Incidental Mutation 'IGL02579:Zfp385c'
ID 299293
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp385c
Ensembl Gene ENSMUSG00000014198
Gene Name zinc finger protein 385C
Synonyms A930006D11Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # IGL02579
Quality Score
Status
Chromosome 11
Chromosomal Location 100518369-100583281 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 100521605 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Cysteine at position 152 (G152C)
Ref Sequence ENSEMBL: ENSMUSP00000099408 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017981] [ENSMUST00000051947] [ENSMUST00000103119] [ENSMUST00000107376] [ENSMUST00000142993]
AlphaFold A2A5E6
Predicted Effect probably benign
Transcript: ENSMUST00000017981
SMART Domains Protein: ENSMUSP00000017981
Gene: ENSMUSG00000017837

DomainStartEndE-ValueType
Pfam:Arf 1 168 4.3e-9 PFAM
Pfam:Roc 6 124 2.2e-13 PFAM
Pfam:MMR_HSR1 6 165 3.1e-6 PFAM
Pfam:Ras 6 170 2.9e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000051947
SMART Domains Protein: ENSMUSP00000059559
Gene: ENSMUSG00000017837

DomainStartEndE-ValueType
Pfam:Arf 1 168 5.6e-9 PFAM
Pfam:Miro 6 123 2.2e-21 PFAM
Pfam:Ras 6 170 4.5e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000103119
AA Change: G152C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099408
Gene: ENSMUSG00000014198
AA Change: G152C

DomainStartEndE-ValueType
low complexity region 2 24 N/A INTRINSIC
ZnF_U1 72 108 4.36e-2 SMART
ZnF_C2H2 77 99 1.51e0 SMART
low complexity region 125 141 N/A INTRINSIC
low complexity region 143 161 N/A INTRINSIC
low complexity region 181 200 N/A INTRINSIC
ZnF_U1 225 259 5.72e-4 SMART
ZnF_C2H2 228 252 7.11e0 SMART
ZnF_U1 294 328 7.44e-3 SMART
ZnF_C2H2 297 321 4.34e0 SMART
low complexity region 347 365 N/A INTRINSIC
low complexity region 382 405 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000107376
SMART Domains Protein: ENSMUSP00000102999
Gene: ENSMUSG00000017837

DomainStartEndE-ValueType
Pfam:Arf 1 168 5.6e-9 PFAM
Pfam:Miro 6 123 2.2e-21 PFAM
Pfam:Ras 6 170 4.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142993
SMART Domains Protein: ENSMUSP00000114456
Gene: ENSMUSG00000017837

DomainStartEndE-ValueType
Pfam:Arf 1 151 1.3e-8 PFAM
Pfam:Miro 6 123 1.4e-21 PFAM
Pfam:MMR_HSR1 6 145 4.5e-6 PFAM
Pfam:Ras 6 153 2.9e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148560
Predicted Effect unknown
Transcript: ENSMUST00000151589
AA Change: G231C
SMART Domains Protein: ENSMUSP00000119259
Gene: ENSMUSG00000014198
AA Change: G231C

DomainStartEndE-ValueType
ZnF_U1 40 74 6.04e-3 SMART
ZnF_C2H2 43 67 6.31e1 SMART
low complexity region 79 104 N/A INTRINSIC
ZnF_U1 152 188 4.36e-2 SMART
ZnF_C2H2 157 179 1.51e0 SMART
low complexity region 205 221 N/A INTRINSIC
low complexity region 223 241 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155840
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A G 5: 9,005,537 (GRCm39) E1140G probably damaging Het
Alcam T C 16: 52,091,135 (GRCm39) E461G probably damaging Het
Bahcc1 A G 11: 120,176,175 (GRCm39) probably benign Het
Calhm6 C A 10: 34,003,423 (GRCm39) M161I probably benign Het
Dnmt1 A G 9: 20,829,416 (GRCm39) M729T possibly damaging Het
Enpep G A 3: 129,077,739 (GRCm39) T626M probably benign Het
Gje1 A T 10: 14,592,492 (GRCm39) C97S probably benign Het
Igkv4-58 T A 6: 69,477,385 (GRCm39) I71F probably damaging Het
Itfg1 G A 8: 86,507,194 (GRCm39) T222M possibly damaging Het
Mon1b G T 8: 114,365,455 (GRCm39) R261L possibly damaging Het
Mtmr6 T A 14: 60,519,378 (GRCm39) probably benign Het
Nwd1 A T 8: 73,434,155 (GRCm39) I1251F probably damaging Het
Or5b101 T C 19: 13,004,892 (GRCm39) D267G probably damaging Het
Pip5k1c C A 10: 81,153,155 (GRCm39) probably null Het
Pold1 T C 7: 44,192,703 (GRCm39) E53G probably damaging Het
Prkdc A T 16: 15,488,465 (GRCm39) D529V possibly damaging Het
Rgl2 A G 17: 34,156,134 (GRCm39) T741A probably benign Het
Tex44 A G 1: 86,354,169 (GRCm39) N26S probably benign Het
Traf5 G T 1: 191,731,848 (GRCm39) P28Q probably damaging Het
Ttn A G 2: 76,589,433 (GRCm39) Y21274H probably damaging Het
Vmn2r76 T A 7: 85,877,961 (GRCm39) K479* probably null Het
Zfp322a A T 13: 23,541,613 (GRCm39) V43E probably damaging Het
Zfpm2 A T 15: 40,962,868 (GRCm39) N177Y possibly damaging Het
Other mutations in Zfp385c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Zfp385c APN 11 100,519,845 (GRCm39) missense probably damaging 1.00
IGL02542:Zfp385c APN 11 100,520,742 (GRCm39) missense probably damaging 1.00
IGL03243:Zfp385c APN 11 100,525,573 (GRCm39) missense probably damaging 1.00
R0054:Zfp385c UTSW 11 100,520,782 (GRCm39) missense probably benign 0.08
R0054:Zfp385c UTSW 11 100,520,782 (GRCm39) missense probably benign 0.08
R1158:Zfp385c UTSW 11 100,520,709 (GRCm39) unclassified probably benign
R1884:Zfp385c UTSW 11 100,521,532 (GRCm39) missense probably benign
R1892:Zfp385c UTSW 11 100,528,630 (GRCm39) missense probably damaging 1.00
R6010:Zfp385c UTSW 11 100,548,363 (GRCm39) missense probably benign 0.00
R6020:Zfp385c UTSW 11 100,523,594 (GRCm39) missense probably benign
R6901:Zfp385c UTSW 11 100,523,585 (GRCm39) missense probably benign 0.06
R7008:Zfp385c UTSW 11 100,521,513 (GRCm39) missense probably damaging 0.99
R7272:Zfp385c UTSW 11 100,520,865 (GRCm39) missense possibly damaging 0.50
R8271:Zfp385c UTSW 11 100,548,291 (GRCm39) missense probably damaging 1.00
Z1177:Zfp385c UTSW 11 100,548,257 (GRCm39) missense probably damaging 0.99
Z1177:Zfp385c UTSW 11 100,528,599 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16