Incidental Mutation 'IGL02591:Or5g25'
ID 299727
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5g25
Ensembl Gene ENSMUSG00000075214
Gene Name olfactory receptor family 5 subfamily G member 25
Synonyms MOR175-2, Olfr1002, GA_x6K02T2Q125-47127746-47126790
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # IGL02591
Quality Score
Status
Chromosome 2
Chromosomal Location 85477707-85478663 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 85478487 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 59 (M59I)
Ref Sequence ENSEMBL: ENSMUSP00000150405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099920] [ENSMUST00000215548]
AlphaFold Q8VFK2
Predicted Effect probably damaging
Transcript: ENSMUST00000099920
AA Change: M59I

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000097504
Gene: ENSMUSG00000075214
AA Change: M59I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8.7e-50 PFAM
Pfam:7tm_1 41 290 2.5e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215548
AA Change: M59I

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921504E06Rik A T 2: 19,485,249 (GRCm39) F448I probably benign Het
Afg3l1 T C 8: 124,212,748 (GRCm39) F170L probably damaging Het
Aox1 A T 1: 58,398,158 (GRCm39) R1300* probably null Het
Cadps G A 14: 12,473,465 (GRCm38) R899C probably damaging Het
Ckap4 T C 10: 84,364,454 (GRCm39) D203G probably damaging Het
Dsg1c A G 18: 20,408,249 (GRCm39) N433D probably damaging Het
Eapp T C 12: 54,739,607 (GRCm39) N70S probably damaging Het
Eno3 A T 11: 70,552,853 (GRCm39) D378V probably damaging Het
Ep400 T A 5: 110,881,638 (GRCm39) probably benign Het
F13a1 T A 13: 37,082,031 (GRCm39) I558F probably damaging Het
Fermt1 A T 2: 132,776,786 (GRCm39) M234K possibly damaging Het
Fgfr1op2 A G 6: 146,490,344 (GRCm39) Q81R probably damaging Het
Gpm6a C T 8: 55,511,954 (GRCm39) A276V probably damaging Het
Hecw1 C A 13: 14,531,821 (GRCm39) probably benign Het
Ikbip G T 10: 90,932,154 (GRCm39) C266F probably damaging Het
Lpar2 C T 8: 70,276,700 (GRCm39) A163V probably benign Het
Med17 T A 9: 15,181,657 (GRCm39) H31L probably damaging Het
Otoa T C 7: 120,755,053 (GRCm39) F992L probably damaging Het
Ptprd T C 4: 75,900,287 (GRCm39) H864R probably damaging Het
Samd9l A C 6: 3,375,760 (GRCm39) C500W possibly damaging Het
Sarm1 A T 11: 78,378,178 (GRCm39) Y501N probably damaging Het
Selp A T 1: 163,957,702 (GRCm39) H277L probably damaging Het
Slc39a8 T G 3: 135,590,381 (GRCm39) L358R probably damaging Het
Spi1 T A 2: 90,927,295 (GRCm39) M1K probably null Het
Thsd1 A G 8: 22,748,743 (GRCm39) E477G probably damaging Het
Tlr1 C T 5: 65,084,059 (GRCm39) V173M probably damaging Het
Tmco2 C T 4: 120,962,987 (GRCm39) D171N probably damaging Het
Ugt2b1 A G 5: 87,065,563 (GRCm39) L492P probably damaging Het
Vmn2r70 A T 7: 85,214,153 (GRCm39) I333K probably damaging Het
Zfp598 C A 17: 24,896,478 (GRCm39) P185Q probably damaging Het
Zfp711 T A X: 111,542,391 (GRCm39) M474K probably benign Het
Zscan18 T C 7: 12,509,206 (GRCm39) probably benign Het
Other mutations in Or5g25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02873:Or5g25 APN 2 85,478,096 (GRCm39) missense possibly damaging 0.50
PIT4362001:Or5g25 UTSW 2 85,478,068 (GRCm39) missense probably damaging 1.00
R1241:Or5g25 UTSW 2 85,477,904 (GRCm39) missense probably damaging 1.00
R1261:Or5g25 UTSW 2 85,478,143 (GRCm39) missense probably damaging 1.00
R1666:Or5g25 UTSW 2 85,478,157 (GRCm39) nonsense probably null
R1902:Or5g25 UTSW 2 85,478,201 (GRCm39) missense possibly damaging 0.81
R1965:Or5g25 UTSW 2 85,478,090 (GRCm39) missense possibly damaging 0.94
R2096:Or5g25 UTSW 2 85,478,434 (GRCm39) missense probably benign 0.20
R4239:Or5g25 UTSW 2 85,478,647 (GRCm39) missense probably damaging 0.98
R4730:Or5g25 UTSW 2 85,478,336 (GRCm39) missense probably benign 0.39
R4948:Or5g25 UTSW 2 85,477,916 (GRCm39) missense probably benign 0.30
R5627:Or5g25 UTSW 2 85,477,991 (GRCm39) missense probably damaging 1.00
R5844:Or5g25 UTSW 2 85,478,239 (GRCm39) missense probably benign 0.36
R6809:Or5g25 UTSW 2 85,478,317 (GRCm39) missense probably damaging 1.00
R7399:Or5g25 UTSW 2 85,477,768 (GRCm39) missense possibly damaging 0.89
R7476:Or5g25 UTSW 2 85,478,512 (GRCm39) missense not run
R7805:Or5g25 UTSW 2 85,477,794 (GRCm39) nonsense probably null
R7960:Or5g25 UTSW 2 85,478,417 (GRCm39) missense possibly damaging 0.82
R8015:Or5g25 UTSW 2 85,478,136 (GRCm39) missense probably damaging 0.99
R8355:Or5g25 UTSW 2 85,478,485 (GRCm39) missense probably damaging 1.00
R8455:Or5g25 UTSW 2 85,478,485 (GRCm39) missense probably damaging 1.00
R8479:Or5g25 UTSW 2 85,478,447 (GRCm39) missense probably damaging 1.00
R8683:Or5g25 UTSW 2 85,478,410 (GRCm39) missense probably benign 0.35
R8699:Or5g25 UTSW 2 85,478,330 (GRCm39) missense possibly damaging 0.87
R8762:Or5g25 UTSW 2 85,478,034 (GRCm39) missense probably damaging 1.00
R8897:Or5g25 UTSW 2 85,478,187 (GRCm39) missense possibly damaging 0.92
R9280:Or5g25 UTSW 2 85,478,504 (GRCm39) nonsense probably null
R9674:Or5g25 UTSW 2 85,478,593 (GRCm39) missense possibly damaging 0.94
Posted On 2015-04-16