Incidental Mutation 'IGL02579:Itfg1'
ID299305
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Itfg1
Ensembl Gene ENSMUSG00000031703
Gene Nameintegrin alpha FG-GAP repeat containing 1
SynonymsD8Wsu49e, 2310047C21Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.110) question?
Stock #IGL02579
Quality Score
Status
Chromosome8
Chromosomal Location85717578-85840921 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 85780565 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Methionine at position 222 (T222M)
Ref Sequence ENSEMBL: ENSMUSP00000034140 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034140]
Predicted Effect possibly damaging
Transcript: ENSMUST00000034140
AA Change: T222M

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000034140
Gene: ENSMUSG00000031703
AA Change: T222M

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
SCOP:d1m1xa4 46 232 5e-3 SMART
low complexity region 482 496 N/A INTRINSIC
transmembrane domain 564 586 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A G 5: 8,955,537 E1140G probably damaging Het
Alcam T C 16: 52,270,772 E461G probably damaging Het
Bahcc1 A G 11: 120,285,349 probably benign Het
Dnmt1 A G 9: 20,918,120 M729T possibly damaging Het
Enpep G A 3: 129,284,090 T626M probably benign Het
Fam26f C A 10: 34,127,427 M161I probably benign Het
Gje1 A T 10: 14,716,748 C97S probably benign Het
Igkv4-58 T A 6: 69,500,401 I71F probably damaging Het
Mon1b G T 8: 113,638,823 R261L possibly damaging Het
Mtmr6 T A 14: 60,281,929 probably benign Het
Nwd1 A T 8: 72,707,527 I1251F probably damaging Het
Olfr1453 T C 19: 13,027,528 D267G probably damaging Het
Pip5k1c C A 10: 81,317,321 probably null Het
Pold1 T C 7: 44,543,279 E53G probably damaging Het
Prkdc A T 16: 15,670,601 D529V possibly damaging Het
Rgl2 A G 17: 33,937,160 T741A probably benign Het
Tex44 A G 1: 86,426,447 N26S probably benign Het
Traf5 G T 1: 191,999,887 P28Q probably damaging Het
Ttn A G 2: 76,759,089 Y21274H probably damaging Het
Vmn2r76 T A 7: 86,228,753 K479* probably null Het
Zfp322a A T 13: 23,357,443 V43E probably damaging Het
Zfp385c C A 11: 100,630,779 G152C probably damaging Het
Zfpm2 A T 15: 41,099,472 N177Y possibly damaging Het
Other mutations in Itfg1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02803:Itfg1 APN 8 85725511 splice site probably null
R0368:Itfg1 UTSW 8 85764407 missense probably damaging 1.00
R0755:Itfg1 UTSW 8 85726205 missense possibly damaging 0.90
R1183:Itfg1 UTSW 8 85780523 missense probably benign 0.04
R1529:Itfg1 UTSW 8 85810614 missense probably benign 0.02
R1789:Itfg1 UTSW 8 85725512 critical splice donor site probably null
R1953:Itfg1 UTSW 8 85831231 missense probably benign 0.31
R2206:Itfg1 UTSW 8 85776198 missense probably benign 0.17
R2207:Itfg1 UTSW 8 85776198 missense probably benign 0.17
R2260:Itfg1 UTSW 8 85722677 missense probably damaging 1.00
R2358:Itfg1 UTSW 8 85738129 missense probably damaging 1.00
R2876:Itfg1 UTSW 8 85780510 splice site probably benign
R2990:Itfg1 UTSW 8 85835049 missense possibly damaging 0.82
R4484:Itfg1 UTSW 8 85726249 missense probably damaging 1.00
R4762:Itfg1 UTSW 8 85732441 missense possibly damaging 0.95
R5146:Itfg1 UTSW 8 85718868 makesense probably null
R5796:Itfg1 UTSW 8 85718893 missense probably damaging 1.00
R5805:Itfg1 UTSW 8 85766972 missense probably benign 0.04
R6084:Itfg1 UTSW 8 85726170 missense probably benign 0.01
R6187:Itfg1 UTSW 8 85836465 missense probably damaging 1.00
R6319:Itfg1 UTSW 8 85840629 missense probably damaging 1.00
R6463:Itfg1 UTSW 8 85736151 missense probably benign 0.03
R6490:Itfg1 UTSW 8 85740301 missense probably benign 0.08
R6492:Itfg1 UTSW 8 85740349 missense probably benign 0.14
R6588:Itfg1 UTSW 8 85736130 missense probably benign
R6753:Itfg1 UTSW 8 85835078 missense probably benign 0.04
R7489:Itfg1 UTSW 8 85767001 missense probably damaging 1.00
R7665:Itfg1 UTSW 8 85764350 missense probably benign
X0067:Itfg1 UTSW 8 85840753 unclassified probably benign
Posted On2015-04-16