Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02589:Vmn2r53'

299668

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r53

Ensembl Gene

ENSMUSG00000096002

Gene Name

vomeronasal 2, receptor 53

Synonyms

EG637908

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02589

Quality Score

Status

Chromosome

Chromosomal Location

12581470-12606544 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 12581945 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 649 (T649I)

Ref Sequence

ENSEMBL: ENSMUSP00000126979 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170412]

AlphaFold

A0A3B2W4A7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170412
AA Change: T649I

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: T649I

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	5	397	3.6e-58	PFAM
Pfam:NCD3G	442	495	2.2e-19	PFAM
Pfam:7tm_3	526	763	3.1e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410015M20Rik	T	C	17: 56,608,856	E66G	probably benign	Het
5430403G16Rik	T	A	5: 109,678,520	H62L	possibly damaging	Het
A2ml1	T	G	6: 128,581,500	I5L	probably benign	Het
Ang6	A	G	14: 44,001,962	I103T	possibly damaging	Het
Arhgdib	A	G	6: 136,933,578		probably benign	Het
Atp13a2	C	T	4: 141,006,411	T1037M	probably damaging	Het
Bptf	T	C	11: 107,111,531	N252D	possibly damaging	Het
Capn2	T	C	1: 182,484,348	Y387C	probably damaging	Het
Cdc27	T	G	11: 104,505,644	D817A	probably benign	Het
Cdc45	C	T	16: 18,798,729	M200I	probably benign	Het
Cntnap3	T	G	13: 64,792,430	I318L	probably benign	Het
Cog6	A	T	3: 53,007,270	L255Q	probably damaging	Het
Ect2l	T	A	10: 18,140,594		probably benign	Het
Ercc5	T	C	1: 44,164,049	V282A	probably damaging	Het
Fras1	A	G	5: 96,769,513	D3464G	probably damaging	Het
Gabrg1	A	T	5: 70,842,152	L18*	probably null	Het
Ggcx	T	C	6: 72,429,148	Y586H	probably damaging	Het
Gm5796	A	T	14: 4,033,828	K24*	probably null	Het
Gnb4	C	T	3: 32,589,849	V187M	probably damaging	Het
Gpt2	C	T	8: 85,516,166	Q276*	probably null	Het
Idnk	G	T	13: 58,163,425		probably benign	Het
Igkv3-9	A	G	6: 70,588,699	D94G	possibly damaging	Het
Ipo8	C	A	6: 148,809,907	L294F	probably damaging	Het
Itgad	A	T	7: 128,181,711	D157V	probably damaging	Het
Kcnab3	A	T	11: 69,332,102	I392L	probably benign	Het
Kdm3b	A	G	18: 34,812,418	S761G	possibly damaging	Het
Kif21a	G	A	15: 90,985,286	T454M	probably damaging	Het
Lta4h	A	G	10: 93,474,931	N441S	probably benign	Het
Man2a1	A	G	17: 64,679,778	E595G	probably benign	Het
Mvd	T	C	8: 122,438,034		probably benign	Het
Notch2	A	G	3: 98,104,347		probably null	Het
Phf20l1	G	T	15: 66,615,632		probably benign	Het
Rdm1	A	G	11: 101,628,005	S13G	possibly damaging	Het
Rnf123	G	A	9: 108,068,302	R390*	probably null	Het
Scn4a	G	T	11: 106,328,132	D953E	probably benign	Het
Sh2b1	A	G	7: 126,469,268	I457T	probably benign	Het
Srrm1	G	A	4: 135,325,104	P658L	unknown	Het
Tagap	C	A	17: 7,933,672	T563K	possibly damaging	Het
Ugt1a7c	T	C	1: 88,095,638	I173T	probably benign	Het
Unc79	C	T	12: 103,173,496	A2370V	probably damaging	Het
Vmn2r102	T	A	17: 19,681,218	C536S	probably damaging	Het
Whrn	G	A	4: 63,418,097	Q301*	probably null	Het
Zfp518a	G	A	19: 40,914,617	G997R	probably damaging	Het

Other mutations in Vmn2r53

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01090:Vmn2r53	APN	7	12600908	missense	possibly damaging	0.70
IGL01997:Vmn2r53	APN	7	12582446	missense	possibly damaging	0.54
IGL02442:Vmn2r53	APN	7	12581729	missense	probably damaging	1.00
IGL02449:Vmn2r53	APN	7	12582361	missense	probably damaging	1.00
IGL02986:Vmn2r53	APN	7	12581466	unclassified	probably benign
IGL03064:Vmn2r53	APN	7	12601010	missense	possibly damaging	0.89
IGL03093:Vmn2r53	APN	7	12600864	missense	probably benign	0.03
IGL03244:Vmn2r53	APN	7	12606508	missense	probably damaging	1.00
IGL03252:Vmn2r53	APN	7	12606391	missense	probably damaging	1.00
IGL03264:Vmn2r53	APN	7	12581892	missense	possibly damaging	0.95
IGL03293:Vmn2r53	APN	7	12598422	missense	probably benign	0.34
R0109:Vmn2r53	UTSW	7	12582066	missense	probably damaging	1.00
R0453:Vmn2r53	UTSW	7	12582411	missense	probably damaging	1.00
R0735:Vmn2r53	UTSW	7	12581780	missense	probably benign
R0881:Vmn2r53	UTSW	7	12600932	missense	probably benign	0.01
R0894:Vmn2r53	UTSW	7	12601214	missense	probably benign	0.00
R0973:Vmn2r53	UTSW	7	12601392	missense	probably damaging	1.00
R0973:Vmn2r53	UTSW	7	12601392	missense	probably damaging	1.00
R0974:Vmn2r53	UTSW	7	12601392	missense	probably damaging	1.00
R0990:Vmn2r53	UTSW	7	12581502	missense	probably benign
R1102:Vmn2r53	UTSW	7	12598483	missense	possibly damaging	0.94
R1141:Vmn2r53	UTSW	7	12600746	missense	possibly damaging	0.54
R1263:Vmn2r53	UTSW	7	12581606	missense	probably benign	0.41
R1343:Vmn2r53	UTSW	7	12584774	missense	probably benign	0.08
R1750:Vmn2r53	UTSW	7	12581705	missense	probably damaging	1.00
R1836:Vmn2r53	UTSW	7	12600885	missense	probably damaging	1.00
R2035:Vmn2r53	UTSW	7	12598511	missense	possibly damaging	0.76
R2202:Vmn2r53	UTSW	7	12601439	missense	probably damaging	1.00
R3707:Vmn2r53	UTSW	7	12582054	missense	possibly damaging	0.95
R4372:Vmn2r53	UTSW	7	12581729	missense	probably damaging	0.98
R4615:Vmn2r53	UTSW	7	12582302	missense	probably damaging	1.00
R4655:Vmn2r53	UTSW	7	12582005	missense	possibly damaging	0.83
R4663:Vmn2r53	UTSW	7	12600974	missense	probably benign	0.21
R4708:Vmn2r53	UTSW	7	12601202	missense	probably benign
R4710:Vmn2r53	UTSW	7	12601202	missense	probably benign
R4774:Vmn2r53	UTSW	7	12600765	nonsense	probably null
R4859:Vmn2r53	UTSW	7	12601403	missense	probably damaging	1.00
R5061:Vmn2r53	UTSW	7	12581814	missense	probably benign	0.01
R5561:Vmn2r53	UTSW	7	12601420	missense	probably damaging	1.00
R5729:Vmn2r53	UTSW	7	12600806	missense	probably damaging	1.00
R6004:Vmn2r53	UTSW	7	12582401	missense	probably benign	0.12
R6083:Vmn2r53	UTSW	7	12581881	missense	probably benign
R6312:Vmn2r53	UTSW	7	12598639	critical splice acceptor site	probably null
R6700:Vmn2r53	UTSW	7	12581706	missense	probably damaging	0.96
R6783:Vmn2r53	UTSW	7	12601433	missense	probably damaging	1.00
R6852:Vmn2r53	UTSW	7	12606514	missense	probably damaging	0.99
R6889:Vmn2r53	UTSW	7	12601142	missense	probably benign	0.10
R6940:Vmn2r53	UTSW	7	12582416	missense	probably benign	0.19
R7100:Vmn2r53	UTSW	7	12581586	nonsense	probably null
R7174:Vmn2r53	UTSW	7	12581701	missense	probably benign	0.01
R7213:Vmn2r53	UTSW	7	12601056	missense	probably benign	0.17
R7276:Vmn2r53	UTSW	7	12606432	missense	probably damaging	0.99
R7515:Vmn2r53	UTSW	7	12581919	missense	probably benign	0.05
R7678:Vmn2r53	UTSW	7	12598498	missense	probably benign	0.04
R7714:Vmn2r53	UTSW	7	12606491	missense	probably damaging	1.00
R7843:Vmn2r53	UTSW	7	12582099	missense	probably damaging	1.00
R8208:Vmn2r53	UTSW	7	12601395	missense	probably damaging	1.00
R8211:Vmn2r53	UTSW	7	12581916	missense	probably benign	0.01
R8478:Vmn2r53	UTSW	7	12606354	missense	probably benign	0.01
R8853:Vmn2r53	UTSW	7	12581810	missense	probably damaging	1.00
R8924:Vmn2r53	UTSW	7	12600825	missense	probably benign	0.17
R8963:Vmn2r53	UTSW	7	12581999	missense	probably damaging	1.00
R9042:Vmn2r53	UTSW	7	12581508	missense	probably benign
R9076:Vmn2r53	UTSW	7	12606304	missense	probably damaging	1.00
R9407:Vmn2r53	UTSW	7	12601197	missense	probably damaging	0.99
R9690:Vmn2r53	UTSW	7	12581985	missense	probably damaging	1.00
Z1176:Vmn2r53	UTSW	7	12601304	missense	probably damaging	1.00

Posted On

2015-04-16