Incidental Mutation 'IGL02588:Ankmy2'
ID299639
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ankmy2
Ensembl Gene ENSMUSG00000036188
Gene Nameankyrin repeat and MYND domain containing 2
Synonyms
Accession Numbers

Genbank: NM_146033; MGI: 2144755

Is this an essential gene? Possibly essential (E-score: 0.537) question?
Stock #IGL02588
Quality Score
Status
Chromosome12
Chromosomal Location36157114-36197291 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to C at 36176686 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000039484 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041640]
Predicted Effect probably benign
Transcript: ENSMUST00000041640
SMART Domains Protein: ENSMUSP00000039484
Gene: ENSMUSG00000036188

DomainStartEndE-ValueType
ANK 45 74 1.1e-6 SMART
ANK 79 108 7.83e-3 SMART
ANK 112 143 9.33e2 SMART
Pfam:zf-MYND 320 357 6.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220580
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220788
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221263
Coding Region Coverage
Validation Efficiency
Allele List at MGI

All alleles(3) : Gene trapped(3)

Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap6 G A 12: 52,886,499 W258* probably null Het
Arhgap26 G T 18: 38,601,617 probably benign Het
Aspscr1 A G 11: 120,677,531 D60G possibly damaging Het
Cdh15 C A 8: 122,856,552 Y31* probably null Het
Cnih3 A G 1: 181,409,704 R76G probably benign Het
Cplx1 C A 5: 108,525,423 R44L possibly damaging Het
Dhx57 T A 17: 80,268,871 I597F probably damaging Het
Dnah17 G T 11: 118,025,653 F4231L possibly damaging Het
Dst T G 1: 34,117,484 L173R probably damaging Het
Fam84b T C 15: 60,823,150 D249G probably damaging Het
Fezf2 A T 14: 12,343,687 Y353N probably damaging Het
Ghrhr T A 6: 55,383,410 L247Q probably damaging Het
Gm10912 C T 2: 104,066,852 probably benign Het
Gpcpd1 A T 2: 132,534,753 L541H probably damaging Het
Gpld1 C T 13: 24,943,699 T28I probably damaging Het
Lmf2 A T 15: 89,355,406 probably null Het
Mex3c A G 18: 73,590,045 N403S probably damaging Het
Nlrp1b A T 11: 71,182,279 L246* probably null Het
Nlrp2 A T 7: 5,327,552 L615* probably null Het
Nlrp4c A T 7: 6,084,648 D760V probably benign Het
Nlrp4g T C 9: 124,348,843 noncoding transcript Het
Nr2f1 C A 13: 78,195,156 probably benign Het
Nuggc T A 14: 65,617,777 probably benign Het
Olfr1228 T C 2: 89,249,698 probably benign Het
Olfr646 C T 7: 104,107,053 T258I possibly damaging Het
Papolg T A 11: 23,890,252 I75F probably damaging Het
Pcdhgc5 A G 18: 37,821,950 Y759C probably damaging Het
Pdp2 A G 8: 104,594,904 K462E possibly damaging Het
Plod1 A T 4: 147,913,290 L654* probably null Het
Ppp4r3b G T 11: 29,198,853 G25* probably null Het
Ptch1 T C 13: 63,511,918 D1307G probably benign Het
Ranbp17 A G 11: 33,217,361 V1034A probably benign Het
Rbl2 T A 8: 91,087,084 L319Q probably damaging Het
Retnlg A G 16: 48,872,892 T11A probably benign Het
Rfc3 A T 5: 151,642,916 F356Y possibly damaging Het
Rnf213 G T 11: 119,416,536 C674F probably benign Het
Shcbp1l A G 1: 153,428,665 K157E probably benign Het
Slc22a17 A G 14: 54,907,994 C233R probably damaging Het
Slc38a9 A G 13: 112,697,977 probably null Het
Srrm1 G A 4: 135,325,104 P658L unknown Het
St14 C A 9: 31,090,033 probably benign Het
Sympk G A 7: 19,042,625 V481M probably benign Het
Timeless T A 10: 128,243,334 L350Q probably damaging Het
Tnfrsf1a A G 6: 125,360,766 I229V probably benign Het
Ugt3a2 A T 15: 9,361,456 H106L probably benign Het
Zbtb45 A T 7: 13,006,277 C470* probably null Het
Other mutations in Ankmy2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01971:Ankmy2 APN 12 36193793 nonsense probably null
IGL02975:Ankmy2 APN 12 36193774 missense possibly damaging 0.50
IGL03076:Ankmy2 APN 12 36165918 missense probably damaging 0.98
7510:Ankmy2 UTSW 12 36157412 missense probably benign 0.06
PIT4520001:Ankmy2 UTSW 12 36157391 missense probably benign 0.41
R0135:Ankmy2 UTSW 12 36170435 splice site probably benign
R0319:Ankmy2 UTSW 12 36165899 missense possibly damaging 0.76
R0347:Ankmy2 UTSW 12 36193754 missense probably damaging 1.00
R0485:Ankmy2 UTSW 12 36182390 missense possibly damaging 0.94
R0557:Ankmy2 UTSW 12 36187766 missense probably benign 0.38
R1304:Ankmy2 UTSW 12 36186805 missense probably damaging 0.99
R1397:Ankmy2 UTSW 12 36170441 splice site probably benign
R1572:Ankmy2 UTSW 12 36186942 critical splice donor site probably null
R1674:Ankmy2 UTSW 12 36187669 missense probably benign
R1874:Ankmy2 UTSW 12 36165931 missense possibly damaging 0.77
R1887:Ankmy2 UTSW 12 36170468 missense possibly damaging 0.71
R1985:Ankmy2 UTSW 12 36157364 missense possibly damaging 0.86
R1996:Ankmy2 UTSW 12 36193797 missense probably benign 0.00
R4964:Ankmy2 UTSW 12 36186918 missense possibly damaging 0.69
R5534:Ankmy2 UTSW 12 36182492 missense probably damaging 0.96
R5606:Ankmy2 UTSW 12 36165921 missense probably benign 0.19
R5614:Ankmy2 UTSW 12 36193784 missense probably damaging 1.00
R5906:Ankmy2 UTSW 12 36176633 missense probably damaging 1.00
R6427:Ankmy2 UTSW 12 36187711 missense possibly damaging 0.49
R7065:Ankmy2 UTSW 12 36187708 missense probably damaging 0.96
R7135:Ankmy2 UTSW 12 36196312 missense probably benign
R7705:Ankmy2 UTSW 12 36195108 missense probably benign 0.37
R7721:Ankmy2 UTSW 12 36157144 unclassified probably benign
Z1176:Ankmy2 UTSW 12 36186859 missense probably damaging 0.97
Posted On2015-04-16