Incidental Mutation 'IGL02580:Olfr1158'
ID299312
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1158
Ensembl Gene ENSMUSG00000062793
Gene Nameolfactory receptor 1158
SynonymsMOR173-3, GA_x6K02T2Q125-49480812-49481753
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL02580
Quality Score
Status
Chromosome2
Chromosomal Location87990113-87991054 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 87990513 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 134 (V134A)
Ref Sequence ENSEMBL: ENSMUSP00000099682 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102622]
Predicted Effect probably benign
Transcript: ENSMUST00000102622
AA Change: V134A

PolyPhen 2 Score 0.091 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000099682
Gene: ENSMUSG00000062793
AA Change: V134A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.5e-45 PFAM
Pfam:7tm_1 41 289 4.5e-15 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acpp A T 9: 104,326,948 I49N probably damaging Het
Aqp8 T C 7: 123,466,730 probably benign Het
Atrnl1 T C 19: 57,714,576 probably benign Het
Cdh1 A G 8: 106,649,018 T63A probably benign Het
Cenpf A G 1: 189,657,441 L1398S probably benign Het
Ctdp1 T A 18: 80,450,090 S397C probably benign Het
Cyp2c37 T A 19: 39,994,498 V177D probably damaging Het
Elmo3 A T 8: 105,308,494 D419V probably damaging Het
Fabp1 T C 6: 71,203,144 S100P probably damaging Het
Hcfc2 A T 10: 82,728,422 N485I probably benign Het
Igkv10-95 A G 6: 68,680,652 T51A probably benign Het
Iqub A G 6: 24,501,399 I184T probably benign Het
Map2k6 G A 11: 110,490,841 R71H probably damaging Het
Mon1b G T 8: 113,638,823 R261L possibly damaging Het
Ncapg2 T C 12: 116,420,689 S257P probably damaging Het
Nusap1 T C 2: 119,648,890 probably benign Het
Nwd2 A G 5: 63,808,169 R1699G probably damaging Het
Olfm3 A G 3: 115,122,508 N363S probably damaging Het
Olfr578 C T 7: 102,984,702 S154N probably damaging Het
Pirb T C 7: 3,714,206 probably null Het
Plch2 G A 4: 154,984,764 T1135I probably benign Het
Riox2 G A 16: 59,486,573 V276I probably benign Het
Slc11a1 A G 1: 74,380,259 D144G probably damaging Het
Usp40 C A 1: 87,980,966 probably null Het
Vars2 G A 17: 35,660,885 A73V possibly damaging Het
Other mutations in Olfr1158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Olfr1158 APN 2 87990438 missense probably damaging 1.00
IGL01287:Olfr1158 APN 2 87990944 missense probably benign 0.01
IGL01374:Olfr1158 APN 2 87990548 missense probably benign
IGL01821:Olfr1158 APN 2 87990589 missense probably benign 0.12
IGL01832:Olfr1158 APN 2 87990169 missense probably benign 0.02
IGL02327:Olfr1158 APN 2 87990257 missense probably damaging 1.00
IGL03001:Olfr1158 APN 2 87990149 missense probably benign 0.43
IGL03196:Olfr1158 APN 2 87990482 missense possibly damaging 0.67
R0546:Olfr1158 UTSW 2 87990472 nonsense probably null
R1474:Olfr1158 UTSW 2 87990990 missense probably damaging 1.00
R1650:Olfr1158 UTSW 2 87990801 missense probably benign 0.01
R1757:Olfr1158 UTSW 2 87990582 missense probably damaging 0.99
R2992:Olfr1158 UTSW 2 87990777 missense probably benign 0.00
R4038:Olfr1158 UTSW 2 87990918 missense possibly damaging 0.88
R5190:Olfr1158 UTSW 2 87990763 nonsense probably null
R5871:Olfr1158 UTSW 2 87991011 missense possibly damaging 0.82
R8220:Olfr1158 UTSW 2 87990152 missense probably damaging 1.00
Posted On2015-04-16