Incidental Mutation 'IGL02588:Nuggc'
ID 299637
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nuggc
Ensembl Gene ENSMUSG00000061356
Gene Name nuclear GTPase, germinal center associated
Synonyms SLIP-GC, Gm600, LOC239151
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # IGL02588
Quality Score
Status
Chromosome 14
Chromosomal Location 65835995-65885980 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to A at 65855226 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118402 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079469] [ENSMUST00000150897]
AlphaFold D3YWJ0
Predicted Effect probably benign
Transcript: ENSMUST00000079469
SMART Domains Protein: ENSMUSP00000078434
Gene: ENSMUSG00000061356

DomainStartEndE-ValueType
Pfam:Dynamin_N 119 372 2.2e-15 PFAM
low complexity region 406 421 N/A INTRINSIC
Blast:AAA 434 739 4e-14 BLAST
coiled coil region 758 792 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000150897
SMART Domains Protein: ENSMUSP00000118402
Gene: ENSMUSG00000061356

DomainStartEndE-ValueType
Pfam:Dynamin_N 103 356 6.1e-16 PFAM
low complexity region 390 405 N/A INTRINSIC
Blast:AAA 418 723 4e-14 BLAST
coiled coil region 742 776 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased somatic mutation frequency immunoglobulin and non-immunoglobulin loci in B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 G A 12: 52,933,282 (GRCm39) W258* probably null Het
Ankmy2 T C 12: 36,226,685 (GRCm39) probably benign Het
Arhgap26 G T 18: 38,734,670 (GRCm39) probably benign Het
Aspscr1 A G 11: 120,568,357 (GRCm39) D60G possibly damaging Het
Cdh15 C A 8: 123,583,291 (GRCm39) Y31* probably null Het
Cnih3 A G 1: 181,237,269 (GRCm39) R76G probably benign Het
Cplx1 C A 5: 108,673,289 (GRCm39) R44L possibly damaging Het
Dhx57 T A 17: 80,576,300 (GRCm39) I597F probably damaging Het
Dnah17 G T 11: 117,916,479 (GRCm39) F4231L possibly damaging Het
Dst T G 1: 34,156,565 (GRCm39) L173R probably damaging Het
Fezf2 A T 14: 12,343,687 (GRCm38) Y353N probably damaging Het
Ghrhr T A 6: 55,360,395 (GRCm39) L247Q probably damaging Het
Gm10912 C T 2: 103,897,197 (GRCm39) probably benign Het
Gpcpd1 A T 2: 132,376,673 (GRCm39) L541H probably damaging Het
Gpld1 C T 13: 25,127,682 (GRCm39) T28I probably damaging Het
Lmf2 A T 15: 89,239,609 (GRCm39) probably null Het
Lratd2 T C 15: 60,694,999 (GRCm39) D249G probably damaging Het
Mex3c A G 18: 73,723,116 (GRCm39) N403S probably damaging Het
Nlrp1b A T 11: 71,073,105 (GRCm39) L246* probably null Het
Nlrp2 A T 7: 5,330,551 (GRCm39) L615* probably null Het
Nlrp4c A T 7: 6,087,647 (GRCm39) D760V probably benign Het
Nlrp4g T C 9: 124,348,843 (GRCm38) noncoding transcript Het
Nr2f1 C A 13: 78,343,275 (GRCm39) probably benign Het
Or4c122 T C 2: 89,080,042 (GRCm39) probably benign Het
Or52d1 C T 7: 103,756,260 (GRCm39) T258I possibly damaging Het
Papolg T A 11: 23,840,252 (GRCm39) I75F probably damaging Het
Pcdhgc5 A G 18: 37,955,003 (GRCm39) Y759C probably damaging Het
Pdp2 A G 8: 105,321,536 (GRCm39) K462E possibly damaging Het
Plod1 A T 4: 147,997,747 (GRCm39) L654* probably null Het
Ppp4r3b G T 11: 29,148,853 (GRCm39) G25* probably null Het
Ptch1 T C 13: 63,659,732 (GRCm39) D1307G probably benign Het
Ranbp17 A G 11: 33,167,361 (GRCm39) V1034A probably benign Het
Rbl2 T A 8: 91,813,712 (GRCm39) L319Q probably damaging Het
Retnlg A G 16: 48,693,255 (GRCm39) T11A probably benign Het
Rfc3 A T 5: 151,566,381 (GRCm39) F356Y possibly damaging Het
Rnf213 G T 11: 119,307,362 (GRCm39) C674F probably benign Het
Shcbp1l A G 1: 153,304,411 (GRCm39) K157E probably benign Het
Slc22a17 A G 14: 55,145,451 (GRCm39) C233R probably damaging Het
Slc38a9 A G 13: 112,834,511 (GRCm39) probably null Het
Srrm1 G A 4: 135,052,415 (GRCm39) P658L unknown Het
St14 C A 9: 31,001,329 (GRCm39) probably benign Het
Sympk G A 7: 18,776,550 (GRCm39) V481M probably benign Het
Timeless T A 10: 128,079,203 (GRCm39) L350Q probably damaging Het
Tnfrsf1a A G 6: 125,337,729 (GRCm39) I229V probably benign Het
Ugt3a1 A T 15: 9,361,542 (GRCm39) H106L probably benign Het
Zbtb45 A T 7: 12,740,204 (GRCm39) C470* probably null Het
Other mutations in Nuggc
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01359:Nuggc APN 14 65,860,656 (GRCm39) missense probably damaging 1.00
IGL01403:Nuggc APN 14 65,860,635 (GRCm39) missense probably benign 0.01
IGL01413:Nuggc APN 14 65,876,030 (GRCm39) missense probably benign 0.23
R0102:Nuggc UTSW 14 65,851,000 (GRCm39) missense probably null 1.00
R0102:Nuggc UTSW 14 65,851,000 (GRCm39) missense probably null 1.00
R0395:Nuggc UTSW 14 65,850,921 (GRCm39) nonsense probably null
R0827:Nuggc UTSW 14 65,846,340 (GRCm39) missense probably damaging 1.00
R1496:Nuggc UTSW 14 65,861,582 (GRCm39) missense probably damaging 0.96
R1861:Nuggc UTSW 14 65,879,450 (GRCm39) splice site probably benign
R1986:Nuggc UTSW 14 65,879,370 (GRCm39) missense probably damaging 0.98
R1995:Nuggc UTSW 14 65,848,623 (GRCm39) missense probably benign 0.02
R2283:Nuggc UTSW 14 65,876,061 (GRCm39) missense possibly damaging 0.89
R2317:Nuggc UTSW 14 65,861,591 (GRCm39) missense possibly damaging 0.81
R3799:Nuggc UTSW 14 65,857,087 (GRCm39) missense probably benign 0.00
R3980:Nuggc UTSW 14 65,856,542 (GRCm39) critical splice donor site probably null
R4303:Nuggc UTSW 14 65,848,621 (GRCm39) missense possibly damaging 0.77
R4431:Nuggc UTSW 14 65,848,659 (GRCm39) missense probably benign 0.19
R4734:Nuggc UTSW 14 65,860,679 (GRCm39) missense probably damaging 1.00
R5095:Nuggc UTSW 14 65,872,539 (GRCm39) nonsense probably null
R5108:Nuggc UTSW 14 65,876,129 (GRCm39) missense probably damaging 0.99
R5360:Nuggc UTSW 14 65,876,075 (GRCm39) missense probably damaging 1.00
R5547:Nuggc UTSW 14 65,879,330 (GRCm39) missense possibly damaging 0.87
R5636:Nuggc UTSW 14 65,885,637 (GRCm39) nonsense probably null
R6494:Nuggc UTSW 14 65,885,671 (GRCm39) missense probably damaging 1.00
R6922:Nuggc UTSW 14 65,855,092 (GRCm39) missense probably damaging 1.00
R6971:Nuggc UTSW 14 65,846,305 (GRCm39) missense probably benign 0.04
R7124:Nuggc UTSW 14 65,846,251 (GRCm39) missense probably damaging 1.00
R7273:Nuggc UTSW 14 65,857,057 (GRCm39) missense probably damaging 0.99
R7282:Nuggc UTSW 14 65,855,072 (GRCm39) missense probably damaging 1.00
R7578:Nuggc UTSW 14 65,885,623 (GRCm39) missense probably damaging 1.00
R7670:Nuggc UTSW 14 65,850,975 (GRCm39) missense probably damaging 1.00
R7780:Nuggc UTSW 14 65,882,490 (GRCm39) missense probably damaging 1.00
R7871:Nuggc UTSW 14 65,860,700 (GRCm39) missense probably benign 0.01
R8250:Nuggc UTSW 14 65,879,318 (GRCm39) missense probably benign 0.10
R8329:Nuggc UTSW 14 65,878,731 (GRCm39) missense probably benign 0.01
R8334:Nuggc UTSW 14 65,882,478 (GRCm39) missense probably benign 0.04
R8463:Nuggc UTSW 14 65,851,011 (GRCm39) missense probably damaging 1.00
R8503:Nuggc UTSW 14 65,878,797 (GRCm39) critical splice donor site probably null
R8737:Nuggc UTSW 14 65,882,535 (GRCm39) missense probably benign 0.00
R8861:Nuggc UTSW 14 65,847,484 (GRCm39) critical splice donor site probably null
R8914:Nuggc UTSW 14 65,879,354 (GRCm39) missense probably benign
R9573:Nuggc UTSW 14 65,848,603 (GRCm39) missense probably benign 0.37
R9666:Nuggc UTSW 14 65,857,045 (GRCm39) missense possibly damaging 0.86
R9792:Nuggc UTSW 14 65,847,345 (GRCm39) missense probably damaging 1.00
R9793:Nuggc UTSW 14 65,847,345 (GRCm39) missense probably damaging 1.00
R9795:Nuggc UTSW 14 65,847,345 (GRCm39) missense probably damaging 1.00
RF019:Nuggc UTSW 14 65,885,713 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16