Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02587:Zfp955b'

299586

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp955b

Ensembl Gene

ENSMUSG00000096910

Gene Name

zinc finger protein 955B

Synonyms

A430003O12Rik, C430039G02Rik, Gm4455

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

IGL02587

Quality Score

Status

Chromosome

Chromosomal Location

33289649-33303196 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 33300650 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Lysine at position 31 (Q31K)

Ref Sequence

ENSEMBL: ENSMUSP00000097011 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099414]

AlphaFold

L7N232

Predicted Effect

probably damaging
Transcript: ENSMUST00000099414
AA Change: Q31K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000097011
Gene: ENSMUSG00000096910
AA Change: Q31K

Domain	Start	End	E-Value	Type
KRAB	10	70	3.04e-14	SMART
ZnF_C2H2	230	252	7.68e0	SMART
ZnF_C2H2	258	280	5.72e-1	SMART
ZnF_C2H2	290	312	6.75e0	SMART
ZnF_C2H2	318	340	5.81e-2	SMART
ZnF_C2H2	346	368	3.16e-3	SMART
ZnF_C2H2	374	396	1.18e-2	SMART
ZnF_C2H2	402	424	7.78e-3	SMART
ZnF_C2H2	430	452	3.16e-3	SMART
ZnF_C2H2	458	480	1.1e-2	SMART
ZnF_C2H2	486	508	2.09e-3	SMART
ZnF_C2H2	514	536	6.67e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000182230

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acot10	A	T	15: 20,665,797	V286E	possibly damaging	Het
Bpifa6	T	C	2: 153,989,210	L232P	probably damaging	Het
Calr4	A	G	4: 109,238,937	N104S	possibly damaging	Het
Cdc42bpa	A	G	1: 180,093,945	E550G	possibly damaging	Het
D3Ertd751e	T	A	3: 41,753,852	N141K	probably benign	Het
Emilin2	A	G	17: 71,280,856		probably benign	Het
Eml6	T	C	11: 29,784,236	E1168G	possibly damaging	Het
Fbxo48	T	C	11: 16,953,659	I95T	probably benign	Het
Fpr3	A	T	17: 17,970,691	T75S	probably benign	Het
Gm13178	G	A	4: 144,703,399	T340I	possibly damaging	Het
Gm4788	G	A	1: 139,701,930	T712I	probably damaging	Het
Gm5145	A	G	17: 20,571,190	K277E	probably damaging	Het
Gnao1	A	G	8: 93,950,439		probably benign	Het
Krt8	G	A	15: 101,998,932	R239C	probably benign	Het
Lrrc17	A	T	5: 21,561,080	N187Y	probably damaging	Het
Neil1	C	T	9: 57,144,979	R195H	probably damaging	Het
Nr2f1	C	A	13: 78,195,156		probably benign	Het
Pi4ka	C	A	16: 17,317,353	G946W	probably damaging	Het
Plcg2	A	T	8: 117,558,113	N159I	possibly damaging	Het
Rad54l	A	G	4: 116,105,797	Y335H	probably damaging	Het
Rgsl1	C	T	1: 153,799,938	R159H	probably damaging	Het
Scn11a	T	C	9: 119,805,684	D357G	probably damaging	Het
Srrm1	G	A	4: 135,325,104	P658L	unknown	Het
Timeless	A	G	10: 128,239,916	M6V	probably damaging	Het
Vps16	T	C	2: 130,439,716		probably null	Het

Other mutations in Zfp955b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00537:Zfp955b	APN	17	33302873	missense	probably damaging	1.00
IGL02073:Zfp955b	APN	17	33300590	missense	possibly damaging	0.69
IGL02126:Zfp955b	APN	17	33302264	nonsense	probably null
IGL02237:Zfp955b	APN	17	33301919	missense	probably damaging	1.00
IGL02971:Zfp955b	APN	17	33300966	missense	probably benign	0.11
IGL03034:Zfp955b	APN	17	33302168	missense	probably benign	0.22
IGL03493:Zfp955b	APN	17	33302545	missense	probably benign	0.35
R0269:Zfp955b	UTSW	17	33305463	missense	probably damaging	1.00
R0373:Zfp955b	UTSW	17	33302522	missense	probably benign
R0617:Zfp955b	UTSW	17	33305463	missense	probably damaging	1.00
R0684:Zfp955b	UTSW	17	33302973	missense	probably benign	0.00
R1778:Zfp955b	UTSW	17	33302814	missense	probably benign	0.07
R1874:Zfp955b	UTSW	17	33305453	missense	probably benign	0.10
R3893:Zfp955b	UTSW	17	33302994	missense	probably benign	0.01
R3938:Zfp955b	UTSW	17	33305416	missense	probably damaging	1.00
R4082:Zfp955b	UTSW	17	33302155	missense	probably benign	0.08
R4672:Zfp955b	UTSW	17	33305259	unclassified	probably benign
R4956:Zfp955b	UTSW	17	33305235	unclassified	probably benign
R4998:Zfp955b	UTSW	17	33305151	unclassified	probably benign
R5276:Zfp955b	UTSW	17	33303057	missense	probably damaging	1.00
R5341:Zfp955b	UTSW	17	33305121	unclassified	probably benign
R5558:Zfp955b	UTSW	17	33302187	missense	possibly damaging	0.88
R6086:Zfp955b	UTSW	17	33302504	missense	probably benign
R6170:Zfp955b	UTSW	17	33302110	missense	probably benign	0.00
R6306:Zfp955b	UTSW	17	33303186	missense	probably benign	0.07
R6519:Zfp955b	UTSW	17	33302077	missense	possibly damaging	0.55
R9286:Zfp955b	UTSW	17	33302709	missense	probably benign	0.04

Posted On

2015-04-16