Incidental Mutation 'IGL02592:Zfp947'
ID299758
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp947
Ensembl Gene ENSMUSG00000063383
Gene Namezinc finger protein 947
SynonymsGm4769
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock #IGL02592
Quality Score
Status
Chromosome17
Chromosomal Location22144359-22166190 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 22146252 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Leucine at position 147 (Q147L)
Ref Sequence ENSEMBL: ENSMUSP00000079137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080249]
Predicted Effect possibly damaging
Transcript: ENSMUST00000080249
AA Change: Q147L

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000079137
Gene: ENSMUSG00000063383
AA Change: Q147L

DomainStartEndE-ValueType
KRAB 13 73 9.26e-19 SMART
ZnF_C2H2 183 205 7.05e-1 SMART
ZnF_C2H2 211 233 1.5e-4 SMART
ZnF_C2H2 239 261 7.67e-2 SMART
ZnF_C2H2 267 289 2.79e-4 SMART
ZnF_C2H2 295 317 5.59e-4 SMART
ZnF_C2H2 323 345 4.24e-4 SMART
ZnF_C2H2 351 373 3.21e-4 SMART
ZnF_C2H2 379 401 5.99e-4 SMART
ZnF_C2H2 407 429 8.02e-5 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cadps G A 14: 12,473,465 R899C probably damaging Het
Cass4 T C 2: 172,416,328 L82P probably benign Het
Cd53 C A 3: 106,763,285 C144F probably damaging Het
Fancc G A 13: 63,360,197 R175W probably damaging Het
Gm10717 A T 9: 3,026,287 Y195F probably damaging Het
Gpr149 T C 3: 62,603,810 D256G possibly damaging Het
Kdm5b T A 1: 134,624,853 M1189K probably damaging Het
Lvrn T A 18: 46,850,591 C134S probably damaging Het
Mroh8 A T 2: 157,216,969 Y926N probably damaging Het
Nfxl1 A G 5: 72,514,229 S896P probably benign Het
Orc4 A T 2: 48,933,078 probably null Het
Pcsk6 T A 7: 65,969,028 H447Q probably damaging Het
Rfx6 C A 10: 51,716,023 Q121K probably damaging Het
Rnase6 T C 14: 51,130,525 Y125H probably benign Het
Sbno1 A T 5: 124,400,809 Y494N probably damaging Het
Sppl3 G A 5: 115,095,911 V347M probably damaging Het
Tlr12 G A 4: 128,617,686 T257M probably benign Het
Tmem132e A T 11: 82,434,636 D154V probably damaging Het
Zfp345 A G 2: 150,473,309 Y103H probably benign Het
Other mutations in Zfp947
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02092:Zfp947 APN 17 22147496 missense probably damaging 1.00
R0070:Zfp947 UTSW 17 22146184 missense probably benign 0.00
R1519:Zfp947 UTSW 17 22146292 missense probably benign 0.02
R1521:Zfp947 UTSW 17 22145832 missense probably benign 0.00
R1639:Zfp947 UTSW 17 22146093 missense probably benign
R1721:Zfp947 UTSW 17 22146203 missense probably benign
R1801:Zfp947 UTSW 17 22146462 missense probably benign
R2264:Zfp947 UTSW 17 22145938 missense probably benign
R3943:Zfp947 UTSW 17 22145820 missense probably damaging 1.00
R4561:Zfp947 UTSW 17 22146143 nonsense probably null
R4562:Zfp947 UTSW 17 22146143 nonsense probably null
R4943:Zfp947 UTSW 17 22145832 missense probably benign
R5688:Zfp947 UTSW 17 22146085 missense probably benign 0.00
R6037:Zfp947 UTSW 17 22147434 missense probably damaging 0.99
R6037:Zfp947 UTSW 17 22147434 missense probably damaging 0.99
R6414:Zfp947 UTSW 17 22146414 missense probably damaging 0.98
R6786:Zfp947 UTSW 17 22145769 missense probably benign 0.01
R6993:Zfp947 UTSW 17 22145980 missense probably benign 0.11
R7556:Zfp947 UTSW 17 22145616 missense probably benign
Posted On2015-04-16