Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02589:Vmn2r53'

299668

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r53

Ensembl Gene

ENSMUSG00000096002

Gene Name

vomeronasal 2, receptor 53

Synonyms

EG637908

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

IGL02589

Quality Score

Status

Chromosome

Chromosomal Location

12315397-12342583 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 12315872 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 649 (T649I)

Ref Sequence

ENSEMBL: ENSMUSP00000126979 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170412]

AlphaFold

A0A3B2W4A7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000170412
AA Change: T649I

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: T649I

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	5	397	3.6e-58	PFAM
Pfam:NCD3G	442	495	2.2e-19	PFAM
Pfam:7tm_3	526	763	3.1e-53	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	T	G	6: 128,558,463 (GRCm39)	I5L	probably benign	Het
Ang6	A	G	14: 44,239,419 (GRCm39)	I103T	possibly damaging	Het
Arhgdib	A	G	6: 136,910,576 (GRCm39)		probably benign	Het
Atp13a2	C	T	4: 140,733,722 (GRCm39)	T1037M	probably damaging	Het
Bptf	T	C	11: 107,002,357 (GRCm39)	N252D	possibly damaging	Het
Capn2	T	C	1: 182,311,913 (GRCm39)	Y387C	probably damaging	Het
Cdc27	T	G	11: 104,396,470 (GRCm39)	D817A	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cntnap3	T	G	13: 64,940,244 (GRCm39)	I318L	probably benign	Het
Cog6	A	T	3: 52,914,691 (GRCm39)	L255Q	probably damaging	Het
Ect2l	T	A	10: 18,016,342 (GRCm39)		probably benign	Het
Ercc5	T	C	1: 44,203,209 (GRCm39)	V282A	probably damaging	Het
Fras1	A	G	5: 96,917,372 (GRCm39)	D3464G	probably damaging	Het
Gabrg1	A	T	5: 70,999,495 (GRCm39)	L18*	probably null	Het
Ggcx	T	C	6: 72,406,131 (GRCm39)	Y586H	probably damaging	Het
Gm5796	A	T	14: 15,379,030 (GRCm39)	K24*	probably null	Het
Gnb4	C	T	3: 32,643,998 (GRCm39)	V187M	probably damaging	Het
Gpt2	C	T	8: 86,242,795 (GRCm39)	Q276*	probably null	Het
Idnk	G	T	13: 58,311,239 (GRCm39)		probably benign	Het
Igkv3-9	A	G	6: 70,565,683 (GRCm39)	D94G	possibly damaging	Het
Ipo8	C	A	6: 148,711,405 (GRCm39)	L294F	probably damaging	Het
Itgad	A	T	7: 127,780,883 (GRCm39)	D157V	probably damaging	Het
Kcnab3	A	T	11: 69,222,928 (GRCm39)	I392L	probably benign	Het
Kdm3b	A	G	18: 34,945,471 (GRCm39)	S761G	possibly damaging	Het
Kif21a	G	A	15: 90,869,489 (GRCm39)	T454M	probably damaging	Het
Lta4h	A	G	10: 93,310,793 (GRCm39)	N441S	probably benign	Het
Man2a1	A	G	17: 64,986,773 (GRCm39)	E595G	probably benign	Het
Micos13	T	C	17: 56,915,856 (GRCm39)	E66G	probably benign	Het
Mvd	T	C	8: 123,164,773 (GRCm39)		probably benign	Het
Notch2	A	G	3: 98,011,663 (GRCm39)		probably null	Het
Phf20l1	G	T	15: 66,487,481 (GRCm39)		probably benign	Het
Rdm1	A	G	11: 101,518,831 (GRCm39)	S13G	possibly damaging	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Scn4a	G	T	11: 106,218,958 (GRCm39)	D953E	probably benign	Het
Sh2b1	A	G	7: 126,068,440 (GRCm39)	I457T	probably benign	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tagap	C	A	17: 8,152,504 (GRCm39)	T563K	possibly damaging	Het
Ugt1a7c	T	C	1: 88,023,360 (GRCm39)	I173T	probably benign	Het
Unc79	C	T	12: 103,139,755 (GRCm39)	A2370V	probably damaging	Het
Vmn2r102	T	A	17: 19,901,480 (GRCm39)	C536S	probably damaging	Het
Whrn	G	A	4: 63,336,334 (GRCm39)	Q301*	probably null	Het
Zfp1007	T	A	5: 109,826,386 (GRCm39)	H62L	possibly damaging	Het
Zfp518a	G	A	19: 40,903,061 (GRCm39)	G997R	probably damaging	Het

Other mutations in Vmn2r53

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01090:Vmn2r53	APN	7	12,334,835 (GRCm39)	missense	possibly damaging	0.70
IGL01997:Vmn2r53	APN	7	12,316,373 (GRCm39)	missense	possibly damaging	0.54
IGL02442:Vmn2r53	APN	7	12,315,656 (GRCm39)	missense	probably damaging	1.00
IGL02449:Vmn2r53	APN	7	12,316,288 (GRCm39)	missense	probably damaging	1.00
IGL02986:Vmn2r53	APN	7	12,315,393 (GRCm39)	unclassified	probably benign
IGL03064:Vmn2r53	APN	7	12,334,937 (GRCm39)	missense	possibly damaging	0.89
IGL03093:Vmn2r53	APN	7	12,334,791 (GRCm39)	missense	probably benign	0.03
IGL03244:Vmn2r53	APN	7	12,340,435 (GRCm39)	missense	probably damaging	1.00
IGL03252:Vmn2r53	APN	7	12,340,318 (GRCm39)	missense	probably damaging	1.00
IGL03264:Vmn2r53	APN	7	12,315,819 (GRCm39)	missense	possibly damaging	0.95
IGL03293:Vmn2r53	APN	7	12,332,349 (GRCm39)	missense	probably benign	0.34
R0109:Vmn2r53	UTSW	7	12,315,993 (GRCm39)	missense	probably damaging	1.00
R0453:Vmn2r53	UTSW	7	12,316,338 (GRCm39)	missense	probably damaging	1.00
R0735:Vmn2r53	UTSW	7	12,315,707 (GRCm39)	missense	probably benign
R0881:Vmn2r53	UTSW	7	12,334,859 (GRCm39)	missense	probably benign	0.01
R0894:Vmn2r53	UTSW	7	12,335,141 (GRCm39)	missense	probably benign	0.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0973:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0974:Vmn2r53	UTSW	7	12,335,319 (GRCm39)	missense	probably damaging	1.00
R0990:Vmn2r53	UTSW	7	12,315,429 (GRCm39)	missense	probably benign
R1102:Vmn2r53	UTSW	7	12,332,410 (GRCm39)	missense	possibly damaging	0.94
R1141:Vmn2r53	UTSW	7	12,334,673 (GRCm39)	missense	possibly damaging	0.54
R1263:Vmn2r53	UTSW	7	12,315,533 (GRCm39)	missense	probably benign	0.41
R1343:Vmn2r53	UTSW	7	12,318,701 (GRCm39)	missense	probably benign	0.08
R1750:Vmn2r53	UTSW	7	12,315,632 (GRCm39)	missense	probably damaging	1.00
R1836:Vmn2r53	UTSW	7	12,334,812 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r53	UTSW	7	12,332,438 (GRCm39)	missense	possibly damaging	0.76
R2202:Vmn2r53	UTSW	7	12,335,366 (GRCm39)	missense	probably damaging	1.00
R3707:Vmn2r53	UTSW	7	12,315,981 (GRCm39)	missense	possibly damaging	0.95
R4372:Vmn2r53	UTSW	7	12,315,656 (GRCm39)	missense	probably damaging	0.98
R4615:Vmn2r53	UTSW	7	12,316,229 (GRCm39)	missense	probably damaging	1.00
R4655:Vmn2r53	UTSW	7	12,315,932 (GRCm39)	missense	possibly damaging	0.83
R4663:Vmn2r53	UTSW	7	12,334,901 (GRCm39)	missense	probably benign	0.21
R4708:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4710:Vmn2r53	UTSW	7	12,335,129 (GRCm39)	missense	probably benign
R4774:Vmn2r53	UTSW	7	12,334,692 (GRCm39)	nonsense	probably null
R4859:Vmn2r53	UTSW	7	12,335,330 (GRCm39)	missense	probably damaging	1.00
R5061:Vmn2r53	UTSW	7	12,315,741 (GRCm39)	missense	probably benign	0.01
R5561:Vmn2r53	UTSW	7	12,335,347 (GRCm39)	missense	probably damaging	1.00
R5729:Vmn2r53	UTSW	7	12,334,733 (GRCm39)	missense	probably damaging	1.00
R6004:Vmn2r53	UTSW	7	12,316,328 (GRCm39)	missense	probably benign	0.12
R6083:Vmn2r53	UTSW	7	12,315,808 (GRCm39)	missense	probably benign
R6312:Vmn2r53	UTSW	7	12,332,566 (GRCm39)	critical splice acceptor site	probably null
R6700:Vmn2r53	UTSW	7	12,315,633 (GRCm39)	missense	probably damaging	0.96
R6783:Vmn2r53	UTSW	7	12,335,360 (GRCm39)	missense	probably damaging	1.00
R6852:Vmn2r53	UTSW	7	12,340,441 (GRCm39)	missense	probably damaging	0.99
R6889:Vmn2r53	UTSW	7	12,335,069 (GRCm39)	missense	probably benign	0.10
R6940:Vmn2r53	UTSW	7	12,316,343 (GRCm39)	missense	probably benign	0.19
R7100:Vmn2r53	UTSW	7	12,315,513 (GRCm39)	nonsense	probably null
R7174:Vmn2r53	UTSW	7	12,315,628 (GRCm39)	missense	probably benign	0.01
R7213:Vmn2r53	UTSW	7	12,334,983 (GRCm39)	missense	probably benign	0.17
R7276:Vmn2r53	UTSW	7	12,340,359 (GRCm39)	missense	probably damaging	0.99
R7515:Vmn2r53	UTSW	7	12,315,846 (GRCm39)	missense	probably benign	0.05
R7678:Vmn2r53	UTSW	7	12,332,425 (GRCm39)	missense	probably benign	0.04
R7714:Vmn2r53	UTSW	7	12,340,418 (GRCm39)	missense	probably damaging	1.00
R7843:Vmn2r53	UTSW	7	12,316,026 (GRCm39)	missense	probably damaging	1.00
R8208:Vmn2r53	UTSW	7	12,335,322 (GRCm39)	missense	probably damaging	1.00
R8211:Vmn2r53	UTSW	7	12,315,843 (GRCm39)	missense	probably benign	0.01
R8478:Vmn2r53	UTSW	7	12,340,281 (GRCm39)	missense	probably benign	0.01
R8853:Vmn2r53	UTSW	7	12,315,737 (GRCm39)	missense	probably damaging	1.00
R8924:Vmn2r53	UTSW	7	12,334,752 (GRCm39)	missense	probably benign	0.17
R8963:Vmn2r53	UTSW	7	12,315,926 (GRCm39)	missense	probably damaging	1.00
R9042:Vmn2r53	UTSW	7	12,315,435 (GRCm39)	missense	probably benign
R9076:Vmn2r53	UTSW	7	12,340,231 (GRCm39)	missense	probably damaging	1.00
R9407:Vmn2r53	UTSW	7	12,335,124 (GRCm39)	missense	probably damaging	0.99
R9690:Vmn2r53	UTSW	7	12,315,912 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r53	UTSW	7	12,335,231 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-04-16