Incidental Mutation 'IGL02584:Gm21698'
ID299463
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm21698
Ensembl Gene ENSMUSG00000096045
Gene Namepredicted gene, 21698
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #IGL02584
Quality Score
Status
Chromosome5
Chromosomal Location25982030-25988650 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 25987393 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Valine at position 65 (E65V)
Ref Sequence ENSEMBL: ENSMUSP00000140294 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178487] [ENSMUST00000191203]
Predicted Effect probably damaging
Transcript: ENSMUST00000178487
AA Change: E19V

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000137405
Gene: ENSMUSG00000096045
AA Change: E19V

DomainStartEndE-ValueType
Pfam:Takusan 3 89 5.1e-18 PFAM
coiled coil region 150 177 N/A INTRINSIC
low complexity region 201 215 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000191203
AA Change: E65V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000140294
Gene: ENSMUSG00000096045
AA Change: E65V

DomainStartEndE-ValueType
Pfam:Takusan 49 135 4.8e-19 PFAM
coiled coil region 196 223 N/A INTRINSIC
low complexity region 247 261 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110057P08Rik A T 16: 89,174,856 Y22F unknown Het
Adgrb3 A G 1: 25,504,984 L312P probably damaging Het
Anpep T C 7: 79,825,393 probably benign Het
Arhgef6 T G X: 57,246,378 probably benign Het
Catsperg1 T C 7: 29,184,721 D989G probably damaging Het
Ccnj T A 19: 40,844,741 V121E probably benign Het
Cdyl T C 13: 35,683,786 L15P probably benign Het
Cnrip1 T A 11: 17,078,536 M156K probably damaging Het
Cryga T A 1: 65,103,016 S73C probably benign Het
Dennd4a A G 9: 64,851,298 T240A probably damaging Het
Eml6 A G 11: 29,749,387 S1789P probably damaging Het
Esr2 A T 12: 76,145,262 W331R probably damaging Het
Fbxo18 A T 2: 11,759,958 L455H probably benign Het
Grm8 G T 6: 27,762,439 F262L probably benign Het
Haus3 A T 5: 34,166,258 L336* probably null Het
Hfm1 A C 5: 106,878,662 probably null Het
Hgfac T C 5: 35,043,961 probably benign Het
Ighv1-22 T C 12: 114,746,322 E101G probably benign Het
Impg2 A G 16: 56,265,011 E1027G probably damaging Het
Lypd5 A T 7: 24,353,568 T217S possibly damaging Het
Myrf A G 19: 10,212,223 probably benign Het
Mzf1 A G 7: 13,052,817 W109R probably damaging Het
Ndufb4 A T 16: 37,649,170 probably benign Het
Ntn1 A G 11: 68,277,530 V367A probably damaging Het
Olfr1029 C T 2: 85,975,875 L211F probably damaging Het
Oprk1 A G 1: 5,598,604 K91R probably damaging Het
Pdlim1 A G 19: 40,243,400 probably null Het
Ppp1r11 G A 17: 36,949,889 R61C probably damaging Het
Racgap1 T C 15: 99,623,634 D547G probably benign Het
Sema4b A G 7: 80,224,988 T709A probably benign Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Supt5 T C 7: 28,326,167 H218R probably benign Het
Tmem132c T A 5: 127,504,999 I426N probably damaging Het
Tpcn1 T C 5: 120,539,032 N696S probably damaging Het
Ttn T C 2: 76,736,162 N26383S possibly damaging Het
Vax2 A G 6: 83,711,513 T73A probably benign Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Other mutations in Gm21698
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4581001:Gm21698 UTSW 5 25987352 missense probably benign 0.08
R6172:Gm21698 UTSW 5 25987373 missense probably benign 0.25
R7110:Gm21698 UTSW 5 25985177 missense probably damaging 1.00
R7904:Gm21698 UTSW 5 25984258 missense probably benign 0.16
Posted On2015-04-16