Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02588:Nuggc'

299637

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nuggc

Ensembl Gene

ENSMUSG00000061356

Gene Name

nuclear GTPase, germinal center associated

Synonyms

Gm600, SLIP-GC, LOC239151

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

IGL02588

Quality Score

Status

Chromosome

Chromosomal Location

65598546-65648531 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 65617777 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000118402 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079469] [ENSMUST00000150897]

AlphaFold

D3YWJ0

Predicted Effect

probably benign
Transcript: ENSMUST00000079469

SMART Domains

Protein: ENSMUSP00000078434
Gene: ENSMUSG00000061356

Domain	Start	End	E-Value	Type
Pfam:Dynamin_N	119	372	2.2e-15	PFAM
low complexity region	406	421	N/A	INTRINSIC
Blast:AAA	434	739	4e-14	BLAST
coiled coil region	758	792	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000150897

SMART Domains

Protein: ENSMUSP00000118402
Gene: ENSMUSG00000061356

Domain	Start	End	E-Value	Type
Pfam:Dynamin_N	103	356	6.1e-16	PFAM
low complexity region	390	405	N/A	INTRINSIC
Blast:AAA	418	723	4e-14	BLAST
coiled coil region	742	776	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased somatic mutation frequency immunoglobulin and non-immunoglobulin loci in B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap6	G	A	12: 52,886,499	W258*	probably null	Het
Ankmy2	T	C	12: 36,176,686		probably benign	Het
Arhgap26	G	T	18: 38,601,617		probably benign	Het
Aspscr1	A	G	11: 120,677,531	D60G	possibly damaging	Het
Cdh15	C	A	8: 122,856,552	Y31*	probably null	Het
Cnih3	A	G	1: 181,409,704	R76G	probably benign	Het
Cplx1	C	A	5: 108,525,423	R44L	possibly damaging	Het
Dhx57	T	A	17: 80,268,871	I597F	probably damaging	Het
Dnah17	G	T	11: 118,025,653	F4231L	possibly damaging	Het
Dst	T	G	1: 34,117,484	L173R	probably damaging	Het
Fam84b	T	C	15: 60,823,150	D249G	probably damaging	Het
Fezf2	A	T	14: 12,343,687	Y353N	probably damaging	Het
Ghrhr	T	A	6: 55,383,410	L247Q	probably damaging	Het
Gm10912	C	T	2: 104,066,852		probably benign	Het
Gpcpd1	A	T	2: 132,534,753	L541H	probably damaging	Het
Gpld1	C	T	13: 24,943,699	T28I	probably damaging	Het
Lmf2	A	T	15: 89,355,406		probably null	Het
Mex3c	A	G	18: 73,590,045	N403S	probably damaging	Het
Nlrp1b	A	T	11: 71,182,279	L246*	probably null	Het
Nlrp2	A	T	7: 5,327,552	L615*	probably null	Het
Nlrp4c	A	T	7: 6,084,648	D760V	probably benign	Het
Nlrp4g	T	C	9: 124,348,843		noncoding transcript	Het
Nr2f1	C	A	13: 78,195,156		probably benign	Het
Olfr1228	T	C	2: 89,249,698		probably benign	Het
Olfr646	C	T	7: 104,107,053	T258I	possibly damaging	Het
Papolg	T	A	11: 23,890,252	I75F	probably damaging	Het
Pcdhgc5	A	G	18: 37,821,950	Y759C	probably damaging	Het
Pdp2	A	G	8: 104,594,904	K462E	possibly damaging	Het
Plod1	A	T	4: 147,913,290	L654*	probably null	Het
Ppp4r3b	G	T	11: 29,198,853	G25*	probably null	Het
Ptch1	T	C	13: 63,511,918	D1307G	probably benign	Het
Ranbp17	A	G	11: 33,217,361	V1034A	probably benign	Het
Rbl2	T	A	8: 91,087,084	L319Q	probably damaging	Het
Retnlg	A	G	16: 48,872,892	T11A	probably benign	Het
Rfc3	A	T	5: 151,642,916	F356Y	possibly damaging	Het
Rnf213	G	T	11: 119,416,536	C674F	probably benign	Het
Shcbp1l	A	G	1: 153,428,665	K157E	probably benign	Het
Slc22a17	A	G	14: 54,907,994	C233R	probably damaging	Het
Slc38a9	A	G	13: 112,697,977		probably null	Het
Srrm1	G	A	4: 135,325,104	P658L	unknown	Het
St14	C	A	9: 31,090,033		probably benign	Het
Sympk	G	A	7: 19,042,625	V481M	probably benign	Het
Timeless	T	A	10: 128,243,334	L350Q	probably damaging	Het
Tnfrsf1a	A	G	6: 125,360,766	I229V	probably benign	Het
Ugt3a2	A	T	15: 9,361,456	H106L	probably benign	Het
Zbtb45	A	T	7: 13,006,277	C470*	probably null	Het

Other mutations in Nuggc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01359:Nuggc	APN	14	65623207	missense	probably damaging	1.00
IGL01403:Nuggc	APN	14	65623186	missense	probably benign	0.01
IGL01413:Nuggc	APN	14	65638581	missense	probably benign	0.23
R0102:Nuggc	UTSW	14	65613551	missense	probably null	1.00
R0102:Nuggc	UTSW	14	65613551	missense	probably null	1.00
R0395:Nuggc	UTSW	14	65613472	nonsense	probably null
R0827:Nuggc	UTSW	14	65608891	missense	probably damaging	1.00
R1496:Nuggc	UTSW	14	65624133	missense	probably damaging	0.96
R1861:Nuggc	UTSW	14	65642001	splice site	probably benign
R1986:Nuggc	UTSW	14	65641921	missense	probably damaging	0.98
R1995:Nuggc	UTSW	14	65611174	missense	probably benign	0.02
R2283:Nuggc	UTSW	14	65638612	missense	possibly damaging	0.89
R2317:Nuggc	UTSW	14	65624142	missense	possibly damaging	0.81
R3799:Nuggc	UTSW	14	65619638	missense	probably benign	0.00
R3980:Nuggc	UTSW	14	65619093	critical splice donor site	probably null
R4303:Nuggc	UTSW	14	65611172	missense	possibly damaging	0.77
R4431:Nuggc	UTSW	14	65611210	missense	probably benign	0.19
R4734:Nuggc	UTSW	14	65623230	missense	probably damaging	1.00
R5095:Nuggc	UTSW	14	65635090	nonsense	probably null
R5108:Nuggc	UTSW	14	65638680	missense	probably damaging	0.99
R5360:Nuggc	UTSW	14	65638626	missense	probably damaging	1.00
R5547:Nuggc	UTSW	14	65641881	missense	possibly damaging	0.87
R5636:Nuggc	UTSW	14	65648188	nonsense	probably null
R6494:Nuggc	UTSW	14	65648222	missense	probably damaging	1.00
R6922:Nuggc	UTSW	14	65617643	missense	probably damaging	1.00
R6971:Nuggc	UTSW	14	65608856	missense	probably benign	0.04
R7124:Nuggc	UTSW	14	65608802	missense	probably damaging	1.00
R7273:Nuggc	UTSW	14	65619608	missense	probably damaging	0.99
R7282:Nuggc	UTSW	14	65617623	missense	probably damaging	1.00
R7578:Nuggc	UTSW	14	65648174	missense	probably damaging	1.00
R7670:Nuggc	UTSW	14	65613526	missense	probably damaging	1.00
R7780:Nuggc	UTSW	14	65645041	missense	probably damaging	1.00
R7871:Nuggc	UTSW	14	65623251	missense	probably benign	0.01
R8250:Nuggc	UTSW	14	65641869	missense	probably benign	0.10
R8329:Nuggc	UTSW	14	65641282	missense	probably benign	0.01
R8334:Nuggc	UTSW	14	65645029	missense	probably benign	0.04
R8463:Nuggc	UTSW	14	65613562	missense	probably damaging	1.00
R8503:Nuggc	UTSW	14	65641348	critical splice donor site	probably null
R8737:Nuggc	UTSW	14	65645086	missense	probably benign	0.00
R8861:Nuggc	UTSW	14	65610035	critical splice donor site	probably null
R8914:Nuggc	UTSW	14	65641905	missense	probably benign
R9573:Nuggc	UTSW	14	65611154	missense	probably benign	0.37
R9666:Nuggc	UTSW	14	65619596	missense	possibly damaging	0.86
R9792:Nuggc	UTSW	14	65609896	missense	probably damaging	1.00
R9793:Nuggc	UTSW	14	65609896	missense	probably damaging	1.00
R9795:Nuggc	UTSW	14	65609896	missense	probably damaging	1.00
RF019:Nuggc	UTSW	14	65648264	missense	probably damaging	1.00

Posted On

2015-04-16