Incidental Mutation 'IGL02580:Olfm3'
ID 299325
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfm3
Ensembl Gene ENSMUSG00000027965
Gene Name olfactomedin 3
Synonyms B230206G02Rik, optimedin
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # IGL02580
Quality Score
Status
Chromosome 3
Chromosomal Location 114697727-114919371 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 114916157 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 363 (N363S)
Ref Sequence ENSEMBL: ENSMUSP00000060985 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051309] [ENSMUST00000081752] [ENSMUST00000149158]
AlphaFold P63056
Predicted Effect probably damaging
Transcript: ENSMUST00000051309
AA Change: N363S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000060985
Gene: ENSMUSG00000027965
AA Change: N363S

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Noelin-1 46 145 3.9e-52 PFAM
Blast:OLF 162 207 3e-8 BLAST
OLF 220 470 4.33e-114 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000081752
AA Change: N343S

PolyPhen 2 Score 0.139 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000080448
Gene: ENSMUSG00000027965
AA Change: N343S

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Noelin-1 25 125 7.6e-54 PFAM
Blast:OLF 142 187 3e-8 BLAST
OLF 200 450 4.33e-114 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000149158
SMART Domains Protein: ENSMUSP00000121097
Gene: ENSMUSG00000027965

DomainStartEndE-ValueType
Pfam:Noelin-1 12 112 2.5e-51 PFAM
Blast:OLF 129 174 1e-8 BLAST
Blast:OLF 187 210 1e-7 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp3 A T 9: 104,204,147 (GRCm39) I49N probably damaging Het
Aqp8 T C 7: 123,065,953 (GRCm39) probably benign Het
Atrnl1 T C 19: 57,703,008 (GRCm39) probably benign Het
Cdh1 A G 8: 107,375,650 (GRCm39) T63A probably benign Het
Cenpf A G 1: 189,389,638 (GRCm39) L1398S probably benign Het
Ctdp1 T A 18: 80,493,305 (GRCm39) S397C probably benign Het
Cyp2c37 T A 19: 39,982,942 (GRCm39) V177D probably damaging Het
Elmo3 A T 8: 106,035,126 (GRCm39) D419V probably damaging Het
Fabp1 T C 6: 71,180,128 (GRCm39) S100P probably damaging Het
Hcfc2 A T 10: 82,564,256 (GRCm39) N485I probably benign Het
Igkv10-95 A G 6: 68,657,636 (GRCm39) T51A probably benign Het
Iqub A G 6: 24,501,398 (GRCm39) I184T probably benign Het
Map2k6 G A 11: 110,381,667 (GRCm39) R71H probably damaging Het
Mon1b G T 8: 114,365,455 (GRCm39) R261L possibly damaging Het
Ncapg2 T C 12: 116,384,309 (GRCm39) S257P probably damaging Het
Nusap1 T C 2: 119,479,371 (GRCm39) probably benign Het
Nwd2 A G 5: 63,965,512 (GRCm39) R1699G probably damaging Het
Or51g1 C T 7: 102,633,909 (GRCm39) S154N probably damaging Het
Or9m2 T C 2: 87,820,857 (GRCm39) V134A probably benign Het
Pirb T C 7: 3,717,205 (GRCm39) probably null Het
Plch2 G A 4: 155,069,221 (GRCm39) T1135I probably benign Het
Riox2 G A 16: 59,306,936 (GRCm39) V276I probably benign Het
Slc11a1 A G 1: 74,419,418 (GRCm39) D144G probably damaging Het
Usp40 C A 1: 87,908,688 (GRCm39) probably null Het
Vars2 G A 17: 35,971,777 (GRCm39) A73V possibly damaging Het
Other mutations in Olfm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01656:Olfm3 APN 3 114,916,282 (GRCm39) missense probably damaging 1.00
IGL01686:Olfm3 APN 3 114,916,497 (GRCm39) missense probably benign 0.00
IGL01732:Olfm3 APN 3 114,890,649 (GRCm39) missense possibly damaging 0.82
IGL02539:Olfm3 APN 3 114,895,579 (GRCm39) missense possibly damaging 0.93
IGL02999:Olfm3 APN 3 114,916,397 (GRCm39) missense probably damaging 1.00
IGL03142:Olfm3 APN 3 114,890,679 (GRCm39) missense probably damaging 0.97
IGL03239:Olfm3 APN 3 114,916,243 (GRCm39) missense probably damaging 0.99
R0361:Olfm3 UTSW 3 114,914,622 (GRCm39) missense probably damaging 1.00
R0373:Olfm3 UTSW 3 114,916,454 (GRCm39) missense probably damaging 0.99
R0505:Olfm3 UTSW 3 114,916,330 (GRCm39) missense possibly damaging 0.46
R0689:Olfm3 UTSW 3 114,916,194 (GRCm39) missense probably benign 0.28
R0973:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R0973:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R0974:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R1253:Olfm3 UTSW 3 114,916,418 (GRCm39) missense probably damaging 0.98
R1293:Olfm3 UTSW 3 114,895,579 (GRCm39) missense possibly damaging 0.93
R1952:Olfm3 UTSW 3 114,895,589 (GRCm39) missense probably null 1.00
R2255:Olfm3 UTSW 3 114,915,842 (GRCm39) splice site probably null
R2334:Olfm3 UTSW 3 114,895,608 (GRCm39) nonsense probably null
R2510:Olfm3 UTSW 3 114,915,959 (GRCm39) missense probably damaging 1.00
R4222:Olfm3 UTSW 3 114,883,820 (GRCm39) nonsense probably null
R4716:Olfm3 UTSW 3 114,874,755 (GRCm39) missense probably benign 0.00
R4912:Olfm3 UTSW 3 114,895,589 (GRCm39) missense probably damaging 1.00
R5084:Olfm3 UTSW 3 114,698,202 (GRCm39) critical splice donor site probably null
R5649:Olfm3 UTSW 3 114,890,573 (GRCm39) missense probably damaging 0.99
R5681:Olfm3 UTSW 3 114,915,924 (GRCm39) missense probably benign 0.28
R5861:Olfm3 UTSW 3 114,916,052 (GRCm39) missense probably damaging 1.00
R5924:Olfm3 UTSW 3 114,916,187 (GRCm39) missense probably benign 0.44
R5929:Olfm3 UTSW 3 114,895,529 (GRCm39) missense probably damaging 0.97
R5958:Olfm3 UTSW 3 114,915,955 (GRCm39) missense probably damaging 0.99
R6166:Olfm3 UTSW 3 114,916,074 (GRCm39) missense probably damaging 1.00
R6299:Olfm3 UTSW 3 114,914,632 (GRCm39) missense probably damaging 1.00
R6804:Olfm3 UTSW 3 114,916,328 (GRCm39) missense probably benign 0.10
R7032:Olfm3 UTSW 3 114,883,805 (GRCm39) missense probably damaging 1.00
R7565:Olfm3 UTSW 3 114,916,393 (GRCm39) missense probably damaging 0.98
R7600:Olfm3 UTSW 3 114,890,589 (GRCm39) missense possibly damaging 0.65
R7976:Olfm3 UTSW 3 114,874,794 (GRCm39) missense probably benign 0.00
R8070:Olfm3 UTSW 3 114,895,604 (GRCm39) missense probably damaging 0.96
R8334:Olfm3 UTSW 3 114,916,206 (GRCm39) missense probably damaging 0.96
R8527:Olfm3 UTSW 3 114,916,196 (GRCm39) missense probably benign 0.10
R8542:Olfm3 UTSW 3 114,916,196 (GRCm39) missense probably benign 0.10
R8835:Olfm3 UTSW 3 114,916,061 (GRCm39) missense probably damaging 1.00
R9063:Olfm3 UTSW 3 114,914,582 (GRCm39) missense probably benign 0.36
R9594:Olfm3 UTSW 3 114,883,785 (GRCm39) missense probably damaging 1.00
R9690:Olfm3 UTSW 3 114,890,594 (GRCm39) nonsense probably null
R9690:Olfm3 UTSW 3 114,890,593 (GRCm39) missense probably benign 0.39
R9719:Olfm3 UTSW 3 114,916,091 (GRCm39) nonsense probably null
Z1088:Olfm3 UTSW 3 114,698,317 (GRCm39) start gained probably benign
Z1177:Olfm3 UTSW 3 114,874,750 (GRCm39) missense probably benign 0.01
Posted On 2015-04-16