Incidental Mutation 'IGL02586:Lilra6'
| ID |
299538 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lilra6
|
| Ensembl Gene |
ENSMUSG00000030427 |
| Gene Name |
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 |
| Synonyms |
Pira3, 7M1 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.086)
|
| Stock # |
IGL02586
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
3908280-3915503 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 3908820 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 280
(T280A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000145890
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000038176]
[ENSMUST00000090689]
[ENSMUST00000206077]
|
| AlphaFold |
A0A0B4J1F3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000038176
AA Change: T620A
PolyPhen 2
Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: T620A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
17 |
N/A |
INTRINSIC |
|
IG_like
|
40 |
105 |
3.11e0 |
SMART |
|
IG
|
129 |
315 |
4.53e-2 |
SMART |
|
IG_like
|
237 |
302 |
1.54e-1 |
SMART |
|
IG_like
|
328 |
415 |
1.79e1 |
SMART |
|
IG_like
|
429 |
517 |
2.66e1 |
SMART |
|
IG
|
529 |
618 |
8.59e-3 |
SMART |
|
low complexity region
|
637 |
646 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000090689
AA Change: T582A
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: T582A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
17 |
N/A |
INTRINSIC |
|
IG_like
|
34 |
118 |
7.25e0 |
SMART |
|
IG_like
|
129 |
220 |
1.62e2 |
SMART |
|
IG_like
|
290 |
377 |
1.79e1 |
SMART |
|
IG_like
|
391 |
479 |
2.66e1 |
SMART |
|
IG
|
491 |
580 |
8.59e-3 |
SMART |
|
low complexity region
|
599 |
608 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131255
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206077
AA Change: T280A
PolyPhen 2
Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206851
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932438A13Rik |
G |
A |
3: 37,044,608 (GRCm38) |
W4626* |
probably null |
Het |
| Abca13 |
A |
G |
11: 9,293,983 (GRCm38) |
I1949V |
possibly damaging |
Het |
| Anapc2 |
T |
A |
2: 25,285,096 (GRCm38) |
M742K |
probably benign |
Het |
| Arhgef12 |
T |
A |
9: 43,005,904 (GRCm38) |
K380* |
probably null |
Het |
| Armc1 |
G |
T |
3: 19,134,028 (GRCm38) |
|
probably benign |
Het |
| Diaph3 |
A |
T |
14: 86,986,076 (GRCm38) |
L323* |
probably null |
Het |
| Fbxo11 |
C |
T |
17: 88,011,283 (GRCm38) |
|
probably benign |
Het |
| Flywch1 |
C |
T |
17: 23,755,702 (GRCm38) |
A655T |
probably benign |
Het |
| Frmpd1 |
A |
G |
4: 45,285,160 (GRCm38) |
D1327G |
probably damaging |
Het |
| Ggact |
G |
A |
14: 122,891,530 (GRCm38) |
T91I |
possibly damaging |
Het |
| Gm10250 |
T |
A |
15: 5,120,930 (GRCm38) |
|
probably benign |
Het |
| Gsdmc4 |
T |
C |
15: 63,893,792 (GRCm38) |
S303G |
probably damaging |
Het |
| Helt |
T |
C |
8: 46,293,239 (GRCm38) |
E15G |
probably damaging |
Het |
| Kcnf1 |
T |
A |
12: 17,176,143 (GRCm38) |
S26C |
probably benign |
Het |
| Lipo3 |
A |
T |
19: 33,582,139 (GRCm38) |
D110E |
possibly damaging |
Het |
| Mepe |
C |
A |
5: 104,337,450 (GRCm38) |
T152N |
probably benign |
Het |
| Nr2f1 |
C |
A |
13: 78,195,156 (GRCm38) |
|
probably benign |
Het |
| Olfr807 |
A |
G |
10: 129,754,655 (GRCm38) |
I265T |
possibly damaging |
Het |
| Olfr994 |
T |
C |
2: 85,430,466 (GRCm38) |
D121G |
possibly damaging |
Het |
| Peg3 |
T |
C |
7: 6,710,069 (GRCm38) |
D718G |
probably benign |
Het |
| Phf2 |
A |
T |
13: 48,813,858 (GRCm38) |
|
probably benign |
Het |
| Pigc |
A |
T |
1: 161,970,934 (GRCm38) |
I162F |
probably benign |
Het |
| Raf1 |
A |
G |
6: 115,620,306 (GRCm38) |
L11P |
probably damaging |
Het |
| Rlf |
T |
C |
4: 121,150,064 (GRCm38) |
Y573C |
probably damaging |
Het |
| Rnf123 |
G |
A |
9: 108,068,302 (GRCm38) |
R390* |
probably null |
Het |
| Rnf149 |
T |
G |
1: 39,565,215 (GRCm38) |
Q189P |
probably benign |
Het |
| Slc11a1 |
T |
C |
1: 74,385,132 (GRCm38) |
|
probably benign |
Het |
| Slc22a12 |
C |
T |
19: 6,540,457 (GRCm38) |
M234I |
probably benign |
Het |
| Slc28a1 |
A |
T |
7: 81,164,419 (GRCm38) |
I455F |
probably benign |
Het |
| Slc35f5 |
T |
G |
1: 125,584,536 (GRCm38) |
L358V |
probably damaging |
Het |
| Slc47a1 |
A |
T |
11: 61,344,321 (GRCm38) |
V562D |
probably benign |
Het |
| Srrm1 |
G |
A |
4: 135,325,104 (GRCm38) |
P658L |
unknown |
Het |
| Ushbp1 |
T |
C |
8: 71,388,750 (GRCm38) |
|
probably benign |
Het |
| Vmn1r88 |
T |
A |
7: 13,177,808 (GRCm38) |
Y30* |
probably null |
Het |
| Vmn2r27 |
A |
T |
6: 124,224,475 (GRCm38) |
Y174* |
probably null |
Het |
| Wwox |
T |
C |
8: 114,712,207 (GRCm38) |
Y338H |
possibly damaging |
Het |
| Zfp518a |
G |
A |
19: 40,914,617 (GRCm38) |
G997R |
probably damaging |
Het |
| Zufsp |
A |
T |
10: 33,935,265 (GRCm38) |
|
probably benign |
Het |
|
| Other mutations in Lilra6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00508:Lilra6
|
APN |
7 |
3,911,554 (GRCm38) |
missense |
probably benign |
0.04 |
|
IGL00569:Lilra6
|
APN |
7 |
3,914,589 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL00899:Lilra6
|
APN |
7 |
3,913,057 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00955:Lilra6
|
APN |
7 |
3,911,404 (GRCm38) |
splice site |
probably benign |
|
|
IGL01585:Lilra6
|
APN |
7 |
3,914,499 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02195:Lilra6
|
APN |
7 |
3,914,550 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02719:Lilra6
|
APN |
7 |
3,912,992 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL03166:Lilra6
|
APN |
7 |
3,912,627 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
IGL03329:Lilra6
|
APN |
7 |
3,914,648 (GRCm38) |
splice site |
probably benign |
|
|
R0233:Lilra6
|
UTSW |
7 |
3,914,936 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R0233:Lilra6
|
UTSW |
7 |
3,914,936 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R0423:Lilra6
|
UTSW |
7 |
3,914,775 (GRCm38) |
splice site |
probably benign |
|
|
R0483:Lilra6
|
UTSW |
7 |
3,913,139 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0511:Lilra6
|
UTSW |
7 |
3,912,785 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R1472:Lilra6
|
UTSW |
7 |
3,912,719 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1560:Lilra6
|
UTSW |
7 |
3,911,408 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1584:Lilra6
|
UTSW |
7 |
3,912,662 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1781:Lilra6
|
UTSW |
7 |
3,915,067 (GRCm38) |
missense |
probably benign |
0.28 |
|
R2411:Lilra6
|
UTSW |
7 |
3,911,454 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2420:Lilra6
|
UTSW |
7 |
3,914,858 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4021:Lilra6
|
UTSW |
7 |
3,911,418 (GRCm38) |
missense |
probably benign |
0.20 |
|
R4074:Lilra6
|
UTSW |
7 |
3,914,890 (GRCm38) |
missense |
probably benign |
0.23 |
|
R4284:Lilra6
|
UTSW |
7 |
3,908,804 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R4508:Lilra6
|
UTSW |
7 |
3,912,029 (GRCm38) |
nonsense |
probably null |
|
|
R4894:Lilra6
|
UTSW |
7 |
3,912,531 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4977:Lilra6
|
UTSW |
7 |
3,914,383 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5048:Lilra6
|
UTSW |
7 |
3,915,441 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5164:Lilra6
|
UTSW |
7 |
3,914,881 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5185:Lilra6
|
UTSW |
7 |
3,914,636 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5527:Lilra6
|
UTSW |
7 |
3,914,587 (GRCm38) |
start gained |
probably benign |
|
|
R6281:Lilra6
|
UTSW |
7 |
3,911,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6480:Lilra6
|
UTSW |
7 |
3,912,933 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6512:Lilra6
|
UTSW |
7 |
3,914,388 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6565:Lilra6
|
UTSW |
7 |
3,915,020 (GRCm38) |
missense |
probably benign |
|
|
R7017:Lilra6
|
UTSW |
7 |
3,908,708 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7095:Lilra6
|
UTSW |
7 |
3,913,197 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7747:Lilra6
|
UTSW |
7 |
3,912,996 (GRCm38) |
missense |
probably benign |
0.16 |
|
R8056:Lilra6
|
UTSW |
7 |
3,912,552 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8280:Lilra6
|
UTSW |
7 |
3,913,047 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9197:Lilra6
|
UTSW |
7 |
3,912,717 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R9354:Lilra6
|
UTSW |
7 |
3,911,629 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9379:Lilra6
|
UTSW |
7 |
3,913,167 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9406:Lilra6
|
UTSW |
7 |
3,914,854 (GRCm38) |
missense |
probably benign |
|
|
R9462:Lilra6
|
UTSW |
7 |
3,911,995 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9649:Lilra6
|
UTSW |
7 |
3,914,522 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
Z1176:Lilra6
|
UTSW |
7 |
3,915,074 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
Z1177:Lilra6
|
UTSW |
7 |
3,912,581 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
| Posted On |
2015-04-16 |
Incidental Mutation