Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02588:Retnlg'

299595

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Retnlg

Ensembl Gene

ENSMUSG00000022651

Gene Name

resistin like gamma

Synonyms

Fizz3, Relmg, Xcp1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

IGL02588

Quality Score

Status

Chromosome

Chromosomal Location

48872621-48874496 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 48872892 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 11 (T11A)

Ref Sequence

ENSEMBL: ENSMUSP00000070238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065666]

AlphaFold

Q8K426

Predicted Effect

probably benign
Transcript: ENSMUST00000065666
AA Change: T11A

PolyPhen 2 Score 0.070 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000070238
Gene: ENSMUSG00000022651
AA Change: T11A

Domain	Start	End	E-Value	Type
low complexity region	9	21	N/A	INTRINSIC
Pfam:Resistin	29	116	1.6e-38	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap6	G	A	12: 52,886,499	W258*	probably null	Het
Ankmy2	T	C	12: 36,176,686		probably benign	Het
Arhgap26	G	T	18: 38,601,617		probably benign	Het
Aspscr1	A	G	11: 120,677,531	D60G	possibly damaging	Het
Cdh15	C	A	8: 122,856,552	Y31*	probably null	Het
Cnih3	A	G	1: 181,409,704	R76G	probably benign	Het
Cplx1	C	A	5: 108,525,423	R44L	possibly damaging	Het
Dhx57	T	A	17: 80,268,871	I597F	probably damaging	Het
Dnah17	G	T	11: 118,025,653	F4231L	possibly damaging	Het
Dst	T	G	1: 34,117,484	L173R	probably damaging	Het
Fam84b	T	C	15: 60,823,150	D249G	probably damaging	Het
Fezf2	A	T	14: 12,343,687	Y353N	probably damaging	Het
Ghrhr	T	A	6: 55,383,410	L247Q	probably damaging	Het
Gm10912	C	T	2: 104,066,852		probably benign	Het
Gpcpd1	A	T	2: 132,534,753	L541H	probably damaging	Het
Gpld1	C	T	13: 24,943,699	T28I	probably damaging	Het
Lmf2	A	T	15: 89,355,406		probably null	Het
Mex3c	A	G	18: 73,590,045	N403S	probably damaging	Het
Nlrp1b	A	T	11: 71,182,279	L246*	probably null	Het
Nlrp2	A	T	7: 5,327,552	L615*	probably null	Het
Nlrp4c	A	T	7: 6,084,648	D760V	probably benign	Het
Nlrp4g	T	C	9: 124,348,843		noncoding transcript	Het
Nr2f1	C	A	13: 78,195,156		probably benign	Het
Nuggc	T	A	14: 65,617,777		probably benign	Het
Olfr1228	T	C	2: 89,249,698		probably benign	Het
Olfr646	C	T	7: 104,107,053	T258I	possibly damaging	Het
Papolg	T	A	11: 23,890,252	I75F	probably damaging	Het
Pcdhgc5	A	G	18: 37,821,950	Y759C	probably damaging	Het
Pdp2	A	G	8: 104,594,904	K462E	possibly damaging	Het
Plod1	A	T	4: 147,913,290	L654*	probably null	Het
Ppp4r3b	G	T	11: 29,198,853	G25*	probably null	Het
Ptch1	T	C	13: 63,511,918	D1307G	probably benign	Het
Ranbp17	A	G	11: 33,217,361	V1034A	probably benign	Het
Rbl2	T	A	8: 91,087,084	L319Q	probably damaging	Het
Rfc3	A	T	5: 151,642,916	F356Y	possibly damaging	Het
Rnf213	G	T	11: 119,416,536	C674F	probably benign	Het
Shcbp1l	A	G	1: 153,428,665	K157E	probably benign	Het
Slc22a17	A	G	14: 54,907,994	C233R	probably damaging	Het
Slc38a9	A	G	13: 112,697,977		probably null	Het
Srrm1	G	A	4: 135,325,104	P658L	unknown	Het
St14	C	A	9: 31,090,033		probably benign	Het
Sympk	G	A	7: 19,042,625	V481M	probably benign	Het
Timeless	T	A	10: 128,243,334	L350Q	probably damaging	Het
Tnfrsf1a	A	G	6: 125,360,766	I229V	probably benign	Het
Ugt3a2	A	T	15: 9,361,456	H106L	probably benign	Het
Zbtb45	A	T	7: 13,006,277	C470*	probably null	Het

Other mutations in Retnlg

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00985:Retnlg	APN	16	48874325	missense	possibly damaging	0.89
IGL02500:Retnlg	APN	16	48872960	missense	probably benign	0.16
IGL03206:Retnlg	APN	16	48874292	missense	probably damaging	1.00
R1165:Retnlg	UTSW	16	48873654	missense	possibly damaging	0.76
R1751:Retnlg	UTSW	16	48873628	missense	possibly damaging	0.54
R1767:Retnlg	UTSW	16	48873628	missense	possibly damaging	0.54
R1796:Retnlg	UTSW	16	48874247	missense	probably benign	0.06
R2037:Retnlg	UTSW	16	48874252	missense	probably damaging	1.00
R4780:Retnlg	UTSW	16	48874334	missense	possibly damaging	0.74
R7298:Retnlg	UTSW	16	48872874	missense	probably benign
R7983:Retnlg	UTSW	16	48872898	missense	probably damaging	0.98
R8991:Retnlg	UTSW	16	48873675	missense	possibly damaging	0.50
R9140:Retnlg	UTSW	16	48872925	missense	possibly damaging	0.85

Posted On

2015-04-16