Incidental Mutation 'R0359:Ces1g'
ID 30001
Institutional Source Beutler Lab
Gene Symbol Ces1g
Ensembl Gene ENSMUSG00000057074
Gene Name carboxylesterase 1G
Synonyms Ses-1, Ces-1, Ces1
MMRRC Submission 038565-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R0359 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 94028997-94063837 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 94055163 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000037555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044602]
AlphaFold Q8VCC2
Predicted Effect probably benign
Transcript: ENSMUST00000044602
SMART Domains Protein: ENSMUSP00000037555
Gene: ENSMUSG00000057074

DomainStartEndE-ValueType
Pfam:COesterase 1 545 3.6e-168 PFAM
Pfam:Abhydrolase_3 136 295 5.7e-11 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.2%
  • 10x: 96.1%
  • 20x: 92.3%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik T A 5: 144,982,181 (GRCm39) Y255* probably null Het
2310003L06Rik A T 5: 88,112,455 (GRCm39) probably benign Het
Abcb5 A G 12: 118,904,067 (GRCm39) S213P probably damaging Het
Agpat1 A G 17: 34,829,551 (GRCm39) I42V probably benign Het
Apoh A T 11: 108,288,199 (GRCm39) I106F probably damaging Het
BB014433 G T 8: 15,092,540 (GRCm39) C104* probably null Het
Bsn C T 9: 107,989,045 (GRCm39) G2236S possibly damaging Het
Casp9 A G 4: 141,521,221 (GRCm39) E19G probably damaging Het
Cfap65 T A 1: 74,959,760 (GRCm39) M797L probably benign Het
Col14a1 A G 15: 55,271,264 (GRCm39) probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Col27a1 G T 4: 63,232,964 (GRCm39) probably null Het
Col6a4 T A 9: 105,874,345 (GRCm39) H2214L probably benign Het
Ctu2 T G 8: 123,204,932 (GRCm39) S72R probably damaging Het
Cyp24a1 T A 2: 170,333,619 (GRCm39) M245L possibly damaging Het
Dgkb T A 12: 38,266,030 (GRCm39) V503E probably benign Het
Diaph3 T C 14: 87,206,938 (GRCm39) R501G probably benign Het
Dip2b A G 15: 100,109,874 (GRCm39) D1453G probably damaging Het
Dnah2 G A 11: 69,420,357 (GRCm39) T119M probably benign Het
F5 T G 1: 164,007,018 (GRCm39) V274G probably damaging Het
Farp1 A T 14: 121,492,808 (GRCm39) probably benign Het
Fcsk T C 8: 111,619,891 (GRCm39) probably null Het
Foxf1 T C 8: 121,811,742 (GRCm39) V202A possibly damaging Het
Fras1 G A 5: 96,910,449 (GRCm39) V3293I probably damaging Het
Furin C T 7: 80,041,032 (GRCm39) G602D probably damaging Het
Gclm T C 3: 122,049,269 (GRCm39) probably benign Het
Gemin4 G A 11: 76,102,988 (GRCm39) T591M probably benign Het
Glrx3 T C 7: 137,055,214 (GRCm39) S119P possibly damaging Het
Gm16485 G T 9: 8,972,437 (GRCm39) probably benign Het
Helq T C 5: 100,938,066 (GRCm39) N460S probably benign Het
Hs6st1 G A 1: 36,108,266 (GRCm39) probably null Het
Kpna2 A G 11: 106,882,148 (GRCm39) L226S probably damaging Het
Myom3 G A 4: 135,505,454 (GRCm39) V448M probably damaging Het
Nalcn A G 14: 123,536,580 (GRCm39) S1224P probably damaging Het
Or52n2 A T 7: 104,542,521 (GRCm39) F105I probably damaging Het
Or56b1b C T 7: 108,164,721 (GRCm39) D94N probably benign Het
Or7a38 A G 10: 78,753,177 (GRCm39) T168A probably benign Het
Plag1 C T 4: 3,904,546 (GRCm39) C215Y probably damaging Het
Plekha5 G A 6: 140,537,473 (GRCm39) R646K possibly damaging Het
Pot1a G A 6: 25,771,679 (GRCm39) probably benign Het
Ppfia1 T C 7: 144,038,929 (GRCm39) D494G probably damaging Het
Ppp1r1a T A 15: 103,441,915 (GRCm39) D51V probably damaging Het
Ptprz1 T A 6: 22,973,175 (GRCm39) probably benign Het
Rad51ap1 A T 6: 126,911,704 (GRCm39) V61D probably damaging Het
Reln G A 5: 22,253,798 (GRCm39) L605F probably damaging Het
Riok3 T C 18: 12,282,006 (GRCm39) I325T probably damaging Het
Sclt1 A T 3: 41,616,005 (GRCm39) probably null Het
Slc25a39 A G 11: 102,297,395 (GRCm39) V24A possibly damaging Het
Slc9a3 T G 13: 74,305,726 (GRCm39) S248A probably damaging Het
Slco6d1 T A 1: 98,394,422 (GRCm39) C369S probably benign Het
Spen T C 4: 141,244,181 (GRCm39) S285G unknown Het
Stxbp5l A G 16: 37,036,440 (GRCm39) probably benign Het
Thsd7a G A 6: 12,352,030 (GRCm39) P1055L probably damaging Het
Tmed3 C T 9: 89,581,842 (GRCm39) S207N possibly damaging Het
Trerf1 G T 17: 47,652,062 (GRCm39) noncoding transcript Het
Triml1 A T 8: 43,583,542 (GRCm39) V353E probably damaging Het
Ttn G A 2: 76,549,401 (GRCm39) R31759C probably damaging Het
Ugt2b37 T C 5: 87,398,443 (GRCm39) Q331R probably benign Het
Urb1 A G 16: 90,588,048 (GRCm39) I420T probably damaging Het
Vmn1r68 A T 7: 10,261,201 (GRCm39) L299Q probably damaging Het
Vmn1r81 T A 7: 11,993,877 (GRCm39) T244S probably damaging Het
Vps13a A G 19: 16,618,941 (GRCm39) F2875S probably damaging Het
Wscd1 A G 11: 71,657,692 (GRCm39) M166V probably damaging Het
Zfp296 T C 7: 19,313,864 (GRCm39) Y240H possibly damaging Het
Zfp462 A G 4: 55,013,689 (GRCm39) H737R probably damaging Het
Other mutations in Ces1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00841:Ces1g APN 8 94,029,615 (GRCm39) missense possibly damaging 0.61
IGL00971:Ces1g APN 8 94,029,660 (GRCm39) missense probably damaging 1.00
IGL01583:Ces1g APN 8 94,033,587 (GRCm39) missense probably damaging 1.00
IGL02993:Ces1g APN 8 94,043,707 (GRCm39) missense probably benign 0.00
IGL03386:Ces1g APN 8 94,052,440 (GRCm39) missense probably benign 0.00
R0373:Ces1g UTSW 8 94,057,821 (GRCm39) missense probably benign 0.06
R0499:Ces1g UTSW 8 94,060,317 (GRCm39) missense probably benign 0.01
R0689:Ces1g UTSW 8 94,055,035 (GRCm39) missense probably damaging 1.00
R1756:Ces1g UTSW 8 94,033,582 (GRCm39) missense probably benign 0.03
R3052:Ces1g UTSW 8 94,061,676 (GRCm39) missense possibly damaging 0.50
R3150:Ces1g UTSW 8 94,052,444 (GRCm39) missense probably benign 0.45
R3899:Ces1g UTSW 8 94,029,678 (GRCm39) missense probably damaging 1.00
R3966:Ces1g UTSW 8 94,055,139 (GRCm39) missense possibly damaging 0.50
R4134:Ces1g UTSW 8 94,046,500 (GRCm39) missense probably benign 0.00
R4198:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.11
R4332:Ces1g UTSW 8 94,046,446 (GRCm39) missense probably benign 0.01
R4719:Ces1g UTSW 8 94,043,718 (GRCm39) missense possibly damaging 0.59
R4841:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4842:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4843:Ces1g UTSW 8 94,057,893 (GRCm39) missense probably damaging 1.00
R5344:Ces1g UTSW 8 94,063,821 (GRCm39) start gained probably benign
R5405:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.29
R5425:Ces1g UTSW 8 94,052,428 (GRCm39) missense probably benign 0.20
R5884:Ces1g UTSW 8 94,033,558 (GRCm39) missense probably benign 0.24
R6022:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R6183:Ces1g UTSW 8 94,057,867 (GRCm39) missense possibly damaging 0.48
R6197:Ces1g UTSW 8 94,063,764 (GRCm39) missense probably benign 0.01
R6307:Ces1g UTSW 8 94,057,820 (GRCm39) missense possibly damaging 0.60
R6688:Ces1g UTSW 8 94,033,600 (GRCm39) missense possibly damaging 0.92
R6863:Ces1g UTSW 8 94,043,647 (GRCm39) missense possibly damaging 0.92
R7097:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7122:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7180:Ces1g UTSW 8 94,029,576 (GRCm39) missense probably benign 0.04
R7202:Ces1g UTSW 8 94,029,595 (GRCm39) missense probably benign 0.01
R7361:Ces1g UTSW 8 94,060,307 (GRCm39) missense not run
R7537:Ces1g UTSW 8 94,046,455 (GRCm39) missense probably benign 0.01
R7621:Ces1g UTSW 8 94,055,094 (GRCm39) missense probably damaging 1.00
R8200:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R8895:Ces1g UTSW 8 94,046,512 (GRCm39) missense possibly damaging 0.83
R9248:Ces1g UTSW 8 94,060,319 (GRCm39) missense possibly damaging 0.62
R9290:Ces1g UTSW 8 94,029,545 (GRCm39) missense probably benign 0.07
R9324:Ces1g UTSW 8 94,055,118 (GRCm39) missense probably damaging 1.00
R9361:Ces1g UTSW 8 94,061,646 (GRCm39) critical splice donor site probably null
R9565:Ces1g UTSW 8 94,061,792 (GRCm39) missense probably benign 0.06
R9615:Ces1g UTSW 8 94,061,807 (GRCm39) missense probably damaging 1.00
Z1176:Ces1g UTSW 8 94,052,439 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AGGCATCCACCATCTGATGCTGAG -3'
(R):5'- TTGGCCTGTGGTATACAGCAAGGG -3'

Sequencing Primer
(F):5'- TGTTGGCAGCTACATCCAGAC -3'
(R):5'- GGGCTAAGTGTAACCAAAGATTTC -3'
Posted On 2013-04-24