Incidental Mutation 'IGL02586:Lilra6'
ID 299538
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lilra6
Ensembl Gene ENSMUSG00000030427
Gene Name leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms 7M1, Pira3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # IGL02586
Quality Score
Status
Chromosome 7
Chromosomal Location 3911279-3918502 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 3911819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 280 (T280A)
Ref Sequence ENSEMBL: ENSMUSP00000145890 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]
AlphaFold A0A0B4J1F3
Predicted Effect probably benign
Transcript: ENSMUST00000038176
AA Change: T620A

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: T620A

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 40 105 3.11e0 SMART
IG 129 315 4.53e-2 SMART
IG_like 237 302 1.54e-1 SMART
IG_like 328 415 1.79e1 SMART
IG_like 429 517 2.66e1 SMART
IG 529 618 8.59e-3 SMART
low complexity region 637 646 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000090689
AA Change: T582A

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: T582A

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 34 118 7.25e0 SMART
IG_like 129 220 1.62e2 SMART
IG_like 290 377 1.79e1 SMART
IG_like 391 479 2.66e1 SMART
IG 491 580 8.59e-3 SMART
low complexity region 599 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131255
Predicted Effect probably benign
Transcript: ENSMUST00000206077
AA Change: T280A

PolyPhen 2 Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206851
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,243,983 (GRCm39) I1949V possibly damaging Het
Anapc2 T A 2: 25,175,108 (GRCm39) M742K probably benign Het
Arhgef12 T A 9: 42,917,200 (GRCm39) K380* probably null Het
Armc1 G T 3: 19,188,192 (GRCm39) probably benign Het
Bltp1 G A 3: 37,098,757 (GRCm39) W4626* probably null Het
Diaph3 A T 14: 87,223,512 (GRCm39) L323* probably null Het
Fbxo11 C T 17: 88,318,711 (GRCm39) probably benign Het
Flywch1 C T 17: 23,974,676 (GRCm39) A655T probably benign Het
Frmpd1 A G 4: 45,285,160 (GRCm39) D1327G probably damaging Het
Ggact G A 14: 123,128,942 (GRCm39) T91I possibly damaging Het
Gm10250 T A 15: 5,150,412 (GRCm39) probably benign Het
Gsdmc4 T C 15: 63,765,641 (GRCm39) S303G probably damaging Het
Helt T C 8: 46,746,276 (GRCm39) E15G probably damaging Het
Kcnf1 T A 12: 17,226,144 (GRCm39) S26C probably benign Het
Lipo3 A T 19: 33,559,539 (GRCm39) D110E possibly damaging Het
Mepe C A 5: 104,485,316 (GRCm39) T152N probably benign Het
Nr2f1 C A 13: 78,343,275 (GRCm39) probably benign Het
Or5ak24 T C 2: 85,260,810 (GRCm39) D121G possibly damaging Het
Or6c214 A G 10: 129,590,524 (GRCm39) I265T possibly damaging Het
Peg3 T C 7: 6,713,068 (GRCm39) D718G probably benign Het
Phf2 A T 13: 48,967,334 (GRCm39) probably benign Het
Pigc A T 1: 161,798,503 (GRCm39) I162F probably benign Het
Raf1 A G 6: 115,597,267 (GRCm39) L11P probably damaging Het
Rlf T C 4: 121,007,261 (GRCm39) Y573C probably damaging Het
Rnf123 G A 9: 107,945,501 (GRCm39) R390* probably null Het
Rnf149 T G 1: 39,604,296 (GRCm39) Q189P probably benign Het
Slc11a1 T C 1: 74,424,291 (GRCm39) probably benign Het
Slc22a12 C T 19: 6,590,487 (GRCm39) M234I probably benign Het
Slc28a1 A T 7: 80,814,167 (GRCm39) I455F probably benign Het
Slc35f5 T G 1: 125,512,273 (GRCm39) L358V probably damaging Het
Slc47a1 A T 11: 61,235,147 (GRCm39) V562D probably benign Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
Ushbp1 T C 8: 71,841,394 (GRCm39) probably benign Het
Vmn1r88 T A 7: 12,911,735 (GRCm39) Y30* probably null Het
Vmn2r27 A T 6: 124,201,434 (GRCm39) Y174* probably null Het
Wwox T C 8: 115,438,947 (GRCm39) Y338H possibly damaging Het
Zfp518a G A 19: 40,903,061 (GRCm39) G997R probably damaging Het
Zup1 A T 10: 33,811,261 (GRCm39) probably benign Het
Other mutations in Lilra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Lilra6 APN 7 3,914,553 (GRCm39) missense probably benign 0.04
IGL00569:Lilra6 APN 7 3,917,588 (GRCm39) missense probably damaging 0.99
IGL00899:Lilra6 APN 7 3,916,056 (GRCm39) missense probably damaging 1.00
IGL00955:Lilra6 APN 7 3,914,403 (GRCm39) splice site probably benign
IGL01585:Lilra6 APN 7 3,917,498 (GRCm39) missense probably benign 0.01
IGL02195:Lilra6 APN 7 3,917,549 (GRCm39) missense probably benign 0.00
IGL02719:Lilra6 APN 7 3,915,991 (GRCm39) missense possibly damaging 0.96
IGL03166:Lilra6 APN 7 3,915,626 (GRCm39) missense possibly damaging 0.69
IGL03329:Lilra6 APN 7 3,917,647 (GRCm39) splice site probably benign
R0233:Lilra6 UTSW 7 3,917,935 (GRCm39) missense possibly damaging 0.69
R0233:Lilra6 UTSW 7 3,917,935 (GRCm39) missense possibly damaging 0.69
R0423:Lilra6 UTSW 7 3,917,774 (GRCm39) splice site probably benign
R0483:Lilra6 UTSW 7 3,916,138 (GRCm39) missense probably benign 0.02
R0511:Lilra6 UTSW 7 3,915,784 (GRCm39) missense possibly damaging 0.77
R1472:Lilra6 UTSW 7 3,915,718 (GRCm39) missense probably damaging 1.00
R1560:Lilra6 UTSW 7 3,914,407 (GRCm39) critical splice donor site probably null
R1584:Lilra6 UTSW 7 3,915,661 (GRCm39) missense probably damaging 1.00
R1781:Lilra6 UTSW 7 3,918,066 (GRCm39) missense probably benign 0.28
R2411:Lilra6 UTSW 7 3,914,453 (GRCm39) missense probably damaging 1.00
R2420:Lilra6 UTSW 7 3,917,857 (GRCm39) missense probably damaging 1.00
R4021:Lilra6 UTSW 7 3,914,417 (GRCm39) missense probably benign 0.20
R4074:Lilra6 UTSW 7 3,917,889 (GRCm39) missense probably benign 0.23
R4284:Lilra6 UTSW 7 3,911,803 (GRCm39) missense possibly damaging 0.76
R4508:Lilra6 UTSW 7 3,915,028 (GRCm39) nonsense probably null
R4894:Lilra6 UTSW 7 3,915,530 (GRCm39) missense probably benign 0.01
R4977:Lilra6 UTSW 7 3,917,382 (GRCm39) missense probably benign 0.01
R5048:Lilra6 UTSW 7 3,918,440 (GRCm39) critical splice donor site probably null
R5164:Lilra6 UTSW 7 3,917,880 (GRCm39) missense probably damaging 1.00
R5185:Lilra6 UTSW 7 3,917,635 (GRCm39) missense probably benign 0.00
R5527:Lilra6 UTSW 7 3,917,586 (GRCm39) start gained probably benign
R6281:Lilra6 UTSW 7 3,914,972 (GRCm39) missense probably damaging 1.00
R6480:Lilra6 UTSW 7 3,915,932 (GRCm39) missense probably damaging 1.00
R6512:Lilra6 UTSW 7 3,917,387 (GRCm39) missense probably benign 0.06
R6565:Lilra6 UTSW 7 3,918,019 (GRCm39) missense probably benign
R7017:Lilra6 UTSW 7 3,911,707 (GRCm39) missense possibly damaging 0.93
R7095:Lilra6 UTSW 7 3,916,196 (GRCm39) missense probably damaging 1.00
R7747:Lilra6 UTSW 7 3,915,995 (GRCm39) missense probably benign 0.16
R8056:Lilra6 UTSW 7 3,915,551 (GRCm39) missense probably damaging 1.00
R8280:Lilra6 UTSW 7 3,916,046 (GRCm39) missense probably benign 0.01
R9197:Lilra6 UTSW 7 3,915,716 (GRCm39) missense possibly damaging 0.94
R9354:Lilra6 UTSW 7 3,914,628 (GRCm39) missense probably damaging 1.00
R9379:Lilra6 UTSW 7 3,916,166 (GRCm39) missense probably damaging 1.00
R9406:Lilra6 UTSW 7 3,917,853 (GRCm39) missense probably benign
R9462:Lilra6 UTSW 7 3,914,994 (GRCm39) missense probably damaging 0.97
R9649:Lilra6 UTSW 7 3,917,521 (GRCm39) missense possibly damaging 0.47
Z1176:Lilra6 UTSW 7 3,918,073 (GRCm39) critical splice acceptor site probably null
Z1177:Lilra6 UTSW 7 3,915,580 (GRCm39) missense possibly damaging 0.48
Posted On 2015-04-16