Incidental Mutation 'IGL02587:Gm13178'
ID299570
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm13178
Ensembl Gene ENSMUSG00000041735
Gene Namepredicted gene 13178
Synonyms
Accession Numbers

Ncbi RefSeq: NM_001085536.1; MGI: 3650721

Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #IGL02587
Quality Score
Status
Chromosome4
Chromosomal Location144703191-144721404 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 144703399 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 340 (T340I)
Ref Sequence ENSEMBL: ENSMUSP00000045343 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036876]
Predicted Effect possibly damaging
Transcript: ENSMUST00000036876
AA Change: T340I

PolyPhen 2 Score 0.937 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000045343
Gene: ENSMUSG00000041735
AA Change: T340I

DomainStartEndE-ValueType
transmembrane domain 4 23 N/A INTRINSIC
transmembrane domain 43 60 N/A INTRINSIC
low complexity region 79 84 N/A INTRINSIC
Pfam:Abhydrolase_3 116 286 2.3e-27 PFAM
Pfam:Abhydrolase_3 287 382 8.8e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209924
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(1) : Targeted(1)

Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot10 A T 15: 20,665,797 V286E possibly damaging Het
Bpifa6 T C 2: 153,989,210 L232P probably damaging Het
Calr4 A G 4: 109,238,937 N104S possibly damaging Het
Cdc42bpa A G 1: 180,093,945 E550G possibly damaging Het
D3Ertd751e T A 3: 41,753,852 N141K probably benign Het
Emilin2 A G 17: 71,280,856 probably benign Het
Eml6 T C 11: 29,784,236 E1168G possibly damaging Het
Fbxo48 T C 11: 16,953,659 I95T probably benign Het
Fpr3 A T 17: 17,970,691 T75S probably benign Het
Gm4788 G A 1: 139,701,930 T712I probably damaging Het
Gm5145 A G 17: 20,571,190 K277E probably damaging Het
Gnao1 A G 8: 93,950,439 probably benign Het
Krt8 G A 15: 101,998,932 R239C probably benign Het
Lrrc17 A T 5: 21,561,080 N187Y probably damaging Het
Neil1 C T 9: 57,144,979 R195H probably damaging Het
Nr2f1 C A 13: 78,195,156 probably benign Het
Pi4ka C A 16: 17,317,353 G946W probably damaging Het
Plcg2 A T 8: 117,558,113 N159I possibly damaging Het
Rad54l A G 4: 116,105,797 Y335H probably damaging Het
Rgsl1 C T 1: 153,799,938 R159H probably damaging Het
Scn11a T C 9: 119,805,684 D357G probably damaging Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
Timeless A G 10: 128,239,916 M6V probably damaging Het
Vps16 T C 2: 130,439,716 probably null Het
Zfp955b C A 17: 33,300,650 Q31K probably damaging Het
Other mutations in Gm13178
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00661:Gm13178 APN 4 144703693 missense possibly damaging 0.87
IGL01985:Gm13178 APN 4 144715454 nonsense probably null
P0018:Gm13178 UTSW 4 144703197 missense probably benign 0.00
R0395:Gm13178 UTSW 4 144703195 missense probably benign 0.14
R1617:Gm13178 UTSW 4 144715391 missense probably damaging 1.00
R3802:Gm13178 UTSW 4 144703504 missense possibly damaging 0.82
R4409:Gm13178 UTSW 4 144721302 missense possibly damaging 0.86
R4577:Gm13178 UTSW 4 144703753 missense probably damaging 1.00
R4603:Gm13178 UTSW 4 144703228 missense probably benign 0.00
R5069:Gm13178 UTSW 4 144703867 missense probably damaging 1.00
R5801:Gm13178 UTSW 4 144703636 missense probably damaging 1.00
R5802:Gm13178 UTSW 4 144703636 missense probably damaging 1.00
R5893:Gm13178 UTSW 4 144703196 missense probably benign
R6148:Gm13178 UTSW 4 144721317 missense possibly damaging 0.89
R6466:Gm13178 UTSW 4 144703867 missense probably damaging 1.00
R6655:Gm13178 UTSW 4 144705245 missense probably damaging 1.00
R7006:Gm13178 UTSW 4 144721283 missense probably benign 0.00
R7021:Gm13178 UTSW 4 144715492 missense probably damaging 1.00
R7030:Gm13178 UTSW 4 144703603 missense possibly damaging 0.85
R7514:Gm13178 UTSW 4 144703228 missense possibly damaging 0.66
R7773:Gm13178 UTSW 4 144703477 missense probably damaging 0.98
R7791:Gm13178 UTSW 4 144703445 missense probably damaging 1.00
R8012:Gm13178 UTSW 4 144703402 missense possibly damaging 0.48
Z1176:Gm13178 UTSW 4 144703325 missense probably damaging 1.00
Z1177:Gm13178 UTSW 4 144703646 missense possibly damaging 0.87
Posted On2015-04-16