Incidental Mutation 'IGL02593:Gm17677'
ID299790
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm17677
Ensembl Gene ENSMUSG00000091174
Gene Namepredicted gene, 17677
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL02593
Quality Score
Status
Chromosome9
Chromosomal Location35741049-35742252 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 35742142 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 81 (C81S)
Ref Sequence ENSEMBL: ENSMUSP00000132657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166746]
Predicted Effect possibly damaging
Transcript: ENSMUST00000166746
AA Change: C81S

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000132657
Gene: ENSMUSG00000091174
AA Change: C81S

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahsg G T 16: 22,892,328 probably null Het
Bbs4 C T 9: 59,328,597 D232N probably damaging Het
Cdh23 A T 10: 60,465,995 probably benign Het
Cntn5 T C 9: 9,833,499 N554S probably damaging Het
Fn1 T C 1: 71,602,432 I1652V probably benign Het
Gm364 G A X: 57,421,960 D245N probably benign Het
Golga4 T C 9: 118,555,566 probably benign Het
Idh3a T A 9: 54,596,193 probably benign Het
Jph2 T C 2: 163,397,246 Y94C probably damaging Het
Lnx2 A G 5: 147,033,015 S238P possibly damaging Het
Loxhd1 A G 18: 77,410,539 I56V possibly damaging Het
Myo9b A C 8: 71,290,773 E159D probably damaging Het
Nkiras1 A G 14: 18,278,475 N63S possibly damaging Het
Nnmt A G 9: 48,604,803 probably null Het
Olfr535 G A 7: 140,493,331 R231H probably benign Het
P2ry10 T C X: 107,102,696 I79T possibly damaging Het
Padi2 A G 4: 140,949,842 H647R probably damaging Het
Ptchd4 A G 17: 42,317,146 D166G probably benign Het
Scml2 T C X: 161,187,309 V125A probably benign Het
Senp2 A G 16: 22,044,271 D556G probably damaging Het
Serpina3a G T 12: 104,118,432 V29L probably benign Het
Sgcz A T 8: 37,523,278 I307N probably damaging Het
Slc25a13 C T 6: 6,042,265 V638I probably benign Het
Snx7 G A 3: 117,839,960 L84F probably damaging Het
Ticrr A G 7: 79,695,466 D1693G probably damaging Het
Vmn2r7 C T 3: 64,693,022 C485Y probably damaging Het
Vmn2r-ps129 C T 17: 22,992,796 noncoding transcript Het
Zfyve9 A G 4: 108,682,223 V951A possibly damaging Het
Other mutations in Gm17677
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02612:Gm17677 APN 9 35742164 missense possibly damaging 0.92
IGL02648:Gm17677 APN 9 35741109 missense probably benign 0.14
IGL02698:Gm17677 APN 9 35741120 splice site probably benign
R4240:Gm17677 UTSW 9 35742153 nonsense probably null
R4983:Gm17677 UTSW 9 35742169 missense probably benign 0.12
R5161:Gm17677 UTSW 9 35741588 nonsense probably null
R5545:Gm17677 UTSW 9 35741644 missense probably benign 0.10
R5980:Gm17677 UTSW 9 35741615 missense probably damaging 0.99
R6131:Gm17677 UTSW 9 35741544 nonsense probably null
R6147:Gm17677 UTSW 9 35742110 missense possibly damaging 0.94
R6147:Gm17677 UTSW 9 35742232 missense possibly damaging 0.66
X0066:Gm17677 UTSW 9 35742170 missense possibly damaging 0.90
Posted On2015-04-16