Incidental Mutation 'IGL02596:Clptm1l'
ID 299876
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Clptm1l
Ensembl Gene ENSMUSG00000021610
Gene Name CLPTM1-like
Synonyms C130052I12Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02596
Quality Score
Chromosome 13
Chromosomal Location 73604006-73620605 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 73613666 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 330 (R330C)
Ref Sequence ENSEMBL: ENSMUSP00000022102 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022102]
AlphaFold Q8BXA5
Predicted Effect probably benign
Transcript: ENSMUST00000022102
AA Change: R330C

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000022102
Gene: ENSMUSG00000021610
AA Change: R330C

Pfam:CLPTM1 10 423 3.2e-134 PFAM
transmembrane domain 428 450 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221130
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221417
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222343
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310002L09Rik T G 4: 73,950,667 (GRCm38) Q11H possibly damaging Het
Armcx5 T A X: 135,746,519 (GRCm38) I448K probably damaging Het
Atp4b T A 8: 13,393,471 (GRCm38) Y69F possibly damaging Het
Ccdc7b T A 8: 129,072,478 (GRCm38) V12E probably benign Het
Cdc5l C A 17: 45,424,604 (GRCm38) probably benign Het
Cpq C T 15: 33,213,014 (GRCm38) R60W probably damaging Het
Cpvl T C 6: 53,932,010 (GRCm38) Y256C probably damaging Het
Cryzl2 A T 1: 157,464,969 (GRCm38) D107V probably damaging Het
Cyp2e1 G A 7: 140,770,118 (GRCm38) V239M probably damaging Het
Cyp2j7 T A 4: 96,215,422 (GRCm38) D292V possibly damaging Het
Dcaf1 A G 9: 106,863,021 (GRCm38) Y1202C probably damaging Het
Dnah3 T C 7: 119,938,914 (GRCm38) N3616S probably benign Het
Enam A G 5: 88,503,026 (GRCm38) D723G probably benign Het
Eps8l1 G A 7: 4,470,872 (GRCm38) R226H probably damaging Het
Erich2 A G 2: 70,512,803 (GRCm38) probably benign Het
Esyt3 A C 9: 99,328,015 (GRCm38) L271V probably benign Het
Fer1l4 T C 2: 156,039,132 (GRCm38) N838S probably benign Het
Gad1 T C 2: 70,594,684 (GRCm38) Y441H probably damaging Het
Gja1 G T 10: 56,388,252 (GRCm38) V236F possibly damaging Het
Gpr156 T C 16: 37,978,724 (GRCm38) I100T probably benign Het
Hace1 A G 10: 45,700,640 (GRCm38) T803A possibly damaging Het
Jagn1 G A 6: 113,447,601 (GRCm38) V145I probably benign Het
Kdm4b C A 17: 56,399,706 (GRCm38) T899K probably benign Het
Klk1b8 G A 7: 43,952,763 (GRCm38) V40M probably damaging Het
Lyst G A 13: 13,660,956 (GRCm38) C1741Y probably benign Het
Mast1 G T 8: 84,917,771 (GRCm38) A843E probably benign Het
Mbd1 T A 18: 74,276,797 (GRCm38) probably benign Het
Mdga1 A G 17: 29,832,405 (GRCm38) probably benign Het
Mlh3 A G 12: 85,240,958 (GRCm38) probably null Het
Or10ag53 C A 2: 87,252,129 (GRCm38) T64K probably damaging Het
Or5b109 A T 19: 13,234,399 (GRCm38) I50F probably damaging Het
Pwp1 A G 10: 85,872,018 (GRCm38) probably null Het
Rbm12 C T 2: 156,095,560 (GRCm38) probably benign Het
Slc12a7 T A 13: 73,785,123 (GRCm38) V100E probably benign Het
Spata31e2 T A 1: 26,684,002 (GRCm38) H699L probably benign Het
Srrm1 G A 4: 135,325,104 (GRCm38) P658L unknown Het
Tgfb1i1 T A 7: 128,248,896 (GRCm38) M1K probably null Het
Tubgcp6 T A 15: 89,100,914 (GRCm38) E1657V probably damaging Het
Zfp770 A G 2: 114,195,827 (GRCm38) V587A probably benign Het
Zxdc A G 6: 90,373,709 (GRCm38) probably null Het
Other mutations in Clptm1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01672:Clptm1l APN 13 73,607,873 (GRCm38) splice site probably null
IGL01963:Clptm1l APN 13 73,617,569 (GRCm38) splice site probably benign
IGL02169:Clptm1l APN 13 73,611,663 (GRCm38) missense probably damaging 0.96
IGL02554:Clptm1l APN 13 73,607,760 (GRCm38) missense probably benign 0.07
IGL02720:Clptm1l APN 13 73,614,602 (GRCm38) splice site probably benign
IGL03100:Clptm1l APN 13 73,612,390 (GRCm38) splice site probably benign
P0023:Clptm1l UTSW 13 73,604,952 (GRCm38) missense possibly damaging 0.67
R0308:Clptm1l UTSW 13 73,611,667 (GRCm38) missense possibly damaging 0.67
R0725:Clptm1l UTSW 13 73,606,343 (GRCm38) missense probably benign
R1572:Clptm1l UTSW 13 73,607,747 (GRCm38) missense probably benign
R1589:Clptm1l UTSW 13 73,614,673 (GRCm38) critical splice donor site probably null
R2062:Clptm1l UTSW 13 73,607,723 (GRCm38) nonsense probably null
R2064:Clptm1l UTSW 13 73,607,723 (GRCm38) nonsense probably null
R2065:Clptm1l UTSW 13 73,607,723 (GRCm38) nonsense probably null
R2067:Clptm1l UTSW 13 73,607,723 (GRCm38) nonsense probably null
R2068:Clptm1l UTSW 13 73,607,723 (GRCm38) nonsense probably null
R3003:Clptm1l UTSW 13 73,617,756 (GRCm38) missense possibly damaging 0.51
R3712:Clptm1l UTSW 13 73,616,038 (GRCm38) missense probably benign 0.21
R3808:Clptm1l UTSW 13 73,612,454 (GRCm38) missense probably benign 0.13
R3966:Clptm1l UTSW 13 73,615,972 (GRCm38) missense probably damaging 1.00
R4615:Clptm1l UTSW 13 73,607,738 (GRCm38) nonsense probably null
R4801:Clptm1l UTSW 13 73,607,862 (GRCm38) missense possibly damaging 0.81
R4802:Clptm1l UTSW 13 73,607,862 (GRCm38) missense possibly damaging 0.81
R4957:Clptm1l UTSW 13 73,612,428 (GRCm38) missense probably damaging 1.00
R4957:Clptm1l UTSW 13 73,611,196 (GRCm38) missense possibly damaging 0.52
R5864:Clptm1l UTSW 13 73,606,284 (GRCm38) missense probably damaging 0.99
R6502:Clptm1l UTSW 13 73,617,765 (GRCm38) critical splice donor site probably null
R6701:Clptm1l UTSW 13 73,608,906 (GRCm38) missense probably benign 0.00
R6720:Clptm1l UTSW 13 73,618,516 (GRCm38) missense probably damaging 1.00
R7782:Clptm1l UTSW 13 73,604,320 (GRCm38) missense probably damaging 1.00
R8292:Clptm1l UTSW 13 73,617,735 (GRCm38) missense probably damaging 0.96
R8329:Clptm1l UTSW 13 73,612,428 (GRCm38) missense probably damaging 1.00
R9224:Clptm1l UTSW 13 73,604,225 (GRCm38) start gained probably benign
R9528:Clptm1l UTSW 13 73,612,431 (GRCm38) missense possibly damaging 0.76
Posted On 2015-04-16