Incidental Mutation 'IGL02593:Gm17677'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm17677
Ensembl Gene ENSMUSG00000091174
Gene Namepredicted gene, 17677
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL02593
Quality Score
Chromosomal Location35741049-35742252 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 35742142 bp
Amino Acid Change Cysteine to Serine at position 81 (C81S)
Ref Sequence ENSEMBL: ENSMUSP00000132657 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000166746]
Predicted Effect possibly damaging
Transcript: ENSMUST00000166746
AA Change: C81S

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000132657
Gene: ENSMUSG00000091174
AA Change: C81S

signal peptide 1 22 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahsg G T 16: 22,892,328 probably null Het
Bbs4 C T 9: 59,328,597 D232N probably damaging Het
Cdh23 A T 10: 60,465,995 probably benign Het
Cntn5 T C 9: 9,833,499 N554S probably damaging Het
Fn1 T C 1: 71,602,432 I1652V probably benign Het
Gm364 G A X: 57,421,960 D245N probably benign Het
Golga4 T C 9: 118,555,566 probably benign Het
Idh3a T A 9: 54,596,193 probably benign Het
Jph2 T C 2: 163,397,246 Y94C probably damaging Het
Lnx2 A G 5: 147,033,015 S238P possibly damaging Het
Loxhd1 A G 18: 77,410,539 I56V possibly damaging Het
Myo9b A C 8: 71,290,773 E159D probably damaging Het
Nkiras1 A G 14: 18,278,475 N63S possibly damaging Het
Nnmt A G 9: 48,604,803 probably null Het
Olfr535 G A 7: 140,493,331 R231H probably benign Het
P2ry10 T C X: 107,102,696 I79T possibly damaging Het
Padi2 A G 4: 140,949,842 H647R probably damaging Het
Ptchd4 A G 17: 42,317,146 D166G probably benign Het
Scml2 T C X: 161,187,309 V125A probably benign Het
Senp2 A G 16: 22,044,271 D556G probably damaging Het
Serpina3a G T 12: 104,118,432 V29L probably benign Het
Sgcz A T 8: 37,523,278 I307N probably damaging Het
Slc25a13 C T 6: 6,042,265 V638I probably benign Het
Snx7 G A 3: 117,839,960 L84F probably damaging Het
Ticrr A G 7: 79,695,466 D1693G probably damaging Het
Vmn2r7 C T 3: 64,693,022 C485Y probably damaging Het
Vmn2r-ps129 C T 17: 22,992,796 noncoding transcript Het
Zfyve9 A G 4: 108,682,223 V951A possibly damaging Het
Other mutations in Gm17677
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02612:Gm17677 APN 9 35742164 missense possibly damaging 0.92
IGL02648:Gm17677 APN 9 35741109 missense probably benign 0.14
IGL02698:Gm17677 APN 9 35741120 splice site probably benign
R4240:Gm17677 UTSW 9 35742153 nonsense probably null
R4983:Gm17677 UTSW 9 35742169 missense probably benign 0.12
R5161:Gm17677 UTSW 9 35741588 nonsense probably null
R5545:Gm17677 UTSW 9 35741644 missense probably benign 0.10
R5980:Gm17677 UTSW 9 35741615 missense probably damaging 0.99
R6131:Gm17677 UTSW 9 35741544 nonsense probably null
R6147:Gm17677 UTSW 9 35742110 missense possibly damaging 0.94
R6147:Gm17677 UTSW 9 35742232 missense possibly damaging 0.66
X0066:Gm17677 UTSW 9 35742170 missense possibly damaging 0.90
Posted On2015-04-16