

AlphaFold

Q6ZPI3

Predicted Effect

probably damaging
Transcript: ENSMUST00000067795
AA Change: G391V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000067603
Gene: ENSMUSG00000025019
AA Change: G391V

Domain	Start	End	E-Value	Type
low complexity region	36	48	N/A	INTRINSIC
Pfam:HTH_psq	350	395	1.2e-17	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000163929
AA Change: G391V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126441
Gene: ENSMUSG00000025019
AA Change: G391V

Domain	Start	End	E-Value	Type
low complexity region	36	48	N/A	INTRINSIC
Pfam:HTH_psq	350	395	5.1e-18	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca16	G	A	7: 120,023,179 (GRCm39)		probably null	Het
Ago1	T	A	4: 126,333,324 (GRCm39)	D545V	probably benign	Het
Arid2	T	C	15: 96,270,116 (GRCm39)	S1410P	probably benign	Het
Cbfa2t3	T	A	8: 123,360,187 (GRCm39)	D488V	possibly damaging	Het
Cdx2	T	C	5: 147,240,094 (GRCm39)	D194G	probably damaging	Het
Cyp4a32	A	G	4: 115,466,939 (GRCm39)	Q208R	possibly damaging	Het
Degs1	A	C	1: 182,106,592 (GRCm39)	Y222*	probably null	Het
Dnah7a	T	A	1: 53,472,074 (GRCm39)	E3564D	probably benign	Het
Dsg4	A	T	18: 20,604,250 (GRCm39)	I906F	possibly damaging	Het
Elovl3	A	G	19: 46,123,132 (GRCm39)	H236R	possibly damaging	Het
Foxp2	A	G	6: 15,376,814 (GRCm39)		probably benign	Het
Gm9892	A	T	8: 52,649,328 (GRCm39)		noncoding transcript	Het
Herc2	A	G	7: 55,756,283 (GRCm39)		probably null	Het
Hhat	A	G	1: 192,376,221 (GRCm39)	V304A	probably damaging	Het
Il16	C	T	7: 83,327,194 (GRCm39)		probably null	Het
Kansl1l	G	A	1: 66,840,848 (GRCm39)	Q151*	probably null	Het
Kmt2c	G	T	5: 25,571,198 (GRCm39)		probably benign	Het
Krt39	T	C	11: 99,412,032 (GRCm39)	N18S	probably benign	Het
Mical2	A	T	7: 111,950,580 (GRCm39)	T845S	probably benign	Het
Mon1b	G	T	8: 114,365,455 (GRCm39)	R261L	possibly damaging	Het
Mphosph8	C	T	14: 56,911,667 (GRCm39)	A230V	probably benign	Het
Myh2	T	A	11: 67,077,517 (GRCm39)	M884K	probably benign	Het
Nlrp3	T	C	11: 59,439,227 (GRCm39)	L268P	probably damaging	Het
Ntng1	T	A	3: 110,042,710 (GRCm39)	T39S	probably benign	Het
Or10ag58	T	A	2: 87,265,401 (GRCm39)	I190K	probably damaging	Het
Or1j14	A	C	2: 36,418,156 (GRCm39)	H244P	probably damaging	Het
Or5al7	A	T	2: 85,993,073 (GRCm39)	Y73*	probably null	Het
Pde4b	T	A	4: 102,112,494 (GRCm39)	M26K	possibly damaging	Het
Polh	G	A	17: 46,505,218 (GRCm39)	Q133*	probably null	Het
Postn	A	T	3: 54,284,625 (GRCm39)	N647I	possibly damaging	Het
Scimp	T	A	11: 70,682,387 (GRCm39)	I110F	possibly damaging	Het
Sell	A	G	1: 163,893,165 (GRCm39)	D127G	probably damaging	Het
Serpinb12	G	A	1: 106,883,220 (GRCm39)		probably null	Het
She	A	G	3: 89,739,373 (GRCm39)	E188G	probably damaging	Het
Shisal2a	C	T	4: 108,225,225 (GRCm39)	M112I	probably benign	Het
Slc22a1	T	C	17: 12,886,126 (GRCm39)	Y169C	probably damaging	Het
Slco2a1	C	T	9: 102,923,957 (GRCm39)	T57I	probably damaging	Het
Sox2	A	T	3: 34,704,745 (GRCm39)	M61L	probably benign	Het
Sra1	G	A	18: 36,803,150 (GRCm39)	Q32*	probably null	Het
Syne2	T	A	12: 76,069,053 (GRCm39)	S4340T	possibly damaging	Het
Ucn	A	C	5: 31,295,738 (GRCm39)	W43G	possibly damaging	Het
Xdh	C	T	17: 74,213,241 (GRCm39)	M836I	probably damaging	Het
Xirp2	T	A	2: 67,341,591 (GRCm39)	D1277E	probably damaging	Het

Other mutations in Lcor

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00737:Lcor	APN	19	41,541,139 (GRCm39)	missense	probably damaging	0.97
IGL02079:Lcor	APN	19	41,544,126 (GRCm39)	missense	probably benign	0.40
IGL02100:Lcor	APN	19	41,547,193 (GRCm39)	missense	possibly damaging	0.93
IGL02444:Lcor	APN	19	41,547,450 (GRCm39)	missense	probably damaging	0.99
IGL03072:Lcor	APN	19	41,547,253 (GRCm39)	missense	possibly damaging	0.85
IGL03118:Lcor	APN	19	41,546,808 (GRCm39)	missense	probably damaging	0.99
IGL03153:Lcor	APN	19	41,546,795 (GRCm39)	missense	probably damaging	0.98
BB003:Lcor	UTSW	19	41,571,008 (GRCm39)	missense	probably benign
BB013:Lcor	UTSW	19	41,571,008 (GRCm39)	missense	probably benign
R0006:Lcor	UTSW	19	41,573,338 (GRCm39)	missense	probably benign	0.00
R0686:Lcor	UTSW	19	41,570,811 (GRCm39)	missense	possibly damaging	0.73
R1104:Lcor	UTSW	19	41,574,502 (GRCm39)	missense	probably damaging	0.99
R1278:Lcor	UTSW	19	41,573,122 (GRCm39)	missense	probably benign	0.07
R1606:Lcor	UTSW	19	41,573,513 (GRCm39)	missense	probably benign	0.35
R1756:Lcor	UTSW	19	41,547,705 (GRCm39)	missense	probably benign
R1833:Lcor	UTSW	19	41,573,387 (GRCm39)	missense	probably benign	0.00
R1889:Lcor	UTSW	19	41,547,567 (GRCm39)	missense	probably damaging	0.99
R1905:Lcor	UTSW	19	41,572,013 (GRCm39)	missense	possibly damaging	0.73
R1913:Lcor	UTSW	19	41,546,913 (GRCm39)	missense	probably benign	0.40
R1983:Lcor	UTSW	19	41,546,806 (GRCm39)	missense	probably damaging	0.98
R2697:Lcor	UTSW	19	41,572,466 (GRCm39)	missense	probably benign	0.43
R2881:Lcor	UTSW	19	41,571,488 (GRCm39)	missense	probably damaging	1.00
R3885:Lcor	UTSW	19	41,546,795 (GRCm39)	missense	probably damaging	0.98
R3886:Lcor	UTSW	19	41,546,795 (GRCm39)	missense	probably damaging	0.98
R3888:Lcor	UTSW	19	41,546,795 (GRCm39)	missense	probably damaging	0.98
R3889:Lcor	UTSW	19	41,546,795 (GRCm39)	missense	probably damaging	0.98
R4720:Lcor	UTSW	19	41,574,334 (GRCm39)	missense	probably benign	0.04
R4864:Lcor	UTSW	19	41,573,803 (GRCm39)	missense	probably benign
R4908:Lcor	UTSW	19	41,572,601 (GRCm39)	missense	probably benign	0.00
R5160:Lcor	UTSW	19	41,544,053 (GRCm39)	missense	probably damaging	0.99
R5193:Lcor	UTSW	19	41,570,969 (GRCm39)	missense	probably damaging	1.00
R5215:Lcor	UTSW	19	41,574,371 (GRCm39)	missense	probably damaging	1.00
R5276:Lcor	UTSW	19	41,573,478 (GRCm39)	missense	probably damaging	0.98
R5319:Lcor	UTSW	19	41,574,791 (GRCm39)	missense	probably damaging	0.99
R5321:Lcor	UTSW	19	41,573,643 (GRCm39)	missense	probably damaging	1.00
R5432:Lcor	UTSW	19	41,573,042 (GRCm39)	missense	probably damaging	1.00
R5605:Lcor	UTSW	19	41,571,302 (GRCm39)	missense	probably damaging	1.00
R5941:Lcor	UTSW	19	41,574,839 (GRCm39)	missense	probably damaging	1.00
R6020:Lcor	UTSW	19	41,571,986 (GRCm39)	missense	possibly damaging	0.88
R6024:Lcor	UTSW	19	41,572,396 (GRCm39)	missense	possibly damaging	0.84
R6112:Lcor	UTSW	19	41,547,520 (GRCm39)	missense	possibly damaging	0.92
R6149:Lcor	UTSW	19	41,573,641 (GRCm39)	missense	probably damaging	1.00
R6260:Lcor	UTSW	19	41,570,810 (GRCm39)	missense	possibly damaging	0.73
R6260:Lcor	UTSW	19	41,570,809 (GRCm39)	missense	probably null	0.91
R6476:Lcor	UTSW	19	41,571,518 (GRCm39)	missense	probably benign	0.04
R7051:Lcor	UTSW	19	41,574,191 (GRCm39)	missense	probably benign	0.05
R7285:Lcor	UTSW	19	41,572,754 (GRCm39)	missense	possibly damaging	0.91
R7372:Lcor	UTSW	19	41,573,945 (GRCm39)	missense	probably damaging	1.00
R7762:Lcor	UTSW	19	41,572,106 (GRCm39)	missense	probably benign	0.02
R7777:Lcor	UTSW	19	41,547,234 (GRCm39)	missense	probably benign	0.33
R7833:Lcor	UTSW	19	41,573,024 (GRCm39)	missense	probably benign	0.02
R7926:Lcor	UTSW	19	41,571,008 (GRCm39)	missense	probably benign
R8164:Lcor	UTSW	19	41,573,849 (GRCm39)	missense	probably damaging	1.00
R8319:Lcor	UTSW	19	41,571,343 (GRCm39)	missense	probably damaging	1.00
R8323:Lcor	UTSW	19	41,572,036 (GRCm39)	missense	probably benign	0.01
R8327:Lcor	UTSW	19	41,570,996 (GRCm39)	missense	probably damaging	1.00
R8423:Lcor	UTSW	19	41,573,888 (GRCm39)	missense	possibly damaging	0.95
R8556:Lcor	UTSW	19	41,546,863 (GRCm39)	frame shift	probably null
R8780:Lcor	UTSW	19	41,573,698 (GRCm39)	missense	probably damaging	1.00
R8781:Lcor	UTSW	19	41,573,698 (GRCm39)	missense	probably damaging	1.00
R8788:Lcor	UTSW	19	41,573,698 (GRCm39)	missense	probably damaging	1.00
R8798:Lcor	UTSW	19	41,573,698 (GRCm39)	missense	probably damaging	1.00
R9013:Lcor	UTSW	19	41,573,189 (GRCm39)	missense	probably damaging	1.00
R9035:Lcor	UTSW	19	41,573,399 (GRCm39)	missense	probably benign	0.00
R9065:Lcor	UTSW	19	41,573,698 (GRCm39)	missense	probably damaging	1.00
R9067:Lcor	UTSW	19	41,573,698 (GRCm39)	missense	probably damaging	1.00
R9083:Lcor	UTSW	19	41,574,839 (GRCm39)	missense	probably damaging	0.99
R9105:Lcor	UTSW	19	41,573,311 (GRCm39)	missense	possibly damaging	0.88
R9487:Lcor	UTSW	19	41,573,685 (GRCm39)	missense	probably damaging	1.00
R9573:Lcor	UTSW	19	41,573,471 (GRCm39)	missense	probably damaging	1.00
R9704:Lcor	UTSW	19	41,572,498 (GRCm39)	missense	possibly damaging	0.61
X0013:Lcor	UTSW	19	41,572,971 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-04-16