Incidental Mutation 'IGL02591:Lpar2'
ID 299747
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lpar2
Ensembl Gene ENSMUSG00000031861
Gene Name lysophosphatidic acid receptor 2
Synonyms LPA2, Edg4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02591
Quality Score
Status
Chromosome 8
Chromosomal Location 70275215-70283752 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 70276700 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 163 (A163V)
Ref Sequence ENSEMBL: ENSMUSP00000128261 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034325] [ENSMUST00000036074] [ENSMUST00000164890]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000034325
AA Change: A163V

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000034325
Gene: ENSMUSG00000031861
AA Change: A163V

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 40 307 8.1e-10 PFAM
Pfam:7tm_1 46 292 5.1e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000036074
SMART Domains Protein: ENSMUSP00000045676
Gene: ENSMUSG00000036246

DomainStartEndE-ValueType
PDB:3QWE|A 85 356 1e-149 PDB
low complexity region 358 367 N/A INTRINSIC
low complexity region 389 406 N/A INTRINSIC
low complexity region 419 431 N/A INTRINSIC
C1 491 536 1.75e-6 SMART
RhoGAP 561 753 1.06e-61 SMART
Blast:RhoGAP 824 971 1e-53 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144540
Predicted Effect probably benign
Transcript: ENSMUST00000164890
AA Change: A163V

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000128261
Gene: ENSMUSG00000031861
AA Change: A163V

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 40 307 8.1e-10 PFAM
Pfam:7tm_1 46 292 1.1e-32 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Animals homozyogous for a targeted mutation appear phenotypically normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921504E06Rik A T 2: 19,485,249 (GRCm39) F448I probably benign Het
Afg3l1 T C 8: 124,212,748 (GRCm39) F170L probably damaging Het
Aox1 A T 1: 58,398,158 (GRCm39) R1300* probably null Het
Cadps G A 14: 12,473,465 (GRCm38) R899C probably damaging Het
Ckap4 T C 10: 84,364,454 (GRCm39) D203G probably damaging Het
Dsg1c A G 18: 20,408,249 (GRCm39) N433D probably damaging Het
Eapp T C 12: 54,739,607 (GRCm39) N70S probably damaging Het
Eno3 A T 11: 70,552,853 (GRCm39) D378V probably damaging Het
Ep400 T A 5: 110,881,638 (GRCm39) probably benign Het
F13a1 T A 13: 37,082,031 (GRCm39) I558F probably damaging Het
Fermt1 A T 2: 132,776,786 (GRCm39) M234K possibly damaging Het
Fgfr1op2 A G 6: 146,490,344 (GRCm39) Q81R probably damaging Het
Gpm6a C T 8: 55,511,954 (GRCm39) A276V probably damaging Het
Hecw1 C A 13: 14,531,821 (GRCm39) probably benign Het
Ikbip G T 10: 90,932,154 (GRCm39) C266F probably damaging Het
Med17 T A 9: 15,181,657 (GRCm39) H31L probably damaging Het
Or5g25 C A 2: 85,478,487 (GRCm39) M59I probably damaging Het
Otoa T C 7: 120,755,053 (GRCm39) F992L probably damaging Het
Ptprd T C 4: 75,900,287 (GRCm39) H864R probably damaging Het
Samd9l A C 6: 3,375,760 (GRCm39) C500W possibly damaging Het
Sarm1 A T 11: 78,378,178 (GRCm39) Y501N probably damaging Het
Selp A T 1: 163,957,702 (GRCm39) H277L probably damaging Het
Slc39a8 T G 3: 135,590,381 (GRCm39) L358R probably damaging Het
Spi1 T A 2: 90,927,295 (GRCm39) M1K probably null Het
Thsd1 A G 8: 22,748,743 (GRCm39) E477G probably damaging Het
Tlr1 C T 5: 65,084,059 (GRCm39) V173M probably damaging Het
Tmco2 C T 4: 120,962,987 (GRCm39) D171N probably damaging Het
Ugt2b1 A G 5: 87,065,563 (GRCm39) L492P probably damaging Het
Vmn2r70 A T 7: 85,214,153 (GRCm39) I333K probably damaging Het
Zfp598 C A 17: 24,896,478 (GRCm39) P185Q probably damaging Het
Zfp711 T A X: 111,542,391 (GRCm39) M474K probably benign Het
Zscan18 T C 7: 12,509,206 (GRCm39) probably benign Het
Other mutations in Lpar2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00964:Lpar2 APN 8 70,279,162 (GRCm39) missense probably benign
R0403:Lpar2 UTSW 8 70,276,802 (GRCm39) missense probably damaging 0.97
R0715:Lpar2 UTSW 8 70,276,823 (GRCm39) missense probably damaging 1.00
R1427:Lpar2 UTSW 8 70,276,700 (GRCm39) missense possibly damaging 0.48
R5735:Lpar2 UTSW 8 70,276,385 (GRCm39) missense probably damaging 0.98
R7084:Lpar2 UTSW 8 70,276,256 (GRCm39) missense probably damaging 1.00
R7434:Lpar2 UTSW 8 70,279,165 (GRCm39) missense probably benign
Posted On 2015-04-16