Incidental Mutation 'IGL02584:Ccnj'
ID299474
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccnj
Ensembl Gene ENSMUSG00000025010
Gene Namecyclin J
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.148) question?
Stock #IGL02584
Quality Score
Status
Chromosome19
Chromosomal Location40831279-40848572 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 40844741 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 121 (V121E)
Ref Sequence ENSEMBL: ENSMUSP00000113712 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025983] [ENSMUST00000119316] [ENSMUST00000120057]
Predicted Effect probably benign
Transcript: ENSMUST00000025983
AA Change: V121E

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000025983
Gene: ENSMUSG00000025010
AA Change: V121E

DomainStartEndE-ValueType
CYCLIN 45 136 1.59e-13 SMART
Cyclin_C 145 282 7.02e-21 SMART
CYCLIN 153 248 2.1e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119316
AA Change: V121E

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000112643
Gene: ENSMUSG00000025010
AA Change: V121E

DomainStartEndE-ValueType
CYCLIN 45 136 1.59e-13 SMART
Cyclin_C 145 282 7.02e-21 SMART
CYCLIN 153 248 2.1e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120057
AA Change: V121E

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000113712
Gene: ENSMUSG00000025010
AA Change: V121E

DomainStartEndE-ValueType
CYCLIN 45 136 1.59e-13 SMART
Cyclin_C 145 270 6.99e-7 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110057P08Rik A T 16: 89,174,856 Y22F unknown Het
Adgrb3 A G 1: 25,504,984 L312P probably damaging Het
Anpep T C 7: 79,825,393 probably benign Het
Arhgef6 T G X: 57,246,378 probably benign Het
Catsperg1 T C 7: 29,184,721 D989G probably damaging Het
Cdyl T C 13: 35,683,786 L15P probably benign Het
Cnrip1 T A 11: 17,078,536 M156K probably damaging Het
Cryga T A 1: 65,103,016 S73C probably benign Het
Dennd4a A G 9: 64,851,298 T240A probably damaging Het
Eml6 A G 11: 29,749,387 S1789P probably damaging Het
Esr2 A T 12: 76,145,262 W331R probably damaging Het
Fbxo18 A T 2: 11,759,958 L455H probably benign Het
Gm21698 T A 5: 25,987,393 E65V probably damaging Het
Grm8 G T 6: 27,762,439 F262L probably benign Het
Haus3 A T 5: 34,166,258 L336* probably null Het
Hfm1 A C 5: 106,878,662 probably null Het
Hgfac T C 5: 35,043,961 probably benign Het
Ighv1-22 T C 12: 114,746,322 E101G probably benign Het
Impg2 A G 16: 56,265,011 E1027G probably damaging Het
Lypd5 A T 7: 24,353,568 T217S possibly damaging Het
Myrf A G 19: 10,212,223 probably benign Het
Mzf1 A G 7: 13,052,817 W109R probably damaging Het
Ndufb4 A T 16: 37,649,170 probably benign Het
Ntn1 A G 11: 68,277,530 V367A probably damaging Het
Olfr1029 C T 2: 85,975,875 L211F probably damaging Het
Oprk1 A G 1: 5,598,604 K91R probably damaging Het
Pdlim1 A G 19: 40,243,400 probably null Het
Ppp1r11 G A 17: 36,949,889 R61C probably damaging Het
Racgap1 T C 15: 99,623,634 D547G probably benign Het
Sema4b A G 7: 80,224,988 T709A probably benign Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Supt5 T C 7: 28,326,167 H218R probably benign Het
Tmem132c T A 5: 127,504,999 I426N probably damaging Het
Tpcn1 T C 5: 120,539,032 N696S probably damaging Het
Ttn T C 2: 76,736,162 N26383S possibly damaging Het
Vax2 A G 6: 83,711,513 T73A probably benign Het
Zfp518a G A 19: 40,914,617 G997R probably damaging Het
Other mutations in Ccnj
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01903:Ccnj APN 19 40846010 missense probably damaging 1.00
R0220:Ccnj UTSW 19 40844810 missense probably damaging 0.99
R0452:Ccnj UTSW 19 40845064 splice site probably null
R0693:Ccnj UTSW 19 40837107 missense probably damaging 1.00
R1600:Ccnj UTSW 19 40844657 splice site probably benign
R2237:Ccnj UTSW 19 40845775 missense probably benign 0.00
R2258:Ccnj UTSW 19 40845833 missense probably benign 0.00
R2879:Ccnj UTSW 19 40844714 missense probably damaging 1.00
R6162:Ccnj UTSW 19 40845162 missense probably damaging 1.00
R6384:Ccnj UTSW 19 40846007 missense probably benign 0.09
R6528:Ccnj UTSW 19 40832085 splice site probably null
R6830:Ccnj UTSW 19 40845192 missense probably damaging 0.99
R7338:Ccnj UTSW 19 40837033 missense probably damaging 1.00
R7346:Ccnj UTSW 19 40844950 missense probably benign 0.28
R8472:Ccnj UTSW 19 40845164 missense probably damaging 0.97
Posted On2015-04-16